Bioethanol is produced by a variety of micro-organisms under anaerobic conditions, i.e. in the absence of oxygen. For biotechnical methods of fuel production to be competitive with conventional procedures, it is necessary to use such variants of micro-organisms whose enzymes can produce biofuels at low temperatures, with a high pH tolerance, and with minimal energy consumption. With this goal in mind, DASGIP has optimized its parallel bioreactor systems: The user can ferment and compare several different micro-organisms under the same conditions (screening), or the same micro-organism can be compared under different conditions (optimization). The system allows continuous monitoring of important variables such as pH value and redox potential, gassing parameters and temperature.
The separate measuring of pH and redox potential is particularly important. In anaerobic metabolism of micro-organisms a negative redox potential is essential for specific enzyme activities. As even small changes in pH can influence the redox potential, one can see how the pH value is an important parameter that must be monitored individually. DASGIP’s PH4RD4 module can measure redox potential and pH simultaneously and individually in four reactors. By controlling these conditions with very high precision, the identification of the ideal reaction parameters for the cells is simplified. The information density accelerates the selection of strains and the best fermentation parameters. In addition, the gassing module MF4 supplies the bioreactor with up to four input gasses. Each gas has its own independent lead, which can be selected as necessary. The user can even combine gasses that react with each other in the same gassing system and thus optimize the conditions of testing.
DASGIP’s parallel bioreactor systems are already used worldwide in industrial biotechnology. One example is in the field of enzyme technology and biocatalysis. Professor Mani Subramanian, Director of the Center for Biocatalysis and Bioprocessing at the University of Iowa, utilizes the DASGIP fermentation system in the field of enzyme technology: This is being done in two steps. First, the Pichia biomass and enzyme expression is optimized by monitoring and controlling pH, temperature, oxygen and enzyme induction by methanol. In a second step the product yield with the Pichia cells is maximized by “reaction engineering” in the DASGIP system. The enzyme system they are working with is glycolate oxidase. The research activities of Professor Dirk Weuster-Botz from the Technical University of Munich, Germany, which has already been presented by DASGIP, are addressed to the development of alternative procedures in industrial biotechnology as well. The project is supported by the Deutsche Bundesstiftung Umwelt (DBU, one of Europe's largest foundations promoting innovative and exemplary environmental projects). The goal is to develop a fermentation process for the industrial production of succinic acid in Sacharomyces cerevisiae. Succinic acid is an important chemical resource which is used widely in the pharmaceutical and chemical industry.
Within the industrial biotechnology, a big challenge for science and industry has recently emerged: How to identify new anaerobic micro-organisms that are able to produce biofuels from organic substrates efficiently and economically. In its resolution to decrease the yearly CO2 emission, the European Commission has decided that by 2010, at least 5.75% of the total fuel consumption in the EU should come from biological sources. This corresponds to about 27 billion litres of biofuel. In the USA, it is intended to increase the admixture of bioethanol up to 17% by 2017. This breaks an important operational area to DASGIP’s parallel bioreactor systems, in a market with a high growth potential. At the Biotechnica in Hanover (9 - 11 October 2007, booth G25, hall 9) DASGIP will present a fermentation system optimized for anaerobic microbiology.
DASGIP AG develops and manufactures technologically advanced Parallel Bioreactor Systems for the cultivation of microbial and mammalian cells at bench top and pilot scale. Process engineers, scientists and product developers from biotechnological, pharmaceutical and chemical companies as well as research institutions use DASGIP Parallel Bioreactor Systems for their biotechnological processes and benefit from increased productivity, high reproducibility, and ease of scale up, resulting in accelerated product development cycles. DASGIP is located in Juelich (Germany) and Shrewsbury MA (USA).Contact
Professor Mani Subramanian, University of Iowa, firstname.lastname@example.orgDASGIP AG
Jennefer Vogt | DASGIP AG
For a chimpanzee, one good turn deserves another
27.06.2017 | Max-Planck-Institut für Mathematik in den Naturwissenschaften (MPIMIS)
New method to rapidly map the 'social networks' of proteins
27.06.2017 | Salk Institute
An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.
Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...
Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.
Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...
Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.
As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...
Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.
With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...
Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine
Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...
19.06.2017 | Event News
13.06.2017 | Event News
13.06.2017 | Event News
27.06.2017 | Power and Electrical Engineering
27.06.2017 | Information Technology
27.06.2017 | Physics and Astronomy