The type of therapy a cancer patient receives, largely depends on the trained eye of a pathologist.
Investigating diseased organs and tissues under the microscope is one of their tasks. However, human judgment is, by its very nature, subject to a certain degree of variation. To enhance the quality of diagnosis, scientists at Vetmeduni Vienna, the Medical University of Vienna and the Ludwig Boltzmann Institute for Cancer Research have developed a software that specifically identifies cell structures and proteins in order to provide reliable diagnoses. The scientists published their data in the journal Plos One.
Together with the company Tissuegnostics, the pathologist Lukas Kenner and his colleagues have developed a software that is able to identify cancer cells in tissue sections and demonstrate the presence of specific biomarkers on cells. The overall information provides a precise picture of the disease and leads to the most suitable treatment.
According to the results of the study, "Two independent pathologists concur with each other only in regard of every third diagnosis."
"The recently developed software offers, for the first time, the option of eliminating the so-called inter-observer-variability, which is the systematic variability of judgement among different observers," chief investigators Lukas Kenner and Helmut Dolznig explain.
Software identifies the severity of cancer
The scientists investigated and analyzed 30 liver cell carcinomas, and clearly assigned these to the categories "negative" or "highly positive" with the help of the software. For this purpose the scientists analyzed the expression of specific proteins like Stat5 and JunB, which play an important role in the emergence of cancer. The software utilizes specific algorithms and highly sensitive digital photography, and is able to more clearly depict the matrix of cells and the cell nucleus than the view achieved by the human eye using a microscope.
Changes in cancer cells can be specified more exactly
"We have been using the software in research for several years. The technology will obviously not replace pathologists, but is a supplementary technology that markedly enhances the reliability of the diagnosis," Kenner states. Kenner also believes that the new technology will help to specify the categories in which in cancer cells are classified with greater accuracy in the future.
"Cancer therapies are expensive. The new software will help to make a better assessment as to when expensive therapy is justified and also identify those cases in which it is not necessary and the patient can be spared the burden of such treatment," Kenner says.
New tool for "precision medicine"
The so-called “precision medicine”, an advancement of personalized medicine, focusses on the health of individuals. With the aid of molecular biology-based methods, the ideal treatment is found for the individual patient.
This type of medicine is especially promising for the treatment of cancer. Tumors differ from person to person. Pathologists investigate tumor tissue on the molecular level and thus establish the most suitable type of therapy. "For instance, cancer cells bear different surface molecules. A suitable drug must target the correct molecule in order to counteract the growth of the tumor," Kenner explains. "Every patient should receive the most suitable therapy. Only such an approach is ethically justifiable and sensible in economic terms.”
The article „Reliable quantification of protein expression and cellular localization in histological sections“, by Michaela Schlederer, Kristina M. Mueller, Johannes Haybäck, Susanne Heider, Nicole Huttary, Margit Rosner, Markus Hengstschläger, Richard Moriggl, Helmut Dolznig and Lukas Kenner was published on the 11th of July 2014 in the journal PLOS ONE. http://dx.plos.org/10.1371/journal.pone.0100822
About the University of Veterinary Medicine, Vienna
The University of Veterinary Medicine, Vienna in Austria is one of the leading academic and research institutions in the field of Veterinary Sciences in Europe. About 1,200 employees and 2,300 students work on the campus in the north of Vienna which also houses five university clinics and various research sites. Outside of Vienna the university operates Teaching and Research Farms. http://www.vetmeduni.ac.at
Prof. Lukas Kenner
University of Veterinary Medicine, Vienna, Austria (Vetmeduni Vienna)
T +43 664 1188385
Science Communication / Public Relations
University of Veterinary Medicine Vienna (Vetmeduni Vienna)
T +43 1 25077-1153
Dr. Susanna Kautschitsch | idw - Informationsdienst Wissenschaft
Perseus translates proteomics data
27.07.2016 | Max-Planck-Institut für Biochemie
Severity of enzyme deficiency central to favism
26.07.2016 | Universität Zürich
Transparent electronics devices are present in today’s thin film displays, solar cells, and touchscreens. The future will bring flexible versions of such devices. Their production requires printable materials that are transparent and remain highly conductive even when deformed. Researchers at INM – Leibniz Institute for New Materials have combined a new self-assembling nano ink with an imprint process to create flexible conductive grids with a resolution below one micrometer.
To print the grids, an ink of gold nanowires is applied to a substrate. A structured stamp is pressed on the substrate and forces the ink into a pattern. “The...
A new Fraunhofer MEVIS method conveys medical interrelationships quickly and intuitively with innovative visualization technology
On the monitor, a brain spins slowly and can be examined from every angle. Suddenly, some sections start glowing, first on the side and then the entire back of...
Researchers at the U.S. Department of Energy's (DOE) Ames Laboratory have discovered an unusual property of purple bronze that may point to new ways to achieve high temperature superconductivity.
While studying purple bronze, a molybdenum oxide, researchers discovered an unconventional charge density wave on its surface.
Munich Physicists have developed a novel electron microscope that can visualize electromagnetic fields oscillating at frequencies of billions of cycles per second.
Temporally varying electromagnetic fields are the driving force behind the whole of electronics. Their polarities can change at mind-bogglingly fast rates, and...
Breakup of continents with two speed: Continents initially stretch very slowly along the future splitting zone, but then move apart very quickly before the onset of rupture. The final speed can be up to 20 times faster than in the first, slow extension phase.phases
Present-day continents were shaped hundreds of millions of years ago as the supercontinent Pangaea broke apart. Derived from Pangaea’s main fragments Gondwana...
15.07.2016 | Event News
15.07.2016 | Event News
11.07.2016 | Event News
27.07.2016 | Earth Sciences
27.07.2016 | Materials Sciences
27.07.2016 | Earth Sciences