A team of researchers from the Institute for Research in Immunology and Cancer (IRIC) of the University of Montreal have made significant progress in the understanding of blood-producing (hematopoietic) stem cells.
The study led by IRIC Chief Executive Officer and Scientific Director, Dr. Guy Sauvageau, identifies factors that control the production of hematopoietic stem cells. Published in the journal Cell Stem Cell, the research offers interesting insight critical to the development of novel regenerative therapies and treatments for leukemia.
Hematopoietic stem cells (HSCs) are located within the bone marrow and serve as a reservoir for the production of all blood cells. A disruption in this process can have dire consequences leading either to a depleted blood cell population which can cause severe immune deficiencies, or excessive proliferation of blood cells which can trigger the development of leukemia. At the moment, relatively little is known about what controls this production.
The current study aims to understand the roles of various proteins that are present in HSCs and their impact on blood production. Researchers found that three proteins (Msi2, Pard6a and Prkcz) help blood cells to regenerate. That is, when HSCs lack these proteins, blood cells have a reduced capacity to regenerate themselves. Results from a fourth protein, Prox1, showed the reverse effect: their presence hinders the reproduction of blood cells.
"Understanding which proteins control the production of blood-making stem cells is crucial knowledge for designing therapies for diseases caused by unruly HSCs" explains Dr. Sauvageau, "Now that we recognize the key roles that these proteins play, we can evaluate their potential as therapeutic targets to treat a variety of diseases such as leukemia."
Researcher & Financing
Dr. Guy Sauvageau holds the Canada Research Chair in the Molecular Genetics of Normal and Cancer Cells. The research received funding from the Canadian Institutes for Health Research.
Kristin J. Hope, Sonia Cellot, Stephen B. Ting, Tara MacRae, Nadine Mayotte, Norman N. Iscove, and Guy Sauvageau. An RNAi Screen Identifies Msi2 and Prox1 as Having Opposite Roles in the Regulation of Hematopoietic Stem Cell Activity. Cell Stem Cell, Volume: 7; Issue: 1; Manuscript: 682; DOI: 10.1016
On the Web:IRIC: www.iric.ca
Carolyne Lord | EurekAlert!
Link Discovered between Immune System, Brain Structure and Memory
26.04.2017 | Universität Basel
Researchers develop eco-friendly, 4-in-1 catalyst
25.04.2017 | Brown University
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
26.04.2017 | Life Sciences
26.04.2017 | Physics and Astronomy
26.04.2017 | Earth Sciences