Scientists at the Helmholtz Zentrum München have elucidated a mechanism that is responsible for the development of adrenal gland tumors. They discovered that the BMP7 protein plays a key role in this process and that it could be a possible target for future treatments. The results have been published in the journal ‘Oncotarget’.
Specifically, the team headed by Dr. Natalia Pellegata of the Institute of Pathology (PATH) at the Helmholtz Zentrum München conducted a study on pheochromocytomas (PCCs). Pheochromocytomas are active adrenal gland tumors, the majority of which are benign.
Ines Leinhäuser and Dr. Natalia Pellegata
Source: Helmholtz Zentrum München (HMGU)
However, if they become malignant and spread to other tissues, the prognosis for these patients is poor. This is mainly due to the fact that currently the only treatment available for PCCs is their surgical removal. In order to develop new treatment therapies, the researchers initially examined the molecular mechanisms behind this disease.
Particularly high incidence of protein BMP7 in PCC samples
“Our initial data from patient samples shows that the growth factor BMP7 is found frequently overexpressed in samples from PCC patients,” recalls first author Ines Leinhäuser. In further studies, the Helmholtz scientists examined the possible consequences of a higher level of this protein. In various functional tests, they were able to prove that elevated levels of BMP7 promote PCC cell division and cell migration. Conversely, if the protein is targeted for knockdown, this results in less invasive cells.
Active substances that target the BMP7 signaling pathway kill off tumor cells
The researchers identified a particular signaling pathway as the cause of this effect on the cells. “The PI3K/mTOR pathway is activated by the BMP7 protein and conveys signals for the cells to divide as well as to migrate,” explains team leader Pellegata. In order to verify this mechanism and to test potential future treatments, the team used two molecules.
One molecule inhibits the signal transmission of BMP7; the other blocks the PI3K/mTOR downstream signaling pathway. “In an animal model of PCC we were able to show that treating the tumors with substances inhibiting BMP signaling can lead to an increase in apoptosis*,” Pellegata adds. Although further tests will be needed in order to confirm these results, the cancer researchers hope that they have found a new approach to future treatments.
* Apoptosis is the process of programmed cell death. It serves to remove degenerate or potentially harmful cells. Apoptosis also occurs during development, for example during the regulation of cell numbers, and thus influences tissue size or the regression of skin webbing.
Leinhaeuser, I. et al. (2015). Oncogenic features of the bone morphogenic protein 7 (BMP7) in pheochromocytoma, Oncotarget
As German Research Center for Environmental Health, Helmholtz Zentrum München pursues the goal of developing personalized medical approaches for the prevention and therapy of major common diseases such as diabetes mellitus and lung diseases. To achieve this, it investigates the interaction of genetics, environmental factors and lifestyle. The Helmholtz Zentrum München has about 2,300 staff members and is headquartered in Neuherberg in the north of Munich. Helmholtz Zentrum München is a member of the Helmholtz Association, a community of 18 scientific-technical and medical-biological research centers with a total of about 37,000 staff members.
The Institute of Pathology (PATH) contributes to the identification and characterization of molecular mechanisms and pathways, which are relevant for disease development and progression. We endeavor to understand the interplay between environment and genetic, and to identify novel targets for therapeutic intervention.
Contact for the media:
Department of Communication, Helmholtz Zentrum München – German Research Center for Environmental Health (GmbH), Ingolstädter Landstr. 1, 85764 Neuherberg - Phone: +49 89 3187 2238 - Fax: +49 89 3187 3324 – E-mail: email@example.com
Scientific contact at Helmholtz Zentrum München:
Dr. Natalia Pellegata, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Institute of Pathology, Ingolstädter Landstr. 1, 85764 Neuherberg - Phone +49 89 3187 2633 - E-mail: firstname.lastname@example.org
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path=4912&path=12027 - Link to the publication
http://www.helmholtz-muenchen.de/en/news/press-releases/2015/index.html - Press releases Helmholtz Zentrum München
http://www.helmholtz-muenchen.de/en/path/index.html - Institute of Pathology
Kommunikation | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
Closing the carbon loop
08.12.2016 | University of Pittsburgh
Newly discovered bacteria-binding protein in the intestine
08.12.2016 | University of Gothenburg
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
08.12.2016 | Life Sciences
08.12.2016 | Physics and Astronomy
08.12.2016 | Materials Sciences