The discovery, reported in the article “Arpc 1b, a centrosomal protein, is both an activator and substrate of Aurora A,” furthers the science world’s understanding of what happens during the fundamental process of mitosis, when cells divide. The article was published in the current issue of The Journal of Cell Biology.
“This represents a crucial moment when the division of genetic material is still equally distributed. An even exchange is critical for stable genetic changes,” said Rakesh Kumar, Ph.D., chair of the GW Department of Biochemistry and Molecular Biology. In mitosis, cells begin to divide and genetic material coalesces around separate poles to form new cells. If all goes well that material is evenly distributed and two genetically identical “daughter cells” are formed. If something goes awry, however, it can result in the cascading production of aberrant cells with unequal and less ordered DNA and possibly cancer.
Lead authors Poonam R. Molli, Ph.D., ex-postdoctoral fellow, and Da-Qiang Li, M.D., assistant research professor, from GW’s Department of Biochemistry and Molecular Biology, have identified a protein, Arpc 1b, that serves as both an activator as well as a substrate for Aurora A, an enzyme which plays a central role in cellular reproduction in normal cells but is overexpressed in several cancers. This represents perhaps the earliest step in mitosis and serves as the missing link regarding the role this protein plays in starting the cell cycle and what keeps the process in balance. The authors discovered that Arpc1b also exists as a stand alone protein and believe that it might also play an independent role outside its established contribution to actin machinery.
More than just an observation of how cells divide, this discovery also offers a potential target for pharmaceutical therapy. Both Aurora A and Arpc1b are over-expressed in breast cancers. Pharmaceutical inhibitors targeting Aurora A are currently available and thus, could be combined with other future targeting strategies. The researchers discovered that an over-expression of Arpc1b promotes tumorigenic properties of breast cancer cells. Scientists believe that if they can someday find a means of suppressing the activity of Arpc 1b in cancer cell, the balance could be restored to this dynamic yet tightly regulated biological event.
“This discovery is the result of persistence and the commitment to scientific breakthrough,” said Dr. Kumar. “Asking a question and staying involved until you find the answer to close the loop is critical in scientific discovery.” In this case the earliest piece of data used here was obtained in 2001.
To learn more about this research, view The Journal of Cell Biology article: http://jcb.rupress.org/content/early/2010/06/30/jcb.200908050.full
Anne Banner | Newswise Science News
The big clean up after stress
25.05.2018 | Julius-Maximilians-Universität Würzburg
Complementing conventional antibiotics
24.05.2018 | Goethe-Universität Frankfurt am Main
A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.
The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
24.05.2018 | Ecology, The Environment and Conservation
24.05.2018 | Medical Engineering
24.05.2018 | Physics and Astronomy