Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers Create Promising Vaccine for Staph Infection

26.10.2011
Boise State University researchers have created a new vaccine that shows high promise in preventing Staphylococcus aureus, a bacterium that can cause a range of illnesses such as skin infections and pneumonia.

Each year, nearly 500,000 Americans are admitted to hospitals for staph infections. Research shows that more than 50 percent of those are from methicillin-resistant S. aureus, or MRSA, which is resistant to current antibiotics.

Boise State biology scientists created a vaccine that uses a cholera toxin molecule called A2/B chimera, which also contains an iron-regulated surface determinant from S. aureus, that was given to mice through the nose. The researchers believed that these stable chimeric molecules with unique binding properties would provide immunity to staph infections. The results supported this theory and showed that the new vaccine could induce significant immunity to staph in mice when delivered through the nose.

The results appear online in the journal Clinical and Vaccine Immunology.

“We knew that a successful vaccine against staph would have to contain a combination of antigens,” study co-author Juliette Tinker, assistant professor of biological sciences at Boise State. “Staph is a very complex bacteria that has a lot of proteins on the surface that change frequently, so we picked one that seemed to be present in many of the strains of staph. We knew only incorporating one or two proteins into a vaccine wasn’t enough, we needed many.”

Tinker and her research team studied the immune response in 24 mice that were given the vaccine they created and measured how many antibodies the mice produced against staph over 45 days. The results showed the mice had a significant number of antibodies against staph, although a booster dose was needed after the 10th day.

Matt Pene | Newswise Science News
Further information:
http://www.boisestate.edu

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

3rd Symposium on Driving Simulation

23.10.2017 | Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

 
Latest News

50th Anniversary at JULABO GmbH

23.10.2017 | Press release

Taming 'wild' electrons in graphene

23.10.2017 | Physics and Astronomy

Mountain glaciers shrinking across the West

23.10.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>