Their work opens a new chapter in the understanding of protein synthesis under stress conditions, which are the conditions bacteria usually are faced with, both in humans and otherwise in nature, and could pave the way for the design of novel, new antibiotics that would help to overcome serious public health problems, the researchers believe.
In the last 50 years, the biological machinery responsible for protein synthesis has been extensively studied, in particular in the gastric bacteria Escherichia coli (E.coli). The machinery of protein synthesis operates primarily through ribosomes -- small particle present in large numbers in every living cell whose function is to convert genetic information into protein molecules -- and messenger RNAs (mRNAs), which transfer the genetic information from the genome to the ribosomes and thereby direct the synthesis of cell proteins.
In an article in a recent issue of the journal Cell, Prof Hanna Engelberg-Kulka of the Institute for Medical Research Israel Canada (IMRIC) at the Hebrew University–Hadassah Medical School and her students describe the discovery of a novel molecular machinery for protein synthesis that is generated and operates under stress conditions in E.coli.. The work described in the Cell article was done in collaboration with the laboratory of Prof. Isabella Moll of the University of Vienna.
Their study represents is a breakthrough since it shows, for the first time, that under stress conditions, such as nutrient starvation and antibiotics, the synthesis of a specific toxic protein is induced that causes a change in the protein-synthesizing machinery of the bacteria. This toxic protein cleaves parts of the ribosome and the mRNAs, thereby preventing the usual interaction between these two components.
As a result, an alternative protein-synthesizing machinery is generated. It includes a specialized sub-class of ribosomes, called “stress ribosomes,” which is involved in the selective synthesis of proteins that are directed by the sliced mRNAs, and is responsible for bacterial cell death.
Practically speaking, the discovery of a “stress-induced protein synthesizing machinery” may offer a new way for the design of improved, novel antibiotics that would effectively utilize the stress-inducing mechanism process in order to more efficiently cripple pathogenic bacteria.
Jerry Barach | Hebrew University of Jerusalem
Newly designed molecule binds nitrogen
23.02.2018 | Julius-Maximilians-Universität Würzburg
Atomic Design by Water
23.02.2018 | Max-Planck-Institut für Eisenforschung GmbH
A newly developed laser technology has enabled physicists in the Laboratory for Attosecond Physics (jointly run by LMU Munich and the Max Planck Institute of Quantum Optics) to generate attosecond bursts of high-energy photons of unprecedented intensity. This has made it possible to observe the interaction of multiple photons in a single such pulse with electrons in the inner orbital shell of an atom.
In order to observe the ultrafast electron motion in the inner shells of atoms with short light pulses, the pulses must not only be ultrashort, but very...
A group of researchers led by Andrea Cavalleri at the Max Planck Institute for Structure and Dynamics of Matter (MPSD) in Hamburg has demonstrated a new method enabling precise measurements of the interatomic forces that hold crystalline solids together. The paper Probing the Interatomic Potential of Solids by Strong-Field Nonlinear Phononics, published online in Nature, explains how a terahertz-frequency laser pulse can drive very large deformations of the crystal.
By measuring the highly unusual atomic trajectories under extreme electromagnetic transients, the MPSD group could reconstruct how rigid the atomic bonds are...
Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...
For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.
In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
15.02.2018 | Event News
13.02.2018 | Event News
12.02.2018 | Event News
23.02.2018 | Physics and Astronomy
23.02.2018 | Health and Medicine
23.02.2018 | Physics and Astronomy