Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Research could lead to new drugs for major diseases

11.06.2012
Researchers at the University of Gothenburg, Sweden, are working to develop substances that can prevent parasites, bacteria and fungi from producing essential proteins, research that could, in the long term, lead to new drugs for several major diseases.

The World Health Organization (WHO) has announced that aminoacyl-tRNA synthetases – a type of enzyme – are important targets for the development of new drugs for several major diseases such as cancer, various parasitic diseases and bacterial and fungal infections.

These enzymes are involved in the production of proteins (protein synthesis) in all organisms. Their job is to ensure that the right amino acid is linked to the growing protein chain. These enzymes are essential for all living organisms.

Challenging research field
Researchers at the University of Gothenburg are currently undertaking basic research in this challenging field. The aim is to prevent the enzyme from producing proteins in bacteria, parasites or fungi, without stopping it from functioning in the human body.

"We're collaborating with researchers in several countries," says researcher Itedale Namro Redwan. "Our role has been to design and to synthesise substances that can be used for the development of drugs against parasitic diseases."

Looking for an effective substance
The enzymes' job of ensuring that the right amino acid is linked to the growing protein chain works in the same way in all types of cell, be they human or parasitic.

"The real challenge is identifying substances that act on enzymes in the parasite alone, without affecting the human enzymes at the same time," says Itedale Namro Redwan, who is making substances that can prevent bacterial and parasitic enzymes from functioning, but do not affect human enzymes. If this proves possible, it will help in the development of drugs for several major diseases.

"One of our main objectives has been to produce potent and selective substances that can be used to gain understanding of how these enzymes work. A greater understanding of their function would contribute to the development of medication for diseases like elephantitis."

Could prevent major diseases
Elephantitis, also known as filiaris, affects more than 120 million people in the developing world, and is caused by a worm that lives in the infected person's lymphatic vessels.

The potentially active molecules are being designed using computer-based molecular modelling techniques, with the resulting molecules subsequently synthesised via various chemical reactions.

"One of the best things about being a medicinal chemist is getting to plan a synthetic pathway that'll result in a specific substance, starting the reaction and then realising that the reaction's has worked," says Itedale Namro Redwan. "Better still is finding out that the molecule has performed as expected in a biological test."

The activity of the synthesised substances is assessed by partners through biological testing on, for example, aminoacyl-tRNA synthetase isolated from E. coli or filiaris parasites.

The thesis "Design and Synthesis of Potential Aminoacyl-tRNA Synthetase Inhibitors" has been successfully publicly defended at the University of Gothenburg on 11 May 2012.

For more information, please contact: Itedale Namro Redwan, Department of Chemistry and Molecular Biology
Telephone: +46 (0)31 786 9097
E-mail: itedale.namro@chem.gu.se

Bibliographic data
Title: Investigation, Optimisation and Synthesis of Sulfamoyloxy-linked Aminoacyl-AMP Analogues. Authors: Itedale Namro Redwan, Thomas Ljungdahl and Morten Grøtli.

Journal: Tetrahedron, 2012, 68, 1507-1514. http://www.sciencedirect.com/science/article/pii/S0040402011018783

Helena Aaberg | idw
Further information:
http://www.gu.se
http://hdl.handle.net/2077/28794

More articles from Life Sciences:

nachricht New catalyst controls activation of a carbon-hydrogen bond
21.11.2017 | Emory Health Sciences

nachricht The main switch
21.11.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Nanoparticles help with malaria diagnosis – new rapid test in development

The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.

Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

Previous evidence of water on mars now identified as grainflows

21.11.2017 | Physics and Astronomy

NASA's James Webb Space Telescope completes final cryogenic testing

21.11.2017 | Physics and Astronomy

New catalyst controls activation of a carbon-hydrogen bond

21.11.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>