Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers find changes to protein SirT1

28.01.2014
May prevent excess metabolic stress associated with obesity, diabetes and aging

Researchers find changes to protein SirT1 can prevent excess metabolic stress associated with obesity, diabetes and aging.

Studies have suggested that the protein SirT1 may be protective in metabolic diseases and the effects of aging, and diminished SirT1 activity has been reported in various disease models including diabetes and metabolic syndrome. Maintaining a normal level of this protein may be effective in preventing obesity- and age-related diseases.

Metabolic stress caused by obesity, diabetes and aging increases a small molecule, glutathione that reacts with SirT1, inhibiting its activity. In a recent paper published online in the Journal of Biological Chemistry, Boston University School of Medicine (BUSM) researchers have demonstrated that by changing three of the amino acids on SirT1 they could produce a "super-sirt" which functioned normally despite the metabolic stress.

"In the process of preventing the effects of the stress occasioned by metabolic excess typical of obesity, diabetes and aging, the enzyme function of SirT1 can be destroyed by the very metabolic stress it is trying to overcome," says Richard Cohen, MD, professor of medicine and director of the section of vascular biology at BUSM.

"This study establishes that stresses associated with excess metabolism can be circumvented by changing the protein, or by preventing the glutathione reaction with the protein."

Gina DiGravio | EurekAlert!
Further information:
http://www.bmc.org

Further reports about: BUSM SIRT1 Vascular Biology amino acid metabolic stress protein SirT1

More articles from Life Sciences:

nachricht Saving Seeds the Right Way Can Save the World's Plants
31.07.2014 | National Institute for Mathematical and Biological Synthesis (NIMBioS)

nachricht Marine pest provides advances in maritime anti-fouling and biomedicine
31.07.2014 | Clemson University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Anzeige

Anzeige

Event News

Counting down to FEBS-EMBO 2014 in Paris, France

29.07.2014 | Event News

9th European Wood-Based Panel Symposium 2014 – meeting point for the wood-based material branch

24.07.2014 | Event News

“Lens on Life” - Artists and Scientists Explore Cell Divison

08.07.2014 | Event News

 
Latest News

Mapping the optimal route between 2 quantum states

31.07.2014 | Physics and Astronomy

Monoamine oxidase A: biomarker for postpartum depression

31.07.2014 | Health and Medicine

Saving Seeds the Right Way Can Save the World's Plants

31.07.2014 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>