The grant is one of 14 awarded nationwide to research groups as part a $42 million expansion of the Human Microbiome Project. The human microbiome consists of beneficial and harmful microbes that include bacteria, viruses and fungi. The NIH launched the five-year, $157 million project in 2008 to serve as a research resource and to provide strategies for developing new therapies that manipulate the human microbiome to improve health.
Leading the UChicago-Argonne team will be Rustem Ismagilov, Professor in Chemistry. Joining him on the project are Eugene B. Chang, the Martin Boyer Professor of Medicine; Dionysios Antonopoulos, Assistant Professor of Medicine and biologist at Argonne, and Folker Meyer; associate director of Argonne’s Institute for Genomics and Systems Biology.
Historically, microbes have been studied in the laboratory as cultures of isolated species, but their growth is dependent upon a specific natural environment that is often difficult to duplicate. The NIH now seeks to develop techniques that can both increase the success rate for cultivating microbes and target cultivation efforts toward microbes of high biomedical interest.
The UChicago-Argonne team will use microfluidics to overcome the limitations of traditional cultivation and targeting methods by developing a single-cell confinement technology. Microfluidics is a means of precisely controlling the flow of liquids through channels thinner than a human hair.
The team will use sulfur-reducing bacteria from the human colon as the test system. These poorly understood bacteria are associated with ulcerative colitis and intra-abdominal infections, but the technology will generally apply to the identification and cultivation of all classes of microbes in the human gut microbiome.
Steve Koppes | Newswise Science News
Newly designed molecule binds nitrogen
23.02.2018 | Julius-Maximilians-Universität Würzburg
Atomic Design by Water
23.02.2018 | Max-Planck-Institut für Eisenforschung GmbH
A newly developed laser technology has enabled physicists in the Laboratory for Attosecond Physics (jointly run by LMU Munich and the Max Planck Institute of Quantum Optics) to generate attosecond bursts of high-energy photons of unprecedented intensity. This has made it possible to observe the interaction of multiple photons in a single such pulse with electrons in the inner orbital shell of an atom.
In order to observe the ultrafast electron motion in the inner shells of atoms with short light pulses, the pulses must not only be ultrashort, but very...
A group of researchers led by Andrea Cavalleri at the Max Planck Institute for Structure and Dynamics of Matter (MPSD) in Hamburg has demonstrated a new method enabling precise measurements of the interatomic forces that hold crystalline solids together. The paper Probing the Interatomic Potential of Solids by Strong-Field Nonlinear Phononics, published online in Nature, explains how a terahertz-frequency laser pulse can drive very large deformations of the crystal.
By measuring the highly unusual atomic trajectories under extreme electromagnetic transients, the MPSD group could reconstruct how rigid the atomic bonds are...
Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...
For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.
In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
15.02.2018 | Event News
13.02.2018 | Event News
12.02.2018 | Event News
23.02.2018 | Physics and Astronomy
23.02.2018 | Health and Medicine
23.02.2018 | Physics and Astronomy