Dr. Esther Guzm¨¢n, assistant research professor at Harbor Branch Oceanographic Institute at Florida Atlantic University, has received a $375,000 grant from the Bankhead Coley Florida Biomedical Research Program for a research project to identify bioactive marine natural products that inhibit inflammation as potential novel chemo-preventatives of pancreatic cancer.
Pancreatic cancer is the fifth most lethal cancer in the United States due to its strong metastatic potential and its delayed detection, as most patients remain asymptomatic until the cancer metastasizes. Ninety-five percent of patients diagnosed with the disease die within five years of diagnosis.
Guzm¨¢n, an expert in immunology and cancer research, and her colleagues are looking to the oceans as a rich source of bioactive natural products. The uniqueness, chemical diversity and complexity of marine natural products represent an unexploited supply of potential new drugs, lead compounds for medicinal chemistry and biological probes to allow for a better understanding of diseases including pancreatic cancer.
¡°Esther exemplifies excellence as a young scientist at Harbor Branch,¡± said Dr. Amy Wright, professor and director of the Center for Marine Biomedical and Biotechnology Research at Harbor Branch, where Guzm¨¢n works. ¡°Receiving this highly competitive award is further evidence of the value of her cutting-edge research and her many skills and talents.¡±
The Center for Marine Biomedical and Biotechnology Research at Harbor Branch has developed a unique screening library of secondary metabolites isolated from deep water marine invertebrates that hold promise in preventing both the formation of new pancreatic tumors and the metastasis of existing tumors which are facilitated by chronic inflammation. Guzm¨¢n will utilize this library to identify novel inhibitors of inflammation expected to be found among secondary metabolites from marine organisms. Three important signaling molecules in inflammation have been validated as chemo-preventative drug targets in pancreatic cancer: the nuclear factor ¦ÊB (NF¦ÊB), interleukin 8 (IL-8/CXCL8) and the signal transducer and activator of transcription 3 (STAT3). These researchers will focus on these molecules, which are important inflammatory regulators and have been implicated with the aggressiveness of pancreatic cancer. Once they have confirmed the activity in pancreatic cancer cells, the most active samples will be further validated by determining if they help stop the proliferation of pancreatic cancer cells or promote their death. The data obtained from this project will be used to secure funding to perform the steps necessary to bring compounds discovered through this research closer to the patient.
According to an article titled ¡°Inflammation and the Development of Pancreatic Cancer¡± published in the Journal of Surgical Oncology (Farrow, B. and B.M. Evers ¨C 2002), chronic pancreatitis is a progressive, destructive inflammatory process that ends in total destruction of the pancreas. Patients who suffer from hereditary pancreatitis have a 53 times higher risk of developing pancreatic cancer than unaffected individuals; patients with sporadic chronic pancreatitis have a 17 times higher risk.
¡°While the exact reason why pancreatitis patients have an increased risk of developing pancreatic cancer is not understood, inflammation is thought to create a microenvironment that facilitates the initiation and/or growth of pancreatic cancer cells,¡± said Guzm¨¢n.
Every seventeen minutes someone is diagnosed with pancreatic cancer. According to the American Cancer Society, the risk of developing pancreatic cancer increases with age. Almost 90% of patients are older than 55 and the average age at the time the cancer is found is 72.
¡°Current treatments for pancreatic cancer remain only moderately effective, as attested by the low survival rate,¡± said Guzm¨¢n. ¡°Furthermore, this type of cancer is highly resistant to all current chemotherapies, and novel drugs and new therapies are urgently needed to treat this disease.¡±
Harbor Branch Oceanographic Institute at Florida Atlantic University is a research institute dedicated to exploration, innovation, conservation, and education related to the oceans. Harbor Branch was founded in 1971 as a private non-profit organization. In December 2007, Harbor Branch joined Florida Atlantic University. The institute specializes in ocean engineering, at-sea operations, drug discovery and biotechnology from the oceans, coastal ecology and conservation, marine mammal research and conservation, aquaculture, and marine education. For more information, visit www.hboi.fau.edu.
Florida Atlantic University opened its doors in 1964 as the fifth public university in Florida. Today, the University serves more than 26,000 undergraduate and graduate students on seven campuses strategically located along 150 miles of Florida's southeastern coastline. Building on its rich tradition as a teaching university, with a world-class faculty, FAU hosts ten colleges: College of Architecture, Urban & Public Affairs, Dorothy F. Schmidt College of Arts & Letters, the Charles E. Schmidt College of Biomedical Science, the Barry Kaye College of Business, the College of Education, the College of Engineering & Computer Science, the Harriet L. Wilkes Honors College, the Graduate College, the Christine E. Lynn College of Nursing and the Charles E. Schmidt College of Science.
Gisele Galoustian | Newswise Science News
Further reports about: > Biomedical > Biotechnology > Chemo-preventatives > Marine science > Oceanographic Institution > Science TV > bioactive > cancer cells > chemical diversity > chronic inflammation > marine natural products > metastasis of existing tumors > oceans > pancreatic > pancreatic cancer > pancreatic cancer cells
Individual Receptors Caught at Work
19.10.2017 | Julius-Maximilians-Universität Würzburg
Rapid environmental change makes species more vulnerable to extinction
19.10.2017 | Universität Zürich
University of Maryland researchers contribute to historic detection of gravitational waves and light created by event
On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...
Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.
Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....
Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...
Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...
Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.
It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...
17.10.2017 | Event News
10.10.2017 | Event News
10.10.2017 | Event News
19.10.2017 | Materials Sciences
19.10.2017 | Materials Sciences
19.10.2017 | Physics and Astronomy