Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New research identifies a possible finite number of viruses

03.09.2013
Scientists determine new strategy to estimate total viral diversity in mammals

EcoHealth Alliance, a nonprofit organization that focuses on local conservation and global health issues, and the Center for Infection and Immunity (CII) at Columbia University's Mailman School of Public Health announced a new strategy to identify the total number of wildlife viruses that could potentially cause emerging disease outbreaks that threaten both public and wildlife health.

Combining field investigations with a new statistical approach, scientists estimate that there may exist a minimum of 320,000 viruses awaiting discovery from mammals alone. With over three-quarters of the emerging infectious diseases originating from wildlife this research gives scientists an estimate of the number of viral agents that may eventually cause a pandemic.

Diseases such as SARS, West Nile virus, HIV/AIDS, Ebola and Avian influenza are all examples of a zoonotic diseases – those that originate in wildlife and are spread to humans. "For decades, we've faced the threat of future pandemics without knowing how many viruses are lurking in the environment, in wildlife, waiting to emerge. Finally we have a breakthrough – there aren't millions of unknown virus, just a few hundred thousand, and given the technology we have it's possible that in my lifetime, we'll know the identity of every unknown virus on the planet," says Peter Daszak, PhD, corresponding author and president of EcoHealth Alliance.

The Economics of Emerging Infectious Diseases

Emerging disease outbreaks cause both social concerns and economic problems. The threat alone of a new emerging disease such as the newly discovered Middle East Respiratory Syndrome (MERS) can directly affect the economic stability of the global economy. Economic losses due to the SARS outbreak was estimated to be anywhere from $15 billion to more than $50 billion. Scientists in this new study worked to establish a quantifiable cost to the discovery of these 320,000 new viruses: $1.2 million for one host species such as the Indian flying fox bat or a total of $6.3 billion for all mammals. The cost of discovering these viruses is a fraction of the cost required to respond to a global pandemic like H1N1 influenza or SARS. Given the disproportionate cost of discovering the rarest of the rare, scientists showed that limiting efforts to 85 percent of estimated viral diversity would bring the cost down to $1.4 billion.

"Historically, our whole approach to discovery has been altogether too random," says lead author Simon Anthony, D.Phil, a scientist at the Center for Infection and Immunity (CII) at Columbia University's Mailman School of Public Health. "What we currently know about viruses is very much biased towards those that have already spilled over into humans or animals and emerged as diseases. But the pool of all viruses in wildlife, including many potential threats to humans, is actually much deeper. A more systematic, multidisciplinary, and One Health framework is needed if we are to understand what drives and controls viral diversity and following that, what causes viruses to emerge as disease-causing pathogens."

EcoHealth Alliance scientists continue to work on the frontlines of viral discovery in emerging disease hotspots regions around the world focused at the intersection of the environment, health, and capacity building. EcoHealth Alliance is focused on understanding the environmental drivers of zoonotic disease emergence and promoting the conservation of all species.

"PREDICT has already discovered more than 240 novel viruses throughout the world in areas where people and animals live in close contact and depend on the same natural resources," says study co-author Jonna Mazet, PhD, director of the UC Davis One Health Institute and co-director of PREDICT. "That includes new coronaviruses, like the ones that cause SARS and the new Middle East Respiratory Syndrome."

The current study is the result of a multidisciplinary collaboration between 21 molecular virologists, ecologists, veterinarians, and mathematicians from institutions, including the Center for Infection and Immunity at Columbia's Mailman School; EcoHealth Alliance, National Autonomous University of Mexico, University of California Davis; International Centre for Diarrhoeal Disease Research, Dhaka (Bangladesh); Princeton University; National Institutes of Health; and Chittagong Veterinary and Animal Sciences University (Bangladesh).

"To quote Benjamin Franklin, an ounce of prevention is worth a pound of cure," says W. Ian Lipkin, MD, director of CII. "Our goal is to provide the viral intelligence needed for the global public health community to anticipate and respond to the continuous challenge of emerging infectious diseases." The study, titled "A strategy to estimate unknown viral diversity in mammals," appears in the journal mBio. Support for the research was provided by United States Agency for International Development (USAID) and the PREDICT Project.

About EcoHealth Alliance

Building on over 40 years of groundbreaking science, EcoHealth Alliance is a global, nonprofit organization dedicated to protecting wildlife and safeguarding human health from the emergence of disease. The organization develops ways to combat the effects of damaged ecosystems on human and wildlife health. Using environmental and health data covering the past 60 years, EcoHealth Alliance scientists created the first-ever, global disease hotspots map that identified at-risk regions, to help predict and prevent the next pandemic crisis. That work is the foundation of EcoHealth Alliance's rigorous, science-based approach, focused at the intersection of the environment, health, and capacity building. Working in the U.S. and more than 20 countries worldwide, EcoHealth Alliance's strength is founded on innovations in research, training, global partnerships, and policy initiatives. For more information, please visit http://www.ecohealthalliance.org.

Anthony M. Ramos | EurekAlert!
Further information:
http://www.ecohealthalliance.org

More articles from Life Sciences:

nachricht Immune Defense Without Collateral Damage
23.01.2017 | Universität Basel

nachricht The interactome of infected neural cells reveals new therapeutic targets for Zika
23.01.2017 | D'Or Institute for Research and Education

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Quantum optical sensor for the first time tested in space – with a laser system from Berlin

For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.

According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Tracking movement of immune cells identifies key first steps in inflammatory arthritis

23.01.2017 | Health and Medicine

Electrocatalysis can advance green transition

23.01.2017 | Physics and Astronomy

New technology for mass-production of complex molded composite components

23.01.2017 | Process Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>