In a study published in the September issue of the journal Cell Stem Cell, investigators found that the low-oxygen microenvironments that ordinarily deprive and starve other kinds of cells are tolerated by a type of stem cell used as the primary material for bone-marrow transplantation.
These cells, called hematopoietic stem cells, are found in marrow and can replicate quickly. Once transplanted, they eventually develop into blood and other types of cells. Their ability to self-renew before they transform into blood forms the basis of their usefulness for bone-marrow transplants.
"The cells convert glucose, or sugars, into energy rather than using oxygen to release energy," said Dr. Hesham Sadek, assistant professor of internal medicine at UT Southwestern and senior author of the study "They use glycolysis instead of mitochondrial oxidative phosphorylation to meet their energy demands."
Dr. Sadek and his team sought to understand how hematopoietic cells regulate their metabolism in spite of their inhospitable environment and found the cells expressed a certain gene in a way that enabled them to function without using oxygen.
Understanding more about the function of stem cells and their ability to self renew might lead to new avenues of encouraging the cells to grow in large numbers outside the body, Dr. Sadek said. For example, a potential bone-marrow donor's cells could be incubated and grown indefinitely, providing stem cells to be used in multiple transplant therapies.
"There have been few studies of the metabolism of stem cells, and our aim was to find out how stem cells can 'breathe' and replicate without an oxygen-rich environment crucial for other kinds of cells," Dr. Sadek said.
In addition to being successfully used for bone-marrow transplantation for years, bone-marrow cells are used in hundreds of studies for heart regeneration, he said.
"The findings of this paper highlight important characteristics of bone-marrow stem cells that make them more likely to survive in the low-oxygen environments present, for example, after a heart attack," Dr. Sadek said. "These findings may also be exploited to enrich bone-marrow stem and progenitor cells by selecting cells based on their metabolic properties."
Other UT Southwestern researchers who contributed to the study include lead authors Dr. Tugba Simsek, research assistant, and Fatih Kocabas, student research assistant; Dr. Junke Zheng; postdoctoral researcher; Dr. Ralph DeBerardinis, assistant professor of pediatrics; Ahmed Mahmoud, student research assistant; Dr. Eric Olson, chairman of molecular biology; Dr. Jay Schneider, assistant professor of internal medicine; and Dr. Chengcheng Zhang, assistant professor of physiology and developmental biology.
The research was supported by the American Heart Association, the Donald W. Reynolds Foundation and the Welch Foundation.
Visit http://www.utsouthwestern.org/transplants to learn more about UT Southwestern's clinical services in transplants, including bone marrow
This news release is available on our World Wide Web home page at http://www.utsouthwestern.edu/home/news/index.html
To automatically receive news releases from UT Southwestern via e-mail, subscribe at http://www.utsouthwestern.edu/receivenews
Katherine Morales | EurekAlert!
MicroRNA helps cancer evade immune system
19.09.2017 | Salk Institute
Ruby: Jacobs University scientists are collaborating in the development of a new type of chocolate
18.09.2017 | Jacobs University Bremen gGmbH
Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!
When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...
For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.
Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...
MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.
MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems...
Pathogenic bacteria are becoming resistant to common antibiotics to an ever increasing degree. One of the most difficult germs is Pseudomonas aeruginosa, a...
Scientists from the MPI for Chemical Energy Conversion report in the first issue of the new journal JOULE.
Cell Press has just released the first issue of Joule, a new journal dedicated to sustainable energy research. In this issue James Birrell, Olaf Rüdiger,...
19.09.2017 | Event News
12.09.2017 | Event News
06.09.2017 | Event News
19.09.2017 | Event News
19.09.2017 | Physics and Astronomy
19.09.2017 | Power and Electrical Engineering