Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers discover protein that could help prevent the spread of cancer

05.05.2011
A protein capable of halting the spread of breast cancer cells could lead to a therapy for preventing or limiting the spread of the disease.

"Cancer researchers want to design new therapeutic strategies in which the metastasis or spreading stage of cancer can be blocked," explains Andrew Craig, lead researcher and a professor in Queen's Department of Biochemistry and Cancer Research Institute. "Patients stand a much better chance of survival if the primary tumor is the only tumor that needs to be treated."

The regulatory protein identified by Dr Craig's team inhibits the spread of cancer cells by removing and breaking down an invasive enzyme on the surface of cancer cells. If it remains unchecked, this enzyme degrades and modifies surrounding tissues, facilitating the spread of cancer through the body.

Dr. Craig hopes that his team's findings may help develop more targeted therapies that have a specific inhibitory function on this enzyme that is implicated in certain metastatic cancers.

Traditional therapies that have been used to counteract the invasive nature of this particular enzyme also destroy other enzymes that are important for the body's normal physiological function.

The researchers examined a network of proteins that are responsible for controlling the shape of cancer cells. They focused specifically on parts of the cell that protrude into surrounding body tissues, allowing the cancer cell to degrade surrounding tissue barriers.

Normal cells also produce similar protrusions as part of a healthy physiological process that allows cells to move through body tissues during an immune response.

During the spread of cancer these normally healthy mechanisms are coopted by cancer cells, allowing the cancer to break through tissue boundaries and colonize distant tissues. This process of cancer spread is known as metastasis and is frequently the cause of cancer-related deaths.

This research, which was funded by the Canadian Breast Cancer Foundation, will be featured on the cover of the May issue of the Journal of Cell Science, one of the most prestigious international cell biology journals.

Christina Archibald | EurekAlert!
Further information:
http://www.queensu.ca

More articles from Life Sciences:

nachricht Cells communicate in a dynamic code
19.02.2018 | California Institute of Technology

nachricht Studying mitosis' structure to understand the inside of cancer cells
19.02.2018 | Biophysical Society

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: In best circles: First integrated circuit from self-assembled polymer

For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.

In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

Im Focus: Interference as a new method for cooling quantum devices

Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters

Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Contacting the molecular world through graphene nanoribbons

19.02.2018 | Materials Sciences

When Proteins Shake Hands

19.02.2018 | Materials Sciences

Cells communicate in a dynamic code

19.02.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>