Bioethanol is produced by a variety of micro-organisms under anaerobic conditions, i.e. in the absence of oxygen. For biotechnical methods of fuel production to be competitive with conventional procedures, it is necessary to use such variants of micro-organisms whose enzymes can produce biofuels at low temperatures, with a high pH tolerance, and with minimal energy consumption. With this goal in mind, DASGIP has optimized its parallel bioreactor systems: The user can ferment and compare several different micro-organisms under the same conditions (screening), or the same micro-organism can be compared under different conditions (optimization). The system allows continuous monitoring of important variables such as pH value and redox potential, gassing parameters and temperature.
The separate measuring of pH and redox potential is particularly important. In anaerobic metabolism of micro-organisms a negative redox potential is essential for specific enzyme activities. As even small changes in pH can influence the redox potential, one can see how the pH value is an important parameter that must be monitored individually. DASGIP’s PH4RD4 module can measure redox potential and pH simultaneously and individually in four reactors. By controlling these conditions with very high precision, the identification of the ideal reaction parameters for the cells is simplified. The information density accelerates the selection of strains and the best fermentation parameters. In addition, the gassing module MF4 supplies the bioreactor with up to four input gasses. Each gas has its own independent lead, which can be selected as necessary. The user can even combine gasses that react with each other in the same gassing system and thus optimize the conditions of testing.
DASGIP’s parallel bioreactor systems are already used worldwide in industrial biotechnology. One example is in the field of enzyme technology and biocatalysis. Professor Mani Subramanian, Director of the Center for Biocatalysis and Bioprocessing at the University of Iowa, utilizes the DASGIP fermentation system in the field of enzyme technology: This is being done in two steps. First, the Pichia biomass and enzyme expression is optimized by monitoring and controlling pH, temperature, oxygen and enzyme induction by methanol. In a second step the product yield with the Pichia cells is maximized by “reaction engineering” in the DASGIP system. The enzyme system they are working with is glycolate oxidase. The research activities of Professor Dirk Weuster-Botz from the Technical University of Munich, Germany, which has already been presented by DASGIP, are addressed to the development of alternative procedures in industrial biotechnology as well. The project is supported by the Deutsche Bundesstiftung Umwelt (DBU, one of Europe's largest foundations promoting innovative and exemplary environmental projects). The goal is to develop a fermentation process for the industrial production of succinic acid in Sacharomyces cerevisiae. Succinic acid is an important chemical resource which is used widely in the pharmaceutical and chemical industry.
Within the industrial biotechnology, a big challenge for science and industry has recently emerged: How to identify new anaerobic micro-organisms that are able to produce biofuels from organic substrates efficiently and economically. In its resolution to decrease the yearly CO2 emission, the European Commission has decided that by 2010, at least 5.75% of the total fuel consumption in the EU should come from biological sources. This corresponds to about 27 billion litres of biofuel. In the USA, it is intended to increase the admixture of bioethanol up to 17% by 2017. This breaks an important operational area to DASGIP’s parallel bioreactor systems, in a market with a high growth potential. At the Biotechnica in Hanover (9 - 11 October 2007, booth G25, hall 9) DASGIP will present a fermentation system optimized for anaerobic microbiology.
DASGIP AG develops and manufactures technologically advanced Parallel Bioreactor Systems for the cultivation of microbial and mammalian cells at bench top and pilot scale. Process engineers, scientists and product developers from biotechnological, pharmaceutical and chemical companies as well as research institutions use DASGIP Parallel Bioreactor Systems for their biotechnological processes and benefit from increased productivity, high reproducibility, and ease of scale up, resulting in accelerated product development cycles. DASGIP is located in Juelich (Germany) and Shrewsbury MA (USA).Contact
Professor Mani Subramanian, University of Iowa, email@example.comDASGIP AG
Jennefer Vogt | DASGIP AG
Don't Give the Slightest Chance to Toxic Elements in Medicinal Products
23.03.2018 | Physikalisch-Technische Bundesanstalt (PTB)
North and South Cooperation to Combat Tuberculosis
22.03.2018 | Universität Zürich
Satellites in near-Earth orbit are at risk due to the steady increase in space debris. But their mission in the areas of telecommunications, navigation or weather forecasts is essential for society. Fraunhofer FHR therefore develops radar-based systems which allow the detection, tracking and cataloging of even the smallest particles of debris. Satellite operators who have access to our data are in a better position to plan evasive maneuvers and prevent destructive collisions. From April, 25-29 2018, Fraunhofer FHR and its partners will exhibit the complementary radar systems TIRA and GESTRA as well as the latest radar techniques for space observation across three stands at the ILA Berlin.
The "traffic situation" in space is very tense: the Earth is currently being orbited not only by countless satellites but also by a large volume of space...
An international team of researchers has discovered a new anti-cancer protein. The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. The researchers led by Prof. Michael N. Hall from the Biozentrum, University of Basel, report in “Nature” that LHPP can also serve as a biomarker for the diagnosis and prognosis of liver cancer.
The incidence of liver cancer, also known as hepatocellular carcinoma, is steadily increasing. In the last twenty years, the number of cases has almost doubled...
In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.
Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...
Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.
They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...
A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...
23.03.2018 | Event News
19.03.2018 | Event News
16.03.2018 | Event News
23.03.2018 | Materials Sciences
23.03.2018 | Agricultural and Forestry Science
23.03.2018 | Physics and Astronomy