Their work opens a new chapter in the understanding of protein synthesis under stress conditions, which are the conditions bacteria usually are faced with, both in humans and otherwise in nature, and could pave the way for the design of novel, new antibiotics that would help to overcome serious public health problems, the researchers believe.
In the last 50 years, the biological machinery responsible for protein synthesis has been extensively studied, in particular in the gastric bacteria Escherichia coli (E.coli). The machinery of protein synthesis operates primarily through ribosomes -- small particle present in large numbers in every living cell whose function is to convert genetic information into protein molecules -- and messenger RNAs (mRNAs), which transfer the genetic information from the genome to the ribosomes and thereby direct the synthesis of cell proteins.
In an article in a recent issue of the journal Cell, Prof Hanna Engelberg-Kulka of the Institute for Medical Research Israel Canada (IMRIC) at the Hebrew University–Hadassah Medical School and her students describe the discovery of a novel molecular machinery for protein synthesis that is generated and operates under stress conditions in E.coli.. The work described in the Cell article was done in collaboration with the laboratory of Prof. Isabella Moll of the University of Vienna.
Their study represents is a breakthrough since it shows, for the first time, that under stress conditions, such as nutrient starvation and antibiotics, the synthesis of a specific toxic protein is induced that causes a change in the protein-synthesizing machinery of the bacteria. This toxic protein cleaves parts of the ribosome and the mRNAs, thereby preventing the usual interaction between these two components.
As a result, an alternative protein-synthesizing machinery is generated. It includes a specialized sub-class of ribosomes, called “stress ribosomes,” which is involved in the selective synthesis of proteins that are directed by the sliced mRNAs, and is responsible for bacterial cell death.
Practically speaking, the discovery of a “stress-induced protein synthesizing machinery” may offer a new way for the design of improved, novel antibiotics that would effectively utilize the stress-inducing mechanism process in order to more efficiently cripple pathogenic bacteria.
Jerry Barach | Hebrew University of Jerusalem
Researchers identify potentially druggable mutant p53 proteins that promote cancer growth
09.12.2016 | Cold Spring Harbor Laboratory
Plant-based substance boosts eyelash growth
09.12.2016 | Fraunhofer-Institut für Angewandte Polymerforschung IAP
Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.
Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
09.12.2016 | Life Sciences
09.12.2016 | Ecology, The Environment and Conservation
09.12.2016 | Health and Medicine