Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers boost insect aggression by altering brain metabolism

06.08.2014

Scientists report they can crank up insect aggression simply by interfering with a basic metabolic pathway in the insect brain. Their study, of fruit flies and honey bees, shows a direct, causal link between brain metabolism (how the brain generates the energy it needs to function) and aggression. The team reports its findings in the Proceedings of the National Academy of Sciences.

The new research follows up on previous work from the laboratory of University of Illinois entomology professor and Institute for Genomic Biology director Gene Robinson, who also led the new analysis. When he and his colleagues looked at brain gene activity in honey bees after they had faced down an intruder, the team found that some metabolic genes were suppressed. These genes play a key role in the most efficient type of energy generation in cells, a process called oxidative phosphorylation.

Honey Bee Aggression

Some insects are more aggressive than others in response to an intruder. Watch a video of honey bees responding to an intruder bee. (See link in news release.)

Credit: Jon Sullivan

"It was a counterintuitive finding because these genes were down-regulated," Robinson said. "You tend to think of aggression as requiring more energy, not less."

In the new study, postdoctoral researcher Clare Rittschof used drugs to suppress key steps in oxidative phosphorylation in the bee brains. She saw that aggression increased in the drugged bees in a dose-responsive manner, Robinson said. But the drugs had no effect on chronically stressed bees – they were not able to increase their aggression in response to an intruder. (Watch a video of honey bees responding to an intruder.)

... more about:
»drugs »flies »genes »insect »intruder »metabolism »phosphorylation »skin »steps

"Something about chronic stress changed their response to the drug, which is a fascinating finding in and of itself," Robinson said. "We want to know just how this experience gets under their skin to affect their brain."

In separate experiments, postdoctoral researcher Hongmei Li-Byarlay and undergraduate student Jonathan Massey found that reduced oxidative phosphorylation in fruit flies also increased aggression. Using advanced fly genetics, the team found this effect only when oxidative phosphorylation was reduced in neurons, but not in neighboring cells known as glia. This result, too, was surprising, since "glia are metabolically very active, and are the energy storehouses of the brain," Robinson said.

The findings offer insight into the immediate and longer-term changes that occur in response to threats, Robinson said.

"When an animal faces a threat, it has an immediate aggressive response, within seconds," Robinson said. But changes in brain metabolism take much longer and cannot account for this immediate response, he said. Such changes likely make individuals more vigilant to subsequent threats.

"This makes good sense in an ecological sense," Robinson said, "because threats often come in bunches."

The fact that the researchers observed these effects in two species that diverged 300 million years ago makes the findings even more compelling, Robinson said.

"Because fruit flies and honey bees are separated by 300 million years of evolution, this is a very robust and well-conserved mechanism," he said.

###

The National Science Foundation supported this work.

Editor's notes: To reach Gene Robinson, call 217-265-0309; email generobi@illinois.edu.

The paper, "Socially responsive effects of brain oxidative metabolism on aggression," is available online or from the U. of I. News Bureau.

Diana Yates | University of Illinois at Urbana-Champaign
Further information:
http://illinois.edu/

Further reports about: drugs flies genes insect intruder metabolism phosphorylation skin steps

More articles from Life Sciences:

nachricht A new potential biomarker for cancer imaging
05.02.2016 | Universiti Putra Malaysia (UPM)

nachricht NIH researchers identify striking genomic signature shared by 5 types of cancer
05.02.2016 | NIH/National Human Genome Research Institute

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Automated driving: Steering without limits

OmniSteer project to increase automobiles’ urban maneuverability begins with a € 3.4 million budget

Automobiles increase the mobility of their users. However, their maneuverability is pushed to the limit by cramped inner city conditions. Those who need to...

Im Focus: Microscopy: Nine at one blow

Advance in biomedical imaging: The University of Würzburg's Biocenter has enhanced fluorescence microscopy to label and visualise up to nine different cell structures simultaneously.

Fluorescence microscopy allows researchers to visualise biomolecules in cells. They label the molecules using fluorescent probes, excite them with light and...

Im Focus: NASA's ICESat-2 equipped with unique 3-D manufactured part

NASA's follow-on to the successful ICESat mission will employ a never-before-flown technique for determining the topography of ice sheets and the thickness of sea ice, but that won't be the only first for this mission.

Slated for launch in 2018, NASA's Ice, Cloud and land Elevation Satellite-2 (ICESat-2) also will carry a 3-D printed part made of polyetherketoneketone (PEKK),...

Im Focus: Sinking islands: Does the rise of sea level endanger the Takuu Atoll in the Pacific?

In the last decades, sea level has been rising continuously – about 3.3 mm per year. For reef islands such as the Maldives or the Marshall Islands a sinister picture is being painted evoking the demise of the island states and their cultures. Are the effects of sea-level rise already noticeable on reef islands? Scientists from the ZMT have now answered this question for the Takuu Atoll, a group of Pacific islands, located northeast of Papua New Guinea.

In the last decades, sea level has been rising continuously – about 3.3 mm per year. For reef islands such as the Maldives or the Marshall Islands a sinister...

Im Focus: Energy-saving minicomputers for the ‘Internet of Things’

The ‘Internet of Things’ is growing rapidly. Mobile phones, washing machines and the milk bottle in the fridge: the idea is that minicomputers connected to these will be able to process information, receive and send data. This requires electrical power. Transistors that are capable of switching information with a single electron use far less power than field effect transistors that are commonly used in computers. However, these innovative electronic switches do not yet work at room temperature. Scientists working on the new EU research project ‘Ions4Set’ intend to change this. The program will be launched on February 1. It is coordinated by the Helmholtz-Zentrum Dresden-Rossendorf (HZDR).

“Billions of tiny computers will in future communicate with each other via the Internet or locally. Yet power consumption currently remains a great obstacle”,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

AKL’16: Experience Laser Technology Live in Europe´s Largest Laser Application Center!

02.02.2016 | Event News

From intelligent knee braces to anti-theft backpacks

26.01.2016 | Event News

DATE 2016 Highlighting Automotive and Secure Systems

26.01.2016 | Event News

 
Latest News

A new potential biomarker for cancer imaging

05.02.2016 | Life Sciences

Graphene is strong, but is it tough?

05.02.2016 | Materials Sciences

Tiniest Particles Shrink Before Exploding When Hit With SLAC's X-ray Laser

05.02.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>