Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researcher discovers new type of spinal cord stem cell

16.09.2011
A group led by a University of British Columbia and Vancouver Coastal Health scientist has discovered a type of spinal cord cell that could function as a stem cell, with the ability to regenerate portions of the central nervous system in people with spinal cord injuries, multiple sclerosis or amyotrophic lateral sclerosis (Lou Gehrig’s disease).

The radial glial cells, which are marked by long projections that can forge through brain tissue, had never previously been found in an adult spinal cord. Radial glia, which are instrumental in building the brain and spinal cord during an organism’s embryonic phase, vastly outnumber other potential stem cells in the spinal cord and are much more accessible. Their findings were published online this week in PLoS One.

Stem cells have the capability of dividing into more specialized types of cells, either during the growth of an organism or to help replenish other cells. Scientists consider stem cells a promising way to replace injured or diseased organs and tissues.

The search for spinal stem cells of the central nervous system has until now focused deep in the spinal cord. Jane Roskams, a professor in the UBC Dept. of Zoology, broadened the search by using genetic profiles of nervous system stem cells that were developed and made publicly accessible by the Allen Institute for Brain Science in Seattle.

Roskams, collaborating with researchers at the Allen Institute, McGill University and Yale University, found cells with similar genes – radial glial cells – along the outside edge of spinal cords of mice.

“That is exactly where you would want these cells to be if you want to activate them with drugs while minimizing secondary damage,” says Roskams, a member ICORD (International Collaboration on Repair Discoveries) and the Brain Research Center, both partnerships of UBC and the Vancouver Coastal Health Research Institute.

Roskams’ team also found that radial glial cells in the spinal cord share a unique set of genes with other neural stem cells. Several of these – when mutated – can lead to human diseases, including some that target the nervous system. That discovery opens new possibilities for potential gene therapy treatments that would replace mutated, dysfunctional spinal cord cells with healthier ones produced by the radial glial cells.

“These long strands of radial glial cells amount to a potentially promising repair network that is perfectly situated to help people recover from spinal cord injuries or spinal disorders,” Roskams says. “For some reason, they aren’t re-activated very effectively in adulthood. The key is to find a way of stimulating them so they reprise their role of generating new neural cells when needed.”

The research was supported by the Canadian Institutes of Health Research, the Michael Smith Foundation for Health Research, the Natural Sciences and Engineering Research Council of Canada and the Jack Brown and Family Alzheimer’s Research Foundation.

The University of British Columbia (UBC) is one of North America’s largest public research and teaching institutions, and one of only two Canadian institutions consistently ranked among the world’s 40 best universities. Surrounded by the beauty of the Canadian West, it is a place that inspires bold, new ways of thinking that have helped make it a national leader in areas as diverse as community service learning, sustainability and research commercialization. UBC offers more than 50,000 students a range of innovative programs and attracts $550 million per year in research funding from government, non-profit organizations and industry through 7,000 grants.

Vancouver Coastal Health Research Institute (VCHRI) is the research body of Vancouver Coastal Health Authority, which includes BC’s largest academic and teaching health sciences centres: VGH, UBC Hospital, and GF Strong Rehabilitation Centre. In academic partnership with the University of British Columbia, VCHRI brings innovation and discovery to patient care, advancing healthier lives in healthy communities across British Columbia, Canada, and beyond. www.vchri.ca.

International Collaboration on Repair Discoveries (ICORD), is a world leading health research centre focused on spinal cord injury. From the lab-based cellular level of understanding injury to rehabilitation and recovery, our researchers are dedicated to the development and translation of more effective strategies to promote prevention, functional recovery, and improved quality of life after spinal cord injury. Located at Vancouver General Hospital in the Blusson Spinal Cord Centre, ICORD is supported by UBC Faculty of Medicine and Vancouver Coastal Health Research Institute. Visit www.icord.org.

The Brain Research Centre comprises more than 200 investigators with multidisciplinary expertise in neuroscience research ranging from the test tube, to the bedside, to industrial spin-offs. The centre is a partnership of UBC and VCH Research Institute. For more information, visit www.brain.ubc.ca.

Related topics: amyotrophic lateral sclerosis, Brain Research Centre, health, icord, medical research, multiple sclerosis, spinal cord, spinal cord injury, stem cells, Vancouver Coastal Health Research Institute, VCH, VCHRI

Brian Kladko | EurekAlert!
Further information:
http://www.ubc.ca

More articles from Life Sciences:

nachricht High-Speed Locomotion Neurons Found in the Brainstem
24.10.2017 | Universität Basel

nachricht Antibiotic resistance: a strain of multidrug-resistant Escherichia coli is on the rise
24.10.2017 | Deutsches Zentrum für Infektionsforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Salmonella as a tumour medication

HZI researchers developed a bacterial strain that can be used in cancer therapy

Salmonellae are dangerous pathogens that enter the body via contaminated food and can cause severe infections. But these bacteria are also known to target...

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

3rd Symposium on Driving Simulation

23.10.2017 | Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

 
Latest News

Single nanoparticle mapping paves the way for better nanotechnology

24.10.2017 | Physics and Astronomy

A quantum spin liquid

24.10.2017 | Physics and Astronomy

Antibiotic resistance: a strain of multidrug-resistant Escherichia coli is on the rise

24.10.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>