Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers pursuing arthritis protein

10.01.2014
Inflammation Researchers at the University of Copenhagen have investigated a special protein that appears in inflammatory diseases such as arthritis, inflammatory bowel disease and psoriasis. The findings have just been published in the scientific journal PLOS ONE.

The healthy blood cells stem from the blood bank at Rigshospitalet in Copenhagen, and more than 50 donors have been examined with the same result. Photo: Blood cells, Bruce Wetzel, Harry Schaefer, National Cancer Institute.

Chronic inflammation poses something of a mystery for researchers. If we become infected, the body immediately takes steps to repair and tidy it up. This process manifests itself as inflammation, which stems from a high level of activity in the immune cells, the body’s defence against bacteria and viruses.

But it does not always go according to plan. Every so often, the body’s immune system over-reacts, and the inflammation develops into a chronic condition, resulting in diseases such as arthritis, inflammatory bowel disease and psoriasis. However, researchers are now a step closer to understanding what happens when the immune system over-reacts and causes chronic inflammation.

The healthy blood cells stem from the blood bank at Rigshospitalet in Copenhagen, and more than 50 donors have been examined with the same result. Photo: Blood cells, Bruce Wetzel, Harry Schaefer, National Cancer Institute.

“Through analysing blood cells, we have observed that a particular protein called TL1A can get healthy cells to behave like those we see in chronic inflammation. This is bringing us closer to unlocking the mystery of inflammation,” says Kirsten Reichwald, PhD student at the Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen. The results have been published in PLOS ONE.

Biological treatment fights arthritis

Today, doctors can use so-called biological medicines for treating arthritis, which has radically changed the outlook for patients. Biological treatment works by impeding the harmful substances that are partly responsible for advancing the chronic inflammation in the body. Almost 40 per cent of arthritis patients experience a positive effect when taking biological medicines.

“Existing biological treatment means that doctors today can halt the diseases instead of just relieving the symptoms,” explains Kirsten Reichwald.

However, in order to block the right substances, doctors need detailed information about the processes that cause chronic inflammation. The researchers therefore studied cells from 50 blood donors from the blood bank at Rigshospitalet in Copenhagen, and concluded that the protein TL1A has a key role in the development of the inflammation.

“Our latest findings tell us, that the TL1A protein takes part in driving the inflammation, and therefore it makes sense to try and block the protein with biological medicines,” says Kirsten Reichwald, who hopes that her future research will help to provide even more specific knowledge about inflammation.

Contact:

Kirsten Reichwald
Cell:+45 61 68 65 76

Kirsten Reichwald | EurekAlert!
Further information:
http://www.ku.dk

More articles from Life Sciences:

nachricht Canola genome sequence reveals evolutionary ‘love triangle’
22.08.2014 | University of Georgia

nachricht Biologists Reprogram Skin Cells to Mimic Rare Disease
22.08.2014 | Johns Hopkins Medicine

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Anzeige

Anzeige

Event News

MEDICA EDUCATION CONFERENCE: Bessere Behandlung dank Biomarker

21.08.2014 | Event News

Mathematics and Computer Science - Key Disciplines in Developing Countries as well?

20.08.2014 | Event News

5th Technical Conference "Subsoil Analysis, Ground Improvement and Wind Turbine Foundations"

13.08.2014 | Event News

 
Latest News

Enabling a new future for cloud computing

22.08.2014 | Information Technology

Electric Sparks May Alter Evolution of Lunar Soil

22.08.2014 | Physics and Astronomy

Despite a significant reduction in smog-producing toxins, the Greater Toronto Area still violates Canada's standards for ozone air pollution

22.08.2014 | Studies and Analyses

VideoLinks
B2B-VideoLinks
More VideoLinks >>>