New research published in the online open access journal BMC Genomics is the first to show that this chemical can affect the breasts' genomic profile.
Jose Russo and coworkers from the Fox Chase Cancer Center in Philadelphia, along with colleagues from the University of Alabama in Birmingham, US, fed lactating rats with butyl benzyl phthalate (BBP), which their offspring then absorbed via breast milk. The offspring ingested levels of chemical estimated to be nearly equivalent to the Environmental Protection Agency's safe dose limit of BBP for humans.
The researchers found that BBP had a transitory effect on certain characteristics of the female offspring of the rats, such as the ratio of uterine weight to body weight and the genetic profile of the mammary gland. Dr Russo stated: "We are the first to report that neonatal/prepubertal exposure to BBP induced modifications in the gene expression of the mammary tissue."
Although these effects wore off once exposure to BBP was removed, the subtle changes in the mammary gland may have an effect later in life.
BBP is widely used as a plasticizer, an additive used to soften polymers, and is found in household fittings such as pipes, vinyl floor tiles and carpet backing. This type of chemical is known to be an endocrine disruptor, which mimics the effect of hormones. Endocrine disruptors are known to damage wildlife and they have also been implicated in reduced sperm counts and neurological problems in humans.
One step closer to reality
20.04.2018 | Max-Planck-Institut für Entwicklungsbiologie
The dark side of cichlid fish: from cannibal to caregiver
20.04.2018 | Veterinärmedizinische Universität Wien
University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.
Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.
Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.
The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...
Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.
Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...
In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...
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12.04.2018 | Event News
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20.04.2018 | Physics and Astronomy
20.04.2018 | Interdisciplinary Research
20.04.2018 | Physics and Astronomy