Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Research reveals how cells rebuild after mitosis


When cells divide, they need to rebuild their nucleus and organise their genome. New collaborative research from the University of Bristol demonstrates how cells achieve this through the unexpected deployment of filamentous actin (F-actin) to the nucleus.

The research, published online in Nature Cell Biology, provides the first evidence that actin polymerisation in the nucleus helps in reshaping the nucleus and reorganising the genome after cell division (mitosis).

Illustration of nuclear F-actin working to reshape the nucleus and organize the genome.

Credit: Claudia Stocker VividBiology

In mammals, including humans, the cell nucleus packages and protects the genome. When human cells divide, the nucleus is dissembled to allow segregation of the chromosomes. Once chromosome segregation is complete, new cells need to re-build their nucleus and organise their genome. This process, although essential for life, was poorly understood.

This work is in collaboration with Prof Robert Grosse's Laboratory (University of Marburg, Germany), who revealed the formation of transient and highly dynamic F-actin in the nucleus of daughter cells as they start rebuilding their nucleus after mitosis.

The polymerisation of actin (F-actin) readily occurs in the cytoplasm of cells; where it serves a very important function in controlling cell shape and enabling cells to crawl around. Discovering this transient and dynamic F-actin in nucleus soon after cells division, gave a hint that it may be required for rebuilding the nucleus and re-organising the genome.

Alice Sherrard co-first author of this study and a PhD student with Dr Abderrahmane Kaidi, developed and implemented complementary and interdisciplinary methods to visualise nuclear structure and genome organisation after cells division. In so doing, Alice revealed that disruption of the formation of F-actin results in cells failing to expand their nuclear volume as well as their inability to de-compact their genome. Because of these defects, cells become inefficient in retrieving genetic information encoded in their DNA; thus, they divide slower.

Principal investigator Dr Abderrahmane Kaidi, a specialist in cancer biology at the University of Bristol's School of Cellular and Molecular Medicine, says this discovery advances our fundamental knowledge of genome regulation in space and time, and could have major implications in understanding cancer and degeneration.

"This research highlights the importance of the spatiotemporal control of genome organisation for normal cells function, and we continue to define the principals that regulate these processes and their impact on cancer and degeneration," said Dr Kaidi.


This collaborative study is funded by Human Frontiers Science Program, Medical Research Council and Wellcome Trust; and benefited greatly from the Bristol Wolfson Bioimaging (Biomedical Sciences), and the Bristol Electron Microscopy Unit (Chemistry).

Media Contact

Shona East


Shona East | EurekAlert!

More articles from Life Sciences:

nachricht Make way for the mini flying machines
21.03.2018 | American Chemical Society

nachricht New 4-D printer could reshape the world we live in
21.03.2018 | American Chemical Society

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Researchers at Fraunhofer monitor re-entry of Chinese space station Tiangong-1

In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.

Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...

Im Focus: Alliance „OLED Licht Forum“ – Key partner for OLED lighting solutions

Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.

They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...

Im Focus: Mars' oceans formed early, possibly aided by massive volcanic eruptions

Oceans formed before Tharsis and evolved together, shaping climate history of Mars

A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...

Im Focus: Tiny implants for cells are functional in vivo

For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.

In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...

Im Focus: Locomotion control with photopigments

Researchers from Göttingen University discover additional function of opsins

Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...

All Focus news of the innovation-report >>>



Industry & Economy
Event News

Virtual reality conference comes to Reutlingen

19.03.2018 | Event News

Ultrafast Wireless and Chip Design at the DATE Conference in Dresden

16.03.2018 | Event News

International Tinnitus Conference of the Tinnitus Research Initiative in Regensburg

13.03.2018 | Event News

Latest News

TRAPPIST-1 planets provide clues to the nature of habitable worlds

21.03.2018 | Physics and Astronomy

The search for dark matter widens

21.03.2018 | Materials Sciences

Natural enemies reduce pesticide use

21.03.2018 | Life Sciences

Science & Research
Overview of more VideoLinks >>>