Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Role of gene regulator in skeletal muscles demonstrated

03.06.2011
Fast muscles, such as the thigh muscle in a sprinter, deliver energy quickly but fatigue quickly. Slow muscles, such as the soleus muscle in the lower calf, are less forceful but important for posture and endurance.

Researchers from the University of Texas Southwestern Medical Center and Virginia Tech have discovered one gene regulator that maintains the fast muscle type and inhibits the development of a slow muscle type.

The research was posted in the Proceedings of the National Academy of Sciences' online early edition on June 1 in the article, "Concerted regulation of myofiber-specific gene expression and muscle performance by the transcriptional repressor Sox6," by Daniel Quiat of UT Southwestern, Kevin Voelker of Virginia Tech, Jimin Pei and Nick V. Grishin of UT Southwestern, Robert Grange of Virginia Tech, and Rhonda Bassel-Duby and Eric N. Olson of UT Southwestern.

"Based on previous studies by our group and others, we knew that a gene regulator called Sox6 promotes development of fast muscle in the embryo," said Olson, professor of molecular biology. "But the function of Sox6 in adult muscle was unknown."

By studying adult mice that lacked Sox6 in fast muscles, the researchers observed that fast muscle took on the performance attributes of slow muscles.

Virginia Tech's role in the research project was to measure muscle performance. "We demonstrated experimentally that there were functional changes that supported the development of slow muscle," said Grange, associate professor of human nutrition, food, and exercise in the College of Agriculture and Life Sciences. At Virginia Tech, he worked with Voelker, a postdoctoral associate in the department.

"The most obvious change is the speed at which muscle can shorten," said Grange. "Fast muscle shortens quickly; but, in the absence of Sox6, our measurements showed that fast muscle shortened more slowly and the muscle was less fatigued after contracting for several minutes. Both of these muscle performance changes demonstrated that a fast muscle that lacked Sox6 became more like a slow muscle."

"Skeletal muscles can adapt based on the stress imposed," explains Grange. "For example, if you lift weights, your muscles become stronger; if you run long distances, your muscles become less fatigued. What we don't yet know fully is how adaptations occur at the gene level and protein level in response to these different stresses. The current study is an important step to understand how muscle adaptation occurs."

Although applications of the new information are distant, Grange points out, "The more you know about how the body works, the easier it is to keep it healthy."

"We might be able to manipulate gene regulators by training in a certain way. We don't know what that is, but that is one of the objectives. From a muscle disease perspective, there may be characteristics that lead back to the proteins that control adaptations, such as Sox6," said Grange.

"You cannot have adaptations in the muscle unless there are changes in the genes turned on and those turned off. The genes turned on produce the proteins responsible for the muscle adaptation" he said. "The most exciting aspect of the study was that we clearly demonstrated changes in muscle function from a fast type to a slow type of skeletal muscle that was dependent on the absence of Sox6."

Link to the article: http://www.pnas.org/content/early/2011/05/31/1107413108.abstract

Susan Trulove | EurekAlert!
Further information:
http://www.vt.edu

More articles from Life Sciences:

nachricht BigH1 -- The key histone for male fertility
14.12.2017 | Institute for Research in Biomedicine (IRB Barcelona)

nachricht Guardians of the Gate
14.12.2017 | Max-Planck-Institut für Biochemie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

Im Focus: Successful Mechanical Testing of Nanowires

With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong

Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Plasmonic biosensors enable development of new easy-to-use health tests

14.12.2017 | Health and Medicine

New type of smart windows use liquid to switch from clear to reflective

14.12.2017 | Physics and Astronomy

BigH1 -- The key histone for male fertility

14.12.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>