Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers identify main genes responsible for asthma attacks in children

18.11.2013
An international team spearheaded by researchers from the University of Copenhagen has identified the genes that put some children at particularly high risk of serious asthma attacks, including one not previously suspected of being implicated in the disease.

In the long term, these new findings are expected to help improve treatment options for the disease, which represents a high cost for families and society alike.

Asthma is the most frequent chronic disease in children and also the most common reason for Danish children being admitted to hospital. Very young children are at especially high risk of severe asthma attacks requiring hospitalisation.

This is hard on both child and family and severely strains society's resources. Nonetheless, doctors still have insufficient knowledge about asthma attacks in infants, making the condition difficult to prevent and treat. It is hoped that the recent research findings will help change this.

... more about:
»COPSAC »DNA »asthma attack »asthma attacks

An international team spearheaded by researchers from the University of Copenhagen have now identified the genes that put some children at risk of experiencing severe asthma attacks. The results have been published in the prestigious scientific journal Nature Genetics.

"Our results show that asthma attacks requiring young children to be hospitalised are usually genetically related. Genes play a far greater role in children with asthma than in adults. By screening children's DNA we've discovered that a gene called CDHR3, which was previously unassociated with the disease, plays a key role for the development of asthma, particularly in the very early years of life.

Our study supports the theory that asthma is not just a single disease, but a complex of several sub-types that should be genetically mapped and understood individually if we are to prevent and treat the disease properly in future," says Klaus Bønnelykke, MD, PhD. He works for the Copenhagen Studies of Asthma in Childhood (COPSAC), the Danish Pediatric Asthma Center, Copenhagen University Hospital.

The researchers have studied the genes of 1,200 young children aged between two and six who had been hospitalised several times because of severe asthma attacks, and compared them with 2,500 healthy people.

Individualised treatment

Today doctors use the same medication to treat different types and degrees of asthma, but the researchers hope that improved understanding of the sub-types of the disease will pave the way for individualised treatment in future.

"Although good asthma medication is available today, it doesn't work for everyone. Specifically we need effective medicine to prevent very young children from being hospitalised and to treat them once they have been admitted. That's why we started looking at this particular group. Because asthma symptoms are fairly similar in all children, doctors tend to approach the condition in the same way. However, in reality asthma has many different underlying mechanisms, which need to be individually mapped," says Klaus Bønnelykke. He explains that to date researchers have focused on various theories about asthma attack prevention in young children, for example, recommending breastfeeding and avoiding pets and dust mites in the home.

"We know that children exposed to smoking have a higher risk of asthma attacks, but beyond that, none of our advice has really helped, and we won't make any progress until we understand the individual sub-types of asthma and their underlying mechanisms. In this respect knowledge about risk genes is an important step in the right direction," he points out.

Large volume of data

The study was headed by Klaus Bønnelykke and his colleague Hans Bisgaard, Professor of Paediatrics at the University of Copenhagen, chief physician of the Copenhagen Studies of Asthma in Childhood (COPSAC) and head of the Danish Paediatric Asthma Center. The study was conducted in collaboration with various research groups, including the Danish Centre for Neonatal Screening, Statens Serum Institut, Copenhagen, and Center for Biological Sequence Analysis (CBS), Technical University of Denmark,, as well as research teams in the USA, Spain, the UK and the Netherlands.

The study was based on examinations of 1,200 Danish children hospitalised for asthma and 2,500 healthy individuals. Two- to six-year-old children who had been hospitalised at least twice were identified in the hospital records. Their DNA was then screened for risk genes, and subsequent studies of children from Denmark and abroad confirmed the discovery of a new risk gene (CDHR3).

Contact:

Klaus Bønnelykke, MD, PhD
COPSAC, Danish Paediatric Asthma Center, the Faculty of Health and Medical Sciences
Tel.: +45 31 90 32 59
Mail: kb@copsac.com
About asthma:
Asthma means shortness of breath. It is a respiratory disorder that can affect people of all ages – children, adults and the elderly. The symptoms often manifest as bouts of coughing, breathlessness and wheezing. You can be genetically disposed to the disease, but beyond that the reasons some people get asthma are unknown. For most sufferers, asthma is a chronic condition lasting many years. Some people grow out of the disease while others find themselves symptom-free and needing no medication for a period, after which their asthma returns. The new research findings indicate that more disease sub-type mapping is needed in order to improve future treatment and prevention options. Source: Astma-Allergi Danmark and Klaus Bønnelykke, PhD, Danish Paediatric Asthma Center, University of Copenhagen

About the CDHR3 gene

CDHR3 impacts the lungs directly, and the new research results indicate that it plays a particularly important role in the lungs of young children with severe asthma. Over time the researchers hope to be able to map the precise mechanisms involving the gene as well as the environmental factors that trigger activation of the gene in some children. The goal is to be able to prevent and treat the disease with customised medication.

Klaus Bønnelykke | EurekAlert!
Further information:
http://www.ku.dk/

Further reports about: COPSAC DNA asthma attack asthma attacks

More articles from Life Sciences:

nachricht The birth of a new protein
20.10.2017 | University of Arizona

nachricht Building New Moss Factories
20.10.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Terahertz spectroscopy goes nano

20.10.2017 | Information Technology

Strange but true: Turning a material upside down can sometimes make it softer

20.10.2017 | Materials Sciences

NRL clarifies valley polarization for electronic and optoelectronic technologies

20.10.2017 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>