Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Resurrected mammoth blood very cool

03.05.2010
A team of international researchers has brought the primary component of mammoth blood back to life using ancient DNA preserved in bones from Siberian specimens 25,000 to 43,000 years old.

Studies of recreated mammoth haemoglobin, published today (Monday 3 May) in Nature Genetics, reveal special evolutionary adaptations that allowed the mammoth to cool its extremities down in harsh Arctic conditions to minimise heat loss.

"It has been remarkable to bring a complex protein from an extinct species, such as the mammoth, back to life," says Professor Alan Cooper, Director of the Australian Centre for Ancient DNA (ACAD) at the University of Adelaide, where the mammoth haemoglobin sequences were determined.

"This is true palaeobiology, as we can study and measure how these animals functioned as if they were alive today."

Professor Cooper is an Australian Research Council Future Fellow and a member of the University's Environment Institute.

"We've managed to uncover physiological attributes of an animal that hasn't existed for thousands of years," says team leader Professor Kevin Campbell of the University of Manitoba, Canada. "Our approach opens the way to studying the biomolecular and physiological characteristics of extinct species, even for features that leave no trace in the fossil record."

The project began over seven years ago when Professor Campbell contacted Professor Cooper, who was then based at the University of Oxford, to suggest resurrecting mammoth haemoglobin.

"At the time, I thought 'what a great idea' – but it's never going to work," says Professor Cooper. "Still, bringing an extinct protein back to life is such an important concept, we've got to try it."

The team converted the mammoth haemoglobin DNA sequences into RNA, and inserted them into modern-day E. coli bacteria, which then manufactured the authentic mammoth protein.

"The resulting haemoglobin molecules are no different than 'going back in time' and taking a blood sample from a real mammoth," says Professor Campbell.

The team used modern scientific physiological tests and chemical modelling to characterise the biochemical properties that confer mammoths with physiological cold tolerance.

Team member Professor Roy Weber of the University of Aarhus, Denmark, who performed the physiological testing on the mammoth proteins, says the findings help show how the mammoth survived the extreme Arctic cold.

"Three highly unusual changes in the protein sequence allowed the mammoth's blood to deliver oxygen to cells even at very low temperatures, something that indicates adaptation to the Arctic environment," Professor Weber says.

"We can now apply similar approaches to other extinct species, such as Australian marsupials," says team member Dr Jeremy Austin, ACAD Deputy Director, who is currently using ancient DNA to study the evolution and extinction of the thylacine and Tasmanian Devil.

Professor Alan Cooper | EurekAlert!
Further information:
http://www.adelaide.edu.au

More articles from Life Sciences:

nachricht Researchers develop eco-friendly, 4-in-1 catalyst
25.04.2017 | Brown University

nachricht Transfecting cells gently – the LZH presents a GNOME prototype at the Labvolution 2017
25.04.2017 | Laser Zentrum Hannover e.V.

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

NASA's Fermi catches gamma-ray flashes from tropical storms

25.04.2017 | Physics and Astronomy

Researchers invent process to make sustainable rubber, plastics

25.04.2017 | Materials Sciences

Transfecting cells gently – the LZH presents a GNOME prototype at the Labvolution 2017

25.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>