Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Scientists 'reprogram' mouse fat cells into clinically useful stem cells

27.07.2010
Australian scientists from the Monash Institute of Medical Research have "reprogrammed" adult mouse fat cells and neural cells to become stem cells that can differentiate into a variety of different cells (pluripotency).

The cells, called "induced pluripotent stem cells" (iPS), are nearly identical to the naturally occurring pluripotent stems cells, such as embryonic stem cells, which are highly pluripotent, in short supply and their access restricted in the U.S.

The study is published in issue 19(5) of Cell Transplantation and is now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/ .

"Induced pluripotent stem cells have revolutionized cell reprogramming," said the study's lead author, Dr. Paul J. Verma. "One challenge is to find the most appropriate cell for reprogramming. Our study demonstrated that both neural stem cells (NSCs) and adipose tissue-derived cells (ADCs) from adult mice expressed genetic pluripotency and could differentiate into the three germ layers, endoderm, mesoderm and ectoderm. The ADCs were the most amenable to reprogramming."

According to Dr. Verma, iPS cells have been shown to have many of the hallmarks of embryonic stem cells. Choosing which cells were best for reprogramming required looking at the ease of access and ease of derivation and growth of the cells in vitro. They concluded that it was likely that certain iPS cell lines will have a "higher propensity to differentiate into certain lineages (cell types)."

"This variation may be related to different levels of programming achieved," added Dr. Verma. "Many different cell types need to be investigated to generate many iPS lines for specific differentiation and different research purposes."

The research team concluded that ADCs represent a more clinically relevant cell type and that fat tissue can be easily accessed and grown easily and rapidly in cultures. Fat tissue cells, when reprogrammed, can also be prolific. The authors cited a study previously published in Cell Transplantation (16:9) suggesting that 100 ml of human fat tissue could yield one million clinically useful stem cells.

Their work takes the development of iPS cells a step closer toward their eventual clinical use in treating human diseases.

"There is considerable potential in the generation of iPS cells for the treatment of a number of disorders" said Dr. Paul Sanberg, coeditor-in-chief and Director of the Center Of Excellence for Aging and Brain Repair at the University of South Florida. "Finding the optimal source of cells to start with, is of paramount importance and this study provides reassuring data on a highly favorable source".

Contact: Dr. Paul J. Verma, Monash Institute of Medical Research 2731 Wright St. Clayton 3172 VIC Australia. Tel:+ 61 3 9594 7000; Fax: +61 3 9594 7416 Email: Paul.Verma@med.monash.edu.au

The editorial offices for Cell Transplantation are at the Center of Excellence for Aging and Brain Repair, College of Medicine, the University of South Florida and the Diabetes Research Institute, University of Miami Miller School of Medicine. Contact, David Eve, PhD. at celltransplantation@gmail.com or Camillo Ricordi, MD at ricordi@miami.edu

News Release by Randolph Fillmore, www.sciencescribe.net

David Eve | EurekAlert!
Further information:
http://www.ingentaconnect.com/content/cog/ct/
http://www.sciencescribe.net

More articles from Life Sciences:

nachricht Complementing conventional antibiotics
24.05.2018 | Goethe-Universität Frankfurt am Main

nachricht Building a brain, cell by cell: Researchers make a mini neuron network (of two)
23.05.2018 | Institute of Industrial Science, The University of Tokyo

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

When corals eat plastics

24.05.2018 | Ecology, The Environment and Conservation

Surgery involving ultrasound energy found to treat high blood pressure

24.05.2018 | Medical Engineering

First chip-scale broadband optical system that can sense molecules in the mid-IR

24.05.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>