Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


It’s Not Easy Being Gene Suppressed

Frogs around the world are dying from a fungal pathogen perhaps because they don’t realize they are sick.

In a study conducted at the University of Idaho, scientists found that the immune system of the study’s frog species failed to respond to the chytrid fungus known as Batrachochytrium dendrobatidis (Bd). In fact, it appears the fungal infection may actually suppress its victim’s immune system.

The findings are reported in a paper recently published in the Public Library of Science online edition (PLoS ONE), an interactive open-access journal for the communication of all peer-reviewed scientific and medical research.

“The biggest thing we found was a surprising lack of response by the frogs,” said Erica Bree Rosenblum, assistant professor of biological sciences and lead author of the study. “If you are hit with a deadly disease, you would expect that your body would do something about it. But we found that these frogs are not turning on immune function genes the way you would expect them to.”

Bd is an ancient fungus that only recently began killing frogs around the world. It lives inside of a frog’s skin, wreaking havoc by some unknown mechanism. Previous studies have shown that once Bd is introduced to a habitat, up to 50 percent of amphibian species and 80 percent of individuals can die within one year.

Scientists do not know how or why Bd kills its host, so Rosenblum is attacking the problem through genetics.

The study examined gene expression in the skin, liver and spleen of infected frogs of the species Silurana (Xenopus) tropicalis – a species highly susceptible to Bd – both three days after exposure and shortly before death. The skin was studied to determine what mechanisms cause frogs to die, while the liver and spleen were chosen to study the immune system’s response to the fungus.

Results found that not only are the genes related to immune response in infected frogs not turning on, but those genes are actually being suppressed.

“And that is the exact opposite of what one would expect to find,” said Rosenblum.

Besides the immune system, the study also looked at the frog’s skin to determine what processes, if any, are responsible for what amounts to a skin infection killing a vertebrate. This is a rare occurrence because, after all, humans don’t die from fungal skin conditions such as ringworm. So why should a fungal skin infection cause frogs to croak?

Though the study did not find any smoking guns, it did point to some disrupted genes in the frog’s skin; an organ that is much more important to an aquatic animal’s health than a land lover’s.

Other disrupted genes seem to affect cellular detoxification, which could make the frogs susceptible to toxins created by the fungus, the natural environment, or both.

According to Rosenblum, though this study is not good news for frogs, and only encompasses one species in a controlled environment, it is an important piece of the puzzle.

“This study is not the answer but it is a necessary first step to help us find the answer, said Rosenblum. “The next step in finding this answer involves further research on the generality of these findings in other species and other conditions.”

The research paper can be found online at:

Ken Kingery | Newswise Science News
Further information:

More articles from Life Sciences:

nachricht Novel mechanisms of action discovered for the skin cancer medication Imiquimod
21.10.2016 | Technische Universität München

nachricht Second research flight into zero gravity
21.10.2016 | Universität Zürich

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Resolving the mystery of preeclampsia

21.10.2016 | Health and Medicine

Stanford researchers create new special-purpose computer that may someday save us billions

21.10.2016 | Information Technology

From ancient fossils to future cars

21.10.2016 | Materials Sciences

More VideoLinks >>>