Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers find missing genes may separate coach potato from active cousin

06.09.2011
You may think your lack of resolve to get off the couch to exercise is because you're lazy, but McMaster University researchers have discovered it may be you are missing key genes.

The researchers made their unexpected finding while working with healthy, specially-bred mice, some of which had two genes in muscle essential for exercise removed. The genes control the protein AMP-activated protein kinase (AMPK), an enzyme that is switched on when you exercise.

"Mice love to run," said Gregory Steinberg, associate professor of medicine in the Michael G. DeGroote School of Medicine and Canada Research Chair in Metabolism and Obesity.

"While the normal mice could run for miles, those without the genes in their muscle could only run the same distance as down the hall and back. It was remarkable. The mice looked identical to their brothers or sisters but within seconds we knew which ones had the genes and which one didn't."

The researchers found the mice without the muscle AMPK genes had lower levels of mitochondria and an impaired ability for their muscles to take up glucose while they exercise.

"When you exercise you get more mitochondria growing in your muscle. If you don't exercise, the number of mitochondria goes down. By removing these genes we identified the key regulator of the mitochondria is the enzyme AMPK," said Steinberg.

Thousands of scientists around the world are working on AMPK but the McMaster team is the first to demonstrate its essential role in exercise. Their research appears in the current issue of the Proceedings of the National Academy of Sciences.

Steinberg said the findings are important for individuals who find it difficult to exercise, such as the obese, asthmatics and people in wheelchairs. Their inability to exercise may lead to other complications such as diabetes and heart disease.

The study, he thinks, has a message for couch potatoes. "As we remove activity from our lives due to emerging technology, the base level of fitness in the population is going down and that is reducing the mitochondria in people's muscles. This in turn makes it so much harder for people to start exercising."

Steinberg himself runs or bikes to work. "It is the only way that I can manage to make sure I stay fit."

Note: A photo of a mouse on a couch can be found at http://fhs.mcmaster.ca/media/media_20110901.html

For more information or interviews, please contact:
Veronica McGuire
Media Relations Coordinator
Faculty of Health Sciences
McMaster University
905-525-9140, ext. 22169
vmcguir@mcmaster.ca

Veronica McGuire | EurekAlert!
Further information:
http://www.mcmaster.ca

Further reports about: AMP-activated protein kinase AMPK couch potatoes mitochondria

More articles from Life Sciences:

nachricht A novel socio-ecological approach helps identifying suitable wolf habitats
17.02.2017 | Universität Zürich

nachricht New, ultra-flexible probes form reliable, scar-free integration with the brain
16.02.2017 | University of Texas at Austin

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Switched-on DNA

20.02.2017 | Materials Sciences

Second cause of hidden hearing loss identified

20.02.2017 | Health and Medicine

Prospect for more effective treatment of nerve pain

20.02.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>