Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New research provides new insight into age-related muscle decline

25.09.2009
Research published in the journal Genetics suggests new ways to stop byproducts from the air we breathe from harming our muscles

If you think the air outside is polluted, a new research report in the September 2009 issue of the journal Genetics (http://www.genetics.org) might make you to think twice about the air inside our bodies too.

That's because researchers show how about 3 percent of the air we breathe gets converted into harmful superoxides, which ultimately harm our muscles. Specifically, these superoxides lead to the creation of a toxic molecule called "reactive oxygen species" or ROS, which is shown to be particularly harmful to muscle tissue, and may lead to problems ranging from aging and frailty to Parkinson's disease and cancer.

"At a minimum, we hope this research leads to new ways of addressing inevitable declining physical performance and other age-dependent infirmities among the elderly," said Atanu Duttaroy, associate professor of biology at Howard University in Washington, D.C. and one of the researchers involved in the work.

To make their discovery, Duttaroy and colleagues built on their previous research showing that ROS-induced cellular damage happens in the same way in fruit flies and in mice. They started with fruit flies that lack mitochondrial superoxide dismutase enzyme (SOD), which provides the primary line of defense against ROS by capturing the superoxides and converting them to water. This lack of SOD caused the fruit flies to die within a day after hatching. Then, through genetic manipulation, the researchers "turned on" the production of SOD separately in nerves and muscles. SOD in nerves did not appear to make a significant difference in prolonging the fruit flies' lives, but it did make a difference when it was activated in their muscles. The survival of fruit flies with SOD "turned on" in their muscles increased, and for several days, they remained as active as their normal counterparts. Measurement of their muscle activity also showed that SOD helped the muscle work normally, helping survival.

"It's long been known that the oxygen we breath can be toxic, and this work provides a concrete example of that with real consequences." said Mark Johnston, Editor-in-Chief of the journal Genetics. "As baby boomers get older, the need to help older people stay mobile and fit has never been greater in our lifetimes. This study helps address this need by providing insight into what causes physical decline, and in turn, bringing us a step closer toward finding ways to stop or reverse it."

DETAILS: Tanja Godenschwege, Renée Forde, Claudette P. Davis, Anirban Paul, Kristopher Beckwith, and Atanu Duttaroy

Mitochondrial Superoxide Radicals Differentially Affect Muscle Activity and Neural Function Genetics 2009 183: 175-184. http://www.genetics.org/cgi/content/abstract/183/1/175

Since 1916, Genetics (http://www.genetics.org) has covered high quality, original research on a range of topics bearing on inheritance, including population and evolutionary genetics, complex traits, developmental and behavioral genetics, cellular genetics, gene expression, genome integrity and transmission, and genome and systems biology. Genetics, the peer-reviewed, peer-edited journal of the Genetics Society of America is one of the world's most cited journals in genetics and heredity.

Tracey DePellegrin Connelly | EurekAlert!
Further information:
http://www.andrew.cmu.edu

More articles from Life Sciences:

nachricht Discovery of a Key Regulatory Gene in Cardiac Valve Formation
24.05.2017 | Universität Basel

nachricht Carcinogenic soot particles from GDI engines
24.05.2017 | Empa - Eidgenössische Materialprüfungs- und Forschungsanstalt

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

Physicists discover mechanism behind granular capillary effect

24.05.2017 | Physics and Astronomy

Measured for the first time: Direction of light waves changed by quantum effect

24.05.2017 | Physics and Astronomy

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>