A study of the human genome led by Cedars-Sinai researchers has now identified genes linked to ulcerative colitis, offering clues as to what causes the condition and potential avenues for new therapies to treat the disease.
The study, published in Nature Genetics, examined genes of nearly 13,000 patients to determine which parts of the genome are linked to ulcerative colitis. The study demonstrated more than 30 regions of the genome are connected to the risk of developing ulcerative colitis.
“This gives us a number of insights into the disease,” said Dermot P.B. McGovern, M.D., Ph.D., director of Translational Medicine for the Inflammatory Bowel and Immunobiology Research Institute at Cedars-Sinai Medical Center and primary author of the paper. “An increased understanding of the genetics gives us some insight into what causes ulcerative colitis and will potentially help us indentify new therapies for ulcerative colitis.”
Understanding the genetics of the disease may also explain why the condition varies so much from patient to patient in severity, symptoms and response to therapies. In turn, said McGovern, this can lead to a more personalized approach to treating ulcerative colitis patients. For example, in addition to more effectively matching currently available medications to patients, the study may help identify entirely new avenues for research, enabling doctors to develop new treatments for ulcerative colitis.
Ulcerative colitis, one of the most common types of Inflammatory Bowel Disease or IBD, is a chronic digestive disorder. An estimated 1.4 million Americans have IBD, and about 30,000 new cases are diagnosed each year. Ulcerative colitis causes inflammation and ulcers in the top layers of the lining of the large intestine. The most common symptoms include abdominal pain, bloody diarrhea and bleeding from the rectum. Patients may also experience fatigue, weight loss and loss of appetite. Ulcerative colitis is a chronic relapsing condition with periods of remission interspersed with flares of disease, although about 10 percent of ulcerative colitis patients have symptoms chronically. Patients with ulcerative colitis can be at increased risk of developing colorectal cancer.
The study was a collaborative effort between the Inflammatory Bowel and Immunobiology Research Institute and The Medical Genetics Institute at Cedars-Sinai Medical Center, the National Institute of Diabetes and Digestive and Kidney Diseases IBD Genetics Consortium, the Genome Institute of Singapore, the Karolinksak Institutet in Sweden, the Swedish National Program for IBD genetics, The Swedish Organisation for Study of Inflammatory Bowel Diseases, and Harvard Medical School.
The Inflammatory Bowel Disease Center at Cedars-Sinai is a highly specialized patient care and research facility, dedicated to providing comprehensive diagnostic and treatment services to adults and children with IBD. In 2009, Cedars-Sinai was once again ranked among America’s best in Gastrointestinal Disorders by U.S. News and World Report.
20.11.2017 | Washington University in St. Louis
Carefully crafted light pulses control neuron activity
20.11.2017 | University of Illinois at Urbana-Champaign
The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.
Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...
Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.
That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...
Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.
During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....
The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.
Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...
Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...
15.11.2017 | Event News
15.11.2017 | Event News
30.10.2017 | Event News
20.11.2017 | Earth Sciences
20.11.2017 | Earth Sciences
20.11.2017 | Life Sciences