Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New research could stop tumour cells from spreading

03.04.2012
Researchers from the Department of Chemistry and Molecular Biology at the University of Gothenburg have managed for the first time to obtain detailed information about the role of the protein metastasin in the spread of tumour cells. Published recently in the renowned Proceedings of the National Academy of Sciences (PNAS), the study paves the way for the development of new drugs.
Metastasin is a protein with a key role in the spread of tumour cells.
Previous research has shown that it is activated through the binding of calcium ions and then binds to and modulates other proteins.

Increases the spread of tumour cells
One of metastasin’s binding partners is a motor protein called non-muscle myosin. Motor proteins are the driving force behind cell mobility. By binding to this protein, metastasin can increase the spread of tumour cells, acting as a kind of gas pedal for the cancer engine.

“Using a method called X-ray crystallography, we have managed for the first time to obtain detailed information on how metastasin binds to a motor protein, a process that facilitates the spread of tumour cells,” explains researcher Gergely Katona.

Detailed picture
It has been possible to image metastasin and calcium-ion-bound metastasin using X-ray crystallography before, but the researchers at the University of Gothenburg are the first to have imaged the structure of calcium-ion-activated metastasin with an attached non-muscle myosin fragment.

“This has given us information about regions of both metastasin and the motor protein that are crucial for metastasin’s ability to bind to the motor protein. This is important to know for drugs to be developed that block these specific regions and so prevent this binding.”

The image of the two molecules gives us a better understanding of how metastasin binds to the motor protein, so increasing cell mobility and the spread of tumour cells. This understanding in turn paves the way for the development of new drugs to prevent this harmful interaction between molecules and so stop tumour cells from spreading.

“The metastasin and the motor protein can be imaged as a snapshot, but the next stage is to create a kind of video to see how the molecules move when binding to one another,” explains Katona.

Gergely Katona is a researcher at the Department of Chemistry and Molecular Biology at the University of Gothenburg.

Bibliographic data:
Journal: PNAS - Proceedings of the National Academy of Sciences
Title: Crystal structure of the S100A4–nonmuscle myosin IIA tail fragment complex reveals an asymmetric target binding mechanism
Authors: Bence Kiss, Annette Duelli, László Radnai, Katalin A. Kékesi, Gergely Katona, and László Nyitray

For more information, please contact: Gergely Katona
Telephone: +46 (0)31 786 3959
E-mail: gergely.katona@chem.gu.se

Helena Aaberg | idw
Further information:
http://www.gu.se
http://www.science.gu.se/aktuellt/nyheter/Nyheter+Detalj//-ny-forskning-kan-forhindra-spridning-av-cancertumorceller.cid1071942

More articles from Life Sciences:

nachricht Strong Evidence – New Insight in Muscle Function
27.04.2015 | Austrian Science Fund FWF

nachricht Cell fusion ‘eats up’ the ‘attractive cell’ in flowering plants
27.04.2015 | Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fast and Accurate 3-D Imaging Technique to Track Optically-Trapped Particles

KAIST researchers published an article on the development of a novel technique to precisely track the 3-D positions of optically-trapped particles having complicated geometry in high speed in the April 2015 issue of Optica.

Daejeon, Republic of Korea, April 23, 2015--Optical tweezers have been used as an invaluable tool for exerting micro-scale force on microscopic particles and...

Im Focus: NOAA, Tulane identify second possible specimen of 'pocket shark' ever found

Pocket sharks are among the world's rarest finds

A very small and rare species of shark is swimming its way through scientific literature. But don't worry, the chances of this inches-long vertebrate biting...

Im Focus: Drexel materials scientists putting a new spin on computing memory

Ever since computers have been small enough to be fixtures on desks and laps, their central processing has functioned something like an atomic Etch A Sketch, with electromagnetic fields pushing data bits into place to encode data.

Unfortunately, the same drawbacks and perils of the mechanical sketch board have been just as pervasive in computing: making a change often requires starting...

Im Focus: Exploding stars help to understand thunderclouds on Earth

How is lightning initiated in thunderclouds? This is difficult to answer - how do you measure electric fields inside large, dangerously charged clouds? It was discovered, more or less by coincidence, that cosmic rays provide suitable probes to measure electric fields within thunderclouds. This surprising finding is published in Physical Review Letters on April 24th. The measurements were performed with the LOFAR radio telescope located in the Netherlands.

How is lightning initiated in thunderclouds? This is difficult to answer - how do you measure electric fields inside large, dangerously charged clouds? It was...

Im Focus: On the trail of a trace gas

Max Planck researcher Buhalqem Mamtimin determines how much nitrogen oxide is released into the atmosphere from agriculturally used oases.

In order to make statements about current and future air pollution, scientists use models which simulate the Earth’s atmosphere. A lot of information such as...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

HHL Energy Conference on May 11/12, 2015: Students Discuss about Decentralized Energy

23.04.2015 | Event News

“Developing our cities, preserving our planet”: Nobel Laureates gather for the first time in Asia

23.04.2015 | Event News

HHL's Entrepreneurship Conference on FinTech

13.04.2015 | Event News

 
Latest News

Strong Evidence – New Insight in Muscle Function

27.04.2015 | Life Sciences

The Future of Oil and Gas: Last of Her Kind

27.04.2015 | Power and Electrical Engineering

Tiny Lab Devices Could Attack Huge Problem of Drug-Resistant Infections

27.04.2015 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>