Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Scientists developed new technology for the diagnosis of cancer cells

14.07.2014

The type of therapy a cancer patient receives, largely depends on the trained eye of a pathologist.

Investigating diseased organs and tissues under the microscope is one of their tasks. However, human judgment is, by its very nature, subject to a certain degree of variation. To enhance the quality of diagnosis, scientists at Vetmeduni Vienna, the Medical University of Vienna and the Ludwig Boltzmann Institute for Cancer Research have developed a software that specifically identifies cell structures and proteins in order to provide reliable diagnoses. The scientists published their data in the journal Plos One.


The tissue section through a prostate reveals whether cancer cells are present.

Photo: Lukas Kenner

Together with the company Tissuegnostics, the pathologist Lukas Kenner and his colleagues have developed a software that is able to identify cancer cells in tissue sections and demonstrate the presence of specific biomarkers on cells. The overall information provides a precise picture of the disease and leads to the most suitable treatment.

According to the results of the study, "Two independent pathologists concur with each other only in regard of every third diagnosis."

"The recently developed software offers, for the first time, the option of eliminating the so-called inter-observer-variability, which is the systematic variability of judgement among different observers," chief investigators Lukas Kenner and Helmut Dolznig explain.

Software identifies the severity of cancer

The scientists investigated and analyzed 30 liver cell carcinomas, and clearly assigned these to the categories "negative" or "highly positive" with the help of the software. For this purpose the scientists analyzed the expression of specific proteins like Stat5 and JunB, which play an important role in the emergence of cancer. The software utilizes specific algorithms and highly sensitive digital photography, and is able to more clearly depict the matrix of cells and the cell nucleus than the view achieved by the human eye using a microscope.

Changes in cancer cells can be specified more exactly

"We have been using the software in research for several years. The technology will obviously not replace pathologists, but is a supplementary technology that markedly enhances the reliability of the diagnosis," Kenner states. Kenner also believes that the new technology will help to specify the categories in which in cancer cells are classified with greater accuracy in the future.

"Cancer therapies are expensive. The new software will help to make a better assessment as to when expensive therapy is justified and also identify those cases in which it is not necessary and the patient can be spared the burden of such treatment," Kenner says.

New tool for "precision medicine"

The so-called “precision medicine”, an advancement of personalized medicine, focusses on the health of individuals. With the aid of molecular biology-based methods, the ideal treatment is found for the individual patient.

This type of medicine is especially promising for the treatment of cancer. Tumors differ from person to person. Pathologists investigate tumor tissue on the molecular level and thus establish the most suitable type of therapy. "For instance, cancer cells bear different surface molecules. A suitable drug must target the correct molecule in order to counteract the growth of the tumor," Kenner explains. "Every patient should receive the most suitable therapy. Only such an approach is ethically justifiable and sensible in economic terms.”

The article „Reliable quantification of protein expression and cellular localization in histological sections“, by Michaela Schlederer, Kristina M. Mueller, Johannes Haybäck, Susanne Heider, Nicole Huttary, Margit Rosner, Markus Hengstschläger, Richard Moriggl, Helmut Dolznig and Lukas Kenner was published on the 11th of July 2014 in the journal PLOS ONE. http://dx.plos.org/10.1371/journal.pone.0100822

About the University of Veterinary Medicine, Vienna
The University of Veterinary Medicine, Vienna in Austria is one of the leading academic and research institutions in the field of Veterinary Sciences in Europe. About 1,200 employees and 2,300 students work on the campus in the north of Vienna which also houses five university clinics and various research sites. Outside of Vienna the university operates Teaching and Research Farms. http://www.vetmeduni.ac.at

Scientific Contact:
Prof. Lukas Kenner
University of Veterinary Medicine, Vienna, Austria (Vetmeduni Vienna)
T +43 664 1188385
lukas.kenner@meduniwien.ac.at

Released by:
Susanna Kautschitsch
Science Communication / Public Relations
University of Veterinary Medicine Vienna (Vetmeduni Vienna)
T +43 1 25077-1153
susanna.kautschitsch@vetmeduni.ac.at

Weitere Informationen:

http://www.vetmeduni.ac.at/en/infoservice/presseinformation/press-releases-2014/...

Dr. Susanna Kautschitsch | idw - Informationsdienst Wissenschaft

Further reports about: Medicine Veterinary Vetmeduni cell structures diagnosis pathologists proteins tumor tissue

More articles from Life Sciences:

nachricht How to become a T follicular helper cell
31.07.2015 | La Jolla Institute for Allergy and Immunology

nachricht Heating and cooling with light leads to ultrafast DNA diagnostics
31.07.2015 | University of California - Berkeley

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Quantum Matter Stuck in Unrest

Using ultracold atoms trapped in light crystals, scientists from the MPQ, LMU, and the Weizmann Institute observe a novel state of matter that never thermalizes.

What happens if one mixes cold and hot water? After some initial dynamics, one is left with lukewarm water—the system has thermalized to a new thermal...

Im Focus: On the crest of the wave: Electronics on a time scale shorter than a cycle of light

Physicists from Regensburg and Marburg, Germany have succeeded in taking a slow-motion movie of speeding electrons in a solid driven by a strong light wave. In the process, they have unraveled a novel quantum phenomenon, which will be reported in the forthcoming edition of Nature.

The advent of ever faster electronics featuring clock rates up to the multiple-gigahertz range has revolutionized our day-to-day life. Researchers and...

Im Focus: Superfast fluorescence sets new speed record

Plasmonic device has speed and efficiency to serve optical computers

Researchers have developed an ultrafast light-emitting device that can flip on and off 90 billion times a second and could form the basis of optical computing.

Im Focus: Unlocking the rice immune system

Joint BioEnergy Institute study identifies bacterial protein that is key to protecting rice against bacterial blight

A bacterial signal that when recognized by rice plants enables the plants to resist a devastating blight disease has been identified by a multi-national team...

Im Focus: Smarter window materials can control light and energy

Researchers in the Cockrell School of Engineering at The University of Texas at Austin are one step closer to delivering smart windows with a new level of energy efficiency, engineering materials that allow windows to reveal light without transferring heat and, conversely, to block light while allowing heat transmission, as described in two new research papers.

By allowing indoor occupants to more precisely control the energy and sunlight passing through a window, the new materials could significantly reduce costs for...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

3rd Euro Bio-inspired - International Conference and Exhibition on Bio-inspired Materials

23.07.2015 | Event News

Clash of Realities – International Conference on the Art, Technology and Theory of Digital Games

10.07.2015 | Event News

World Conference on Regenerative Medicine in Leipzig: Last chance to submit abstracts until 2 July

25.06.2015 | Event News

 
Latest News

Tool making and additive technology exhibition: Fraunhofer IPT at Formnext

31.07.2015 | Trade Fair News

First Siemens-built Thameslink train arrives in London

31.07.2015 | Transportation and Logistics

California 'rain debt' equal to average full year of precipitation

31.07.2015 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>