Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers identify proteins that indicate which kidney tumors are most likely to spread

06.12.2012
Discovery will help physicians recognize which tumours are going to behave more aggressively
Researchers at St. Michael's hospital have identified 29 proteins that are likely to be involved in the spread of kidney cancer. The discovery will help physicians recognize which tumours are going to behave more aggressively and provide those patients with more intensive treatment and closer followup.

"Metastatic renal cell carcinoma is one of the most treatment-resistant malignancies and patients have dismal prognosis," said Dr. George M Yousef, a laboratory pathologist. "Identification of markers that can predict the potential of metastases will have a great impact on improvement patient outcomes.

Dr. Yousef's research appears online in the journal Molecular & Cellular Proteomics.

Kidney cancer in general is very aggressive and has a high chance of metastasis, or spreading to other organs. The five-year survival rate for metastasized kidney cancer is less than 10 per cent. Although imaging technology has led to increased detection of kidney tumours, 25 to 30 per cent have already spread by the time they are found.

Using a mass spectrometer, Dr. Yousef identified 29 proteins that change when cancer cells spread from the original site of the kidney tumour. All 29 proteins have been previously been linked to other malignancies.

Dr. Yousef said if physicians can determine which kidney tumours have those proteins, and are likely to spread, they can monitor and treat those patients more aggressively. Patients who don't have those proteins and biomarkers might not have to undergo costly and intensive treatment or surgery.

The next steps would be to find ways to stop the proteins from turning on and triggering the metastasis.

This study was supported by grants from the Canadian Cancer Society, the Ontario Ministry of Research and Innovation, the Kidney Foundation of Canada and the Cancer Research Society.

About St. Michael's Hospital
St. Michael's Hospital provides compassionate care to all who enter its doors. The hospital also provides outstanding medical education to future health care professionals in more than 23 academic disciplines. Critical care and trauma, heart disease, neurosurgery, diabetes, cancer care, and care of the homeless are among the Hospital's recognized areas of expertise. Through the Keenan Research Centre and the Li Ka Shing International Healthcare Education Center, which make up the Li Ka Shing Knowledge Institute, research and education at St. Michael's Hospital are recognized and make an impact around the world. Founded in 1892, the hospital is fully affiliated with the University of Toronto.

For more information or to interview Dr.Yousef, please contact:

Leslie Shepherd
Manager, Media Strategy
St. Michael's Hospital
Phone: 416-864-6094 or 647-300-1753
shepherdl@smh.ca
Inspired Care. Inspiring Science.

Leslie Shepherd | EurekAlert!
Further information:
http://www.smh.ca

More articles from Life Sciences:

nachricht Making fuel out of thick air
08.12.2017 | DOE/Argonne National Laboratory

nachricht ‘Spying’ on the hidden geometry of complex networks through machine intelligence
08.12.2017 | Technische Universität Dresden

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

Im Focus: Successful Mechanical Testing of Nanowires

With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong

Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...

Im Focus: Virtual Reality for Bacteria

An interdisciplinary group of researchers interfaced individual bacteria with a computer to build a hybrid bio-digital circuit - Study published in Nature Communications

Scientists at the Institute of Science and Technology Austria (IST Austria) have managed to control the behavior of individual bacteria by connecting them to a...

Im Focus: A space-time sensor for light-matter interactions

Physicists in the Laboratory for Attosecond Physics (run jointly by LMU Munich and the Max Planck Institute for Quantum Optics) have developed an attosecond electron microscope that allows them to visualize the dispersion of light in time and space, and observe the motions of electrons in atoms.

The most basic of all physical interactions in nature is that between light and matter. This interaction takes place in attosecond times (i.e. billionths of a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Midwife and signpost for photons

11.12.2017 | Physics and Astronomy

How do megacities impact coastal seas? Searching for evidence in Chinese marginal seas

11.12.2017 | Earth Sciences

PhoxTroT: Optical Interconnect Technologies Revolutionized Data Centers and HPC Systems

11.12.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>