But new research at the Weizmann Institute of Science shows that odors can be rated on a scale of pleasantness, and this turns out to be an organizing principle for the way we experience smell.
The findings, which appeared today in Nature Neuroscience, reveal a correlation between the response of certain nerves to particular scents and the pleasantness of those scents. Based on this correlation, the researchers could tell by measuring the nerve responses whether a subject found a smell pleasant or unpleasant.
Our various sensory organs have evolved patterns of organization that reflect the type of input they receive. Thus the receptors in the retina, in the back of the eye, are arranged spatially for efficiently mapping out visual coordinates. The structure of the inner ear, on the other hand, is set up according to a tonal scale. But the organizational principle for our sense of smell has remained a mystery: Scientists have not even been sure if there is a scale that determines the organization of our smell organ, much less how the arrangement of smell receptors on the membranes in our nasal passages might reflect such a scale.
A team headed by Prof. Noam Sobel of the Weizmann Institute’s Department of Neurobiology set out to search for the principle of organization for smell. Hints that the answer could be tied to pleasantness had been seen in research labs around the world, including that of Prof. Sobel, who had previously found a connection between the chemical structure of an odor molecule and its place on a pleasantness scale. Prof. Sobel and his team thought that smell receptors in the nose—of which there are some 400 subtypes—could be arranged on the nasal membrane according to this scale. This hypothesis goes against the conventional view, which claims that the various smell receptors are mixed—distributed evenly, but randomly, around the membrane.
In the experiment, the researchers inserted electrodes into the nasal passages of volunteers and measured the nerves’ responses to different smells in various sites. Each measurement actually captured the response of thousands of smell receptors, as these are densely packed on the membrane. The scientists found that the strength of the nerve signal varies from place to place on the membrane. It appeared that the receptors are not evenly distributed, but rather are grouped into distinct sites, each engaging most strongly with a particular type of scent.
Further investigation showed that the intensity of a reaction was linked to the odor’s place on the pleasantness scale. A site where the nerves reacted strongly to a certain agreeable scent also showed strong reactions to other pleasing smells and vice versa: The nerves in an area with a high response to an unpleasant odor reacted similarly to other disagreeable smells. The implication is that a pleasantness scale is, indeed, an organizing principle for our smell organ.
But does our sense of smell really work according to this simple principle? Natural odors are composed of a large number of molecules—roses, for instance, release 172 different odor molecules. Nonetheless, says Prof. Sobel, the most dominant of those determine which sites on the membrane will react the most strongly, while the other substances make secondary contributions to the scent.
“We uncovered a clear correlation between the pattern of nerve reaction to various smells and the pleasantness of those smells. As in sight and hearing, the receptors for our sense of smell are spatially organized in a way that reflects the nature of the sensory experience,” says Prof. Sobel. In addition, the findings confirm the idea that our experience of smells as nice or nasty is hardwired into our physiology, and not purely the result of individual preference. Prof. Sobel doesn’t discount the idea that individuals may experience smells differently, and theorizes that cultural context and personal experience may cause a certain amount of reorganization in smell perception over a person’s lifetime.
This research was carried out by Drs. Hadas Lapid, Sagit Shushan, and Anton Plotkin in the group of Prof. Noam Sobel; Dr. Elad Schneidman of the Weizmann Institute’s Department of Neurobiology; Dr. Yehudah Roth of Wolfson Hospital in Holon; Prof. Hillary Voet of the Hebrew University of Jerusalem; and Prof. Thomas Hummel of Dresden University, Germany.
Prof. Noam Sobel’s research is supported by Regina Wachter, NY; the estate of Lore Lennon; the James S. McDonnell Foundation 21st Century Science Scholar in Understanding Human Cognition Program; the Minerva Foundation; and the European Research Council.
The Weizmann Institute of Science in Rehovot, Israel, is one of the world’s top-ranking multidisciplinary research institutions. Noted for its wide-ranging exploration of the natural and exact sciences, the Institute is home to 2,700 scientists, students, technicians, and supporting staff. Institute research efforts include the search for new ways of fighting disease and hunger, examining leading questions in mathematics and computer science, probing the physics of matter and the universe, creating novel materials, and developing new strategies for protecting the environment.
Jennifer Manning | Newswise Science News
Toward a 'smart' patch that automatically delivers insulin when needed
18.01.2017 | American Chemical Society
127 at one blow...
18.01.2017 | Stiftung Zoologisches Forschungsmuseum Alexander Koenig, Leibniz-Institut für Biodiversität der Tiere
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).
Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...
10.01.2017 | Event News
09.01.2017 | Event News
05.01.2017 | Event News
18.01.2017 | Power and Electrical Engineering
18.01.2017 | Materials Sciences
18.01.2017 | Life Sciences