Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Research team led by Cedars-Sinai identifies genes linked to ulcerative colitis

17.03.2010
Greater understanding of genetics of ulcerative colitis key to developing new treatments, researchers say

A study of the human genome led by Cedars-Sinai researchers has now identified genes linked to ulcerative colitis, offering clues as to what causes the condition and potential avenues for new therapies to treat the disease.

The study, published in Nature Genetics, examined genes of nearly 13,000 patients to determine which parts of the genome are linked to ulcerative colitis. The study demonstrated more than 30 regions of the genome are connected to the risk of developing ulcerative colitis.

“This gives us a number of insights into the disease,” said Dermot P.B. McGovern, M.D., Ph.D., director of Translational Medicine for the Inflammatory Bowel and Immunobiology Research Institute at Cedars-Sinai Medical Center and primary author of the paper. “An increased understanding of the genetics gives us some insight into what causes ulcerative colitis and will potentially help us indentify new therapies for ulcerative colitis.”

Understanding the genetics of the disease may also explain why the condition varies so much from patient to patient in severity, symptoms and response to therapies. In turn, said McGovern, this can lead to a more personalized approach to treating ulcerative colitis patients. For example, in addition to more effectively matching currently available medications to patients, the study may help identify entirely new avenues for research, enabling doctors to develop new treatments for ulcerative colitis.

Ulcerative colitis, one of the most common types of Inflammatory Bowel Disease or IBD, is a chronic digestive disorder. An estimated 1.4 million Americans have IBD, and about 30,000 new cases are diagnosed each year. Ulcerative colitis causes inflammation and ulcers in the top layers of the lining of the large intestine. The most common symptoms include abdominal pain, bloody diarrhea and bleeding from the rectum. Patients may also experience fatigue, weight loss and loss of appetite. Ulcerative colitis is a chronic relapsing condition with periods of remission interspersed with flares of disease, although about 10 percent of ulcerative colitis patients have symptoms chronically. Patients with ulcerative colitis can be at increased risk of developing colorectal cancer.

The study was a collaborative effort between the Inflammatory Bowel and Immunobiology Research Institute and The Medical Genetics Institute at Cedars-Sinai Medical Center, the National Institute of Diabetes and Digestive and Kidney Diseases IBD Genetics Consortium, the Genome Institute of Singapore, the Karolinksak Institutet in Sweden, the Swedish National Program for IBD genetics, The Swedish Organisation for Study of Inflammatory Bowel Diseases, and Harvard Medical School.

The Inflammatory Bowel Disease Center at Cedars-Sinai is a highly specialized patient care and research facility, dedicated to providing comprehensive diagnostic and treatment services to adults and children with IBD. In 2009, Cedars-Sinai was once again ranked among America’s best in Gastrointestinal Disorders by U.S. News and World Report.

Nicole White | Cedars-Sinai News
Further information:
http://dx.doi.org/10.1038/ng.549
http://www.cshs.org

Further reports about: Disease Genetics IBD Medical Wellness bowel immunobiology inflammatory ulcerative colitis

More articles from Life Sciences:

nachricht At last, butterflies get a bigger, better evolutionary tree
16.02.2018 | Florida Museum of Natural History

nachricht New treatment strategies for chronic kidney disease from the animal kingdom
16.02.2018 | Veterinärmedizinische Universität Wien

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

Im Focus: Interference as a new method for cooling quantum devices

Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters

Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...

Im Focus: Autonomous 3D scanner supports individual manufacturing processes

Let’s say the armrest is broken in your vintage car. As things stand, you would need a lot of luck and persistence to find the right spare part. But in the world of Industrie 4.0 and production with batch sizes of one, you can simply scan the armrest and print it out. This is made possible by the first ever 3D scanner capable of working autonomously and in real time. The autonomous scanning system will be on display at the Hannover Messe Preview on February 6 and at the Hannover Messe proper from April 23 to 27, 2018 (Hall 6, Booth A30).

Part of the charm of vintage cars is that they stopped making them long ago, so it is special when you do see one out on the roads. If something breaks or...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Fingerprints of quantum entanglement

16.02.2018 | Information Technology

'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers

16.02.2018 | Health and Medicine

Hubble sees Neptune's mysterious shrinking storm

16.02.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>