This breakthrough is expected to lead to better medication, in particular better treatments for leukemia, skin cancer, and infections caused by multi-resistant bacteria. Thanks to this new knowledge, it is hoped that future medical therapies will be more effective and have far fewer side effects.
The first trials on patients are expected to take place over the next two years and the first finished products should be entering the market ten years from now.
The research has focused on peptides which target and lethally harm cancer cells. Cytotoxic peptides are short chains of amino acids that are able to penetrate and damage the lipid membrane surrounding individual cancer cells. By manipulating this response, researchers hope to cause cancer cells to die off and leave all other cells unharmed.
− Our research has shown that the mechanism by which these life-saving peptides trigger cell-death is similar to that utilized by peptides which are the culprit of certain neurodegenerative diseases, explains Professor Paavo Kinnunen, whose research team at the Department of Biomedical Engineering has made the breakthrough. The mechanism is similar, yet the effects are polar opposites – either beneficial or lethal. Hence, the research results reached by Kinnunen and his team may affect not only the treatment of cancer but also the current understanding of neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases and their treatment.
Professor Kinnunen and his team have worked on cytotoxic peptides for a number of years. Interest in the topic is shared by research groups in many other universities, and other researchers have been able to confirm results reached by Kinnunen and his team.For further information, please contact:
tel. +358 50 540 4600
Aalto University is a new multidisciplinary science and art community in the fields of science, economics, and art and design. The new University is founded on Finnish strengths, and its goal is to develop as a unique entity to become one of the world's top universities. Aalto University's cornerstones are its strengths in education and research. At the new University, there are 20,000 basic degree and graduate students as well as a staff of 4,500 of which 340 are professors.Communications
Terhi Arvela | Aalto University
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Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
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Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
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Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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