In the study, published online Jan. 8 in Science Express, researchers reported that Stat3, a protein previously known to control the activity of genes by acting in the cell nucleus, also plays a key role in cellular energy production.
The team examined oxygen consumption in cultured cells and hearts of mice. They discovered that when Stat 3 protein was missing, cells consumed less oxygen and produced less ATP, the key molecular form of cellular energy. The findings revealed that Stat3 is necessary for the function of the mitochondrial electron transport chain that generates ATP. Changes in energy production and expenditure are essential to maintain cellular homeostasis.
“We found evidence that Stat3 is present in the mitochondria and that it serves to control the production of ATP,” said principal investigator Andrew C. Larner, M.D., Ph.D., professor of biochemistry and molecular biology in the VCU School of Medicine, and co-leader of the Immune Mechanisms research program at the VCU Massey Cancer Center.
“We have described a new pathway by which generation of ATP is regulated. This pathway could suggest new ways for Stat3 to be therapeutically manipulated to treat a variety of diseases where there are imbalances between energy generation and energy demands such as occurs in cancer and heart disease,” he said.
Next, the team will conduct studies to determine the downstream targets of Stat3 in the mitochondria and identify the physiological role of Stat3 that is localized to the mitochondria in heart disease and cancer.
This work was supported by grants from National Institutes of Health.
Larner worked with an international team including researchers from the VCU School of Medicine; Cleveland State University; Biogen Idec Inc., The Cleveland Clinic Lerner Research Institute, Indiana School of Medicine, Case Western Reserve University, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Jagiellonian University in Krakow, Poland, and the University of Hyderabad in Hyderabad, India.
About VCU and the VCU Medical Center:
Virginia Commonwealth University is the largest university in Virginia and ranks among the top 100 universities in the country in sponsored research. Located on two downtown campuses in Richmond, VCU enrolls 32,000 students in 205 certificate and degree programs in the arts, sciences and humanities. Sixty-five of the programs are unique in Virginia, many of them crossing the disciplines of VCU’s 15 schools and one college. MCV Hospitals and the health sciences schools of Virginia Commonwealth University compose the VCU Medical Center, one of the nation’s leading academic medical centers.
Sathya Achia Abraham | EurekAlert!
Polymers Based on Boron?
18.01.2018 | Julius-Maximilians-Universität Würzburg
Bioengineered soft microfibers improve T-cell production
18.01.2018 | Columbia University School of Engineering and Applied Science
What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...
For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.
Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.
No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...
Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.
Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...
The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...
08.01.2018 | Event News
11.12.2017 | Event News
08.12.2017 | Event News
18.01.2018 | Life Sciences
18.01.2018 | Life Sciences
18.01.2018 | Earth Sciences