Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Researchers discover gene that helps control the production of stomach acid

University of Cincinnati (UC) researchers have discovered a gene that helps control the secretion of acid in the stomach—information that could one day aid scientists in creating more efficient treatment options for conditions such as acid reflux or peptic ulcers.

This data is published in the Nov. 3 edition of the Proceedings of the National Academy of Sciences (PNAS).

UC professor Manoocher Soleimani, MD, and colleagues found that when transporter Slc26a9—the gene responsible for the production of chloride in the stomach—is eliminated from the mouse model's system, acid secretion in the stomach stops.

Gastric acid, comprised mainly of hydrochloric acid (HCL), is the main secretion in the stomach and helps the body to break down and digest food.

"Investigators were already aware of the gene that caused hydrogen to secrete in the stomach, but the gene that caused chloride to secrete has remained an unknown," Soleimani says. "When we knocked out—or eliminated—this specific transporter in mouse models, acid secretion in the stomach completely halted."

"The hydrogen and chloride genes must work together in order for the stomach to produce acid and function normally."

Soleimani, director of UC's nephrology division and principal investigator of the study, hopes that this data can help researchers create more therapies for people who overproduce stomach acid.

"A very large number of people have acid reflux—caused by regurgitation of stomach acid into the esophagus—or peptic ulcers—caused by the passing of excess stomach acid into the small intestine," Soleimani says. "This occurs because of overproduction of acid in the stomach, and current medications that help control this condition cause undesirable side effects."

He adds that long-term use of these kinds of drugs could cause damage to the lining of the stomach, among other problems.

"With this information, we hope to one day be able to administer gene therapies to patients and avoid this painful and damaging problem altogether," he says.

Katie Pence | EurekAlert!
Further information:

More articles from Life Sciences:

nachricht First time-lapse footage of cell activity during limb regeneration
25.10.2016 | eLife

nachricht Phenotype at the push of a button
25.10.2016 | Institut für Pflanzenbiochemie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Light-driven atomic rotations excite magnetic waves

Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion

Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Enormous dome in central Andes driven by huge magma body beneath it

25.10.2016 | Earth Sciences

First time-lapse footage of cell activity during limb regeneration

25.10.2016 | Life Sciences

Deep down fracking wells, microbial communities thrive

25.10.2016 | Earth Sciences

More VideoLinks >>>