The type of therapy a cancer patient receives, largely depends on the trained eye of a pathologist.
Investigating diseased organs and tissues under the microscope is one of their tasks. However, human judgment is, by its very nature, subject to a certain degree of variation. To enhance the quality of diagnosis, scientists at Vetmeduni Vienna, the Medical University of Vienna and the Ludwig Boltzmann Institute for Cancer Research have developed a software that specifically identifies cell structures and proteins in order to provide reliable diagnoses. The scientists published their data in the journal Plos One.
Together with the company Tissuegnostics, the pathologist Lukas Kenner and his colleagues have developed a software that is able to identify cancer cells in tissue sections and demonstrate the presence of specific biomarkers on cells. The overall information provides a precise picture of the disease and leads to the most suitable treatment.
According to the results of the study, "Two independent pathologists concur with each other only in regard of every third diagnosis."
"The recently developed software offers, for the first time, the option of eliminating the so-called inter-observer-variability, which is the systematic variability of judgement among different observers," chief investigators Lukas Kenner and Helmut Dolznig explain.
Software identifies the severity of cancer
The scientists investigated and analyzed 30 liver cell carcinomas, and clearly assigned these to the categories "negative" or "highly positive" with the help of the software. For this purpose the scientists analyzed the expression of specific proteins like Stat5 and JunB, which play an important role in the emergence of cancer. The software utilizes specific algorithms and highly sensitive digital photography, and is able to more clearly depict the matrix of cells and the cell nucleus than the view achieved by the human eye using a microscope.
Changes in cancer cells can be specified more exactly
"We have been using the software in research for several years. The technology will obviously not replace pathologists, but is a supplementary technology that markedly enhances the reliability of the diagnosis," Kenner states. Kenner also believes that the new technology will help to specify the categories in which in cancer cells are classified with greater accuracy in the future.
"Cancer therapies are expensive. The new software will help to make a better assessment as to when expensive therapy is justified and also identify those cases in which it is not necessary and the patient can be spared the burden of such treatment," Kenner says.
New tool for "precision medicine"
The so-called “precision medicine”, an advancement of personalized medicine, focusses on the health of individuals. With the aid of molecular biology-based methods, the ideal treatment is found for the individual patient.
This type of medicine is especially promising for the treatment of cancer. Tumors differ from person to person. Pathologists investigate tumor tissue on the molecular level and thus establish the most suitable type of therapy. "For instance, cancer cells bear different surface molecules. A suitable drug must target the correct molecule in order to counteract the growth of the tumor," Kenner explains. "Every patient should receive the most suitable therapy. Only such an approach is ethically justifiable and sensible in economic terms.”
The article „Reliable quantification of protein expression and cellular localization in histological sections“, by Michaela Schlederer, Kristina M. Mueller, Johannes Haybäck, Susanne Heider, Nicole Huttary, Margit Rosner, Markus Hengstschläger, Richard Moriggl, Helmut Dolznig and Lukas Kenner was published on the 11th of July 2014 in the journal PLOS ONE. http://dx.plos.org/10.1371/journal.pone.0100822
About the University of Veterinary Medicine, Vienna
The University of Veterinary Medicine, Vienna in Austria is one of the leading academic and research institutions in the field of Veterinary Sciences in Europe. About 1,200 employees and 2,300 students work on the campus in the north of Vienna which also houses five university clinics and various research sites. Outside of Vienna the university operates Teaching and Research Farms. http://www.vetmeduni.ac.at
Prof. Lukas Kenner
University of Veterinary Medicine, Vienna, Austria (Vetmeduni Vienna)
T +43 664 1188385
Science Communication / Public Relations
University of Veterinary Medicine Vienna (Vetmeduni Vienna)
T +43 1 25077-1153
Dr. Susanna Kautschitsch | idw - Informationsdienst Wissenschaft
Cnidarians remotely control bacteria
21.09.2017 | Christian-Albrechts-Universität zu Kiel
Immune cells may heal bleeding brain after strokes
21.09.2017 | NIH/National Institute of Neurological Disorders and Stroke
Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.
The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...
Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...
Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!
When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...
For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.
Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...
MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.
MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems...
19.09.2017 | Event News
12.09.2017 | Event News
06.09.2017 | Event News
21.09.2017 | Physics and Astronomy
21.09.2017 | Life Sciences
21.09.2017 | Health and Medicine