Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New research could stop tumour cells from spreading

03.04.2012
Researchers from the Department of Chemistry and Molecular Biology at the University of Gothenburg have managed for the first time to obtain detailed information about the role of the protein metastasin in the spread of tumour cells. Published recently in the renowned Proceedings of the National Academy of Sciences (PNAS), the study paves the way for the development of new drugs.
Metastasin is a protein with a key role in the spread of tumour cells.
Previous research has shown that it is activated through the binding of calcium ions and then binds to and modulates other proteins.

Increases the spread of tumour cells
One of metastasin’s binding partners is a motor protein called non-muscle myosin. Motor proteins are the driving force behind cell mobility. By binding to this protein, metastasin can increase the spread of tumour cells, acting as a kind of gas pedal for the cancer engine.

“Using a method called X-ray crystallography, we have managed for the first time to obtain detailed information on how metastasin binds to a motor protein, a process that facilitates the spread of tumour cells,” explains researcher Gergely Katona.

Detailed picture
It has been possible to image metastasin and calcium-ion-bound metastasin using X-ray crystallography before, but the researchers at the University of Gothenburg are the first to have imaged the structure of calcium-ion-activated metastasin with an attached non-muscle myosin fragment.

“This has given us information about regions of both metastasin and the motor protein that are crucial for metastasin’s ability to bind to the motor protein. This is important to know for drugs to be developed that block these specific regions and so prevent this binding.”

The image of the two molecules gives us a better understanding of how metastasin binds to the motor protein, so increasing cell mobility and the spread of tumour cells. This understanding in turn paves the way for the development of new drugs to prevent this harmful interaction between molecules and so stop tumour cells from spreading.

“The metastasin and the motor protein can be imaged as a snapshot, but the next stage is to create a kind of video to see how the molecules move when binding to one another,” explains Katona.

Gergely Katona is a researcher at the Department of Chemistry and Molecular Biology at the University of Gothenburg.

Bibliographic data:
Journal: PNAS - Proceedings of the National Academy of Sciences
Title: Crystal structure of the S100A4–nonmuscle myosin IIA tail fragment complex reveals an asymmetric target binding mechanism
Authors: Bence Kiss, Annette Duelli, László Radnai, Katalin A. Kékesi, Gergely Katona, and László Nyitray

For more information, please contact: Gergely Katona
Telephone: +46 (0)31 786 3959
E-mail: gergely.katona@chem.gu.se

Helena Aaberg | idw
Further information:
http://www.gu.se
http://www.science.gu.se/aktuellt/nyheter/Nyheter+Detalj//-ny-forskning-kan-forhindra-spridning-av-cancertumorceller.cid1071942

More articles from Life Sciences:

nachricht Water world
20.11.2017 | Washington University in St. Louis

nachricht Carefully crafted light pulses control neuron activity
20.11.2017 | University of Illinois at Urbana-Champaign

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

Im Focus: Wrinkles give heat a jolt in pillared graphene

Rice University researchers test 3-D carbon nanostructures' thermal transport abilities

Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

Antarctic landscape insights keep ice loss forecasts on the radar

20.11.2017 | Earth Sciences

Filling the gap: High-latitude volcanic eruptions also have global impact

20.11.2017 | Earth Sciences

Water world

20.11.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>