Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers find changes to protein SirT1

28.01.2014
May prevent excess metabolic stress associated with obesity, diabetes and aging

Researchers find changes to protein SirT1 can prevent excess metabolic stress associated with obesity, diabetes and aging.

Studies have suggested that the protein SirT1 may be protective in metabolic diseases and the effects of aging, and diminished SirT1 activity has been reported in various disease models including diabetes and metabolic syndrome. Maintaining a normal level of this protein may be effective in preventing obesity- and age-related diseases.

Metabolic stress caused by obesity, diabetes and aging increases a small molecule, glutathione that reacts with SirT1, inhibiting its activity. In a recent paper published online in the Journal of Biological Chemistry, Boston University School of Medicine (BUSM) researchers have demonstrated that by changing three of the amino acids on SirT1 they could produce a "super-sirt" which functioned normally despite the metabolic stress.

"In the process of preventing the effects of the stress occasioned by metabolic excess typical of obesity, diabetes and aging, the enzyme function of SirT1 can be destroyed by the very metabolic stress it is trying to overcome," says Richard Cohen, MD, professor of medicine and director of the section of vascular biology at BUSM.

"This study establishes that stresses associated with excess metabolism can be circumvented by changing the protein, or by preventing the glutathione reaction with the protein."

Gina DiGravio | EurekAlert!
Further information:
http://www.bmc.org

Further reports about: BUSM SIRT1 Vascular Biology amino acid metabolic stress protein SirT1

More articles from Life Sciences:

nachricht From Termite Fumigant to Molecular Coupling
01.09.2014 | Angewandte Chemie International Edition

nachricht Tilapia fish: Ready for mating at the right time
01.09.2014 | Max Planck Institute for Chemical Ecology, Jena

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Anzeige

Anzeige

Event News

IT security in the digital society

27.08.2014 | Event News

Understanding the brain—neuroscientists meet in Göttingen

27.08.2014 | Event News

MEDICA EDUCATION CONFERENCE: Bessere Behandlung dank Biomarker

21.08.2014 | Event News

 
Latest News

Endangered Siamese Crocs Released in Wild

01.09.2014 | Ecology, The Environment and Conservation

Doing More with Less: New Technique Uses Fraction of Measurements to Efficiently Find Quantum Wave Functions

01.09.2014 | Physics and Astronomy

Simpler Process to Grow Germanium Nanowires Could Improve Lithium-Ion Batteries

01.09.2014 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>