Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

MIT sculpts 3D particles with light

03.12.2007
Medical applications could include diagnostics, tissue engineering

MIT engineers have used ultraviolet light to sculpt three-dimensional microparticles that could have many applications in medical diagnostics and tissue engineering. For example, they could be designed to act as probes to detect certain molecules, such as DNA, or to release drugs or nutrients.

The new technique offers unprecedented control over the size, shape and texture of the particles. It also allows researchers to design particles with specific chemical properties, such as porosity (a measure of the void space in a material that can affect how fast different molecules can diffuse through the particles).

“With this method, you can rationally design particles, and precisely place chemical properties,” said Patrick Doyle, associate professor of chemical engineering. Doyle is one of the authors of a paper on the work that will appear in the Dec. 3 issue of the journal Angewandte Chemie, published by the German Chemical Society.

... more about:
»Control »Engineering »LIGHT »Mask »nutrient »size

The research team started with a method that Doyle and his students reported in a 2006 issue of Nature Materials to create two- dimensional particles. Called continuous flow lithography, this approach allows shapes to be imprinted onto flowing streams of liquid polymers. Wherever pulses of ultraviolet light strike the flowing stream of small monomeric building blocks, a reaction is set off that forms a solid polymeric particle. They have now modified that method to add three-dimensionality.

This process can create particles very rapidly: Speeds range from 1,000 to 10,000 particles per second, depending on the size and shape of the particles. The particles range in size from about a millionth of a meter to a millimeter.

The team's new process works by shining ultraviolet light through two transparency masks, which define and focus the light before it reaches the flowing monomers. The first mask, which controls the size and shape of the particles, is part of the technique reported last year by Doyle and his students. The second mask, which is based on MIT professor Edwin Thomas' work in multibeam lithography, adds three- dimensional texture and other physical traits, such as porosity.

The collaboration sprung from a conversation between Ji-Hyun Jang, a postdoctoral associate in Thomas' lab, and Dhananjay Dendukuri, a recent Ph.D. recipient in Doyle's lab, who are also authors on the paper.

“It's very easy to integrate the (second) phase mask into the microfluidic apparatus,” said Thomas, Morris Cohen Professor of Materials Science and Engineering and head of the Department of Materials Science and Engineering. “Professor Doyle was controlling the overall shape, and now what we're doing is controlling these inner labyrinth networks.”

Adding inner texture is desirable because it increases the particles'
surface-to-volume ratio, which means if the particle is loaded with probes, there are more potential binding sites for target molecules.

In a paper published in Science earlier this year, Doyle and MIT graduate student Daniel Pregibon showed that the particles can be used as probes to identify DNA and other molecules.

Other applications for the particles include tissue engineering. For example, they could form a scaffold that would both provide structural support for growing cells and release growth factors and other nutrients. The particles can be designed so diffusion occurs in a particular direction, allowing researchers to control the direction of nutrient flow.

Alan Hatton, the Ralph Landau Professor of Chemical Engineering Practice, is also an author on the paper.

This research was funded by the U.S. Army Research Office through the MIT Institute for Soldier Nanotechnologies.

Elizabeth A. Thomson | MIT News Office
Further information:
http://www.mit.edu

Further reports about: Control Engineering LIGHT Mask nutrient size

More articles from Life Sciences:

nachricht The irresistible fragrance of dying vinegar flies
16.08.2017 | Max-Planck-Institut für chemische Ökologie

nachricht How protein islands form
15.08.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

Im Focus: Scientists improve forecast of increasing hazard on Ecuadorian volcano

Researchers from the University of Miami (UM) Rosenstiel School of Marine and Atmospheric Science, the Italian Space Agency (ASI), and the Instituto Geofisico--Escuela Politecnica Nacional (IGEPN) of Ecuador, showed an increasing volcanic danger on Cotopaxi in Ecuador using a powerful technique known as Interferometric Synthetic Aperture Radar (InSAR).

The Andes region in which Cotopaxi volcano is located is known to contain some of the world's most serious volcanic hazard. A mid- to large-size eruption has...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

New thruster design increases efficiency for future spaceflight

16.08.2017 | Physics and Astronomy

Transporting spin: A graphene and boron nitride heterostructure creates large spin signals

16.08.2017 | Materials Sciences

A new method for the 3-D printing of living tissues

16.08.2017 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>