Schizophrenia is a serious and common disease that can cause hallucinations, delusions and apathy. Problems with memory, social cognition and other intellectual abilities are also common.
"Schizophrenic patients can be treated with anti-psychotic drugs, but the treatment does not help cognitive disturbances or impaired social function to any appreciable degree. We believe that this is due to an imbalance in the brain's nitric oxide system, and if this is the case, we may be able to develop a completely new type of treatment," says pharmacologist Caroline Wass.
In these studies, rate and mice were given a drug called phencyclidine. This substance causes a schizophrenia-like state in humans.
"Rats and mice don't become schizophrenic, but the drug has a similar effect on thought processes in rodents to the effect it has in humans," says Caroline Wass.
The animals' learning capacity, memory and social interaction were measured using several different behaviour models. When the animals were treated with a substance that blocks brain nitric oxide production, they became resistant to the schizophrenia-like effects of phencyclidine.
The research team will shortly initiate a patient study in order to find out whether blocking brain nitric oxide production can alleviate cognitive disturbances in patients with schizophrenia.
"In the future it is possible that drugs that affect the regulation of nitric oxide in the brain can be used to supplement currently existing anti-psychotic agents. The hope is that nitric oxide inhibiting drugs will alleviate the cognitive disturbances that also lie behind the impairments of social function, significantly improving the chances of a good life for schizophrenic patients," says Caroline Wass.SCHIZOPHRENIA FACTS
For further information contact: Caroline Wass, Pharmacologist, telephone: +46 (0)31 786 3420, +46 (0)70 498 4958, email: firstname.lastname@example.org Supervisors: Associate professor Lennart Svensson, telephone: +46 (0)31 786 3402, email: email@example.com Professor Jörgen Engel, telephone: +46 (0)31 786 3416, email: firstname.lastname@example.org Professor Trevor Archer, telephone: +46 (0)31 786 4694, email: email@example.com Dr. Daniel Klamer PhD, telephone: +46 (0)31 786 3403, email: firstname.lastname@example.orgPressofficer: Elin Lindström Claessen; email@example.com;
Elin Lindström Claessen | idw
Novel mechanisms of action discovered for the skin cancer medication Imiquimod
21.10.2016 | Technische Universität München
Second research flight into zero gravity
21.10.2016 | Universität Zürich
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...
'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.
Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
21.10.2016 | Health and Medicine
21.10.2016 | Information Technology
21.10.2016 | Materials Sciences