Alzheimer’s disease has several different causes. Since many patients have a close relative who also developed the disease, heredity is believed to be one of the most important factors.
“There is a previously identified Alzheimer’s gene that indicates an elevated risk of developing the disease, but we want to find more genes with a strong connection to Alzheimer’s. The earlier we can predict that a patient risks developing the disease, the better health-care providers can prevent and treat it,” says the research Annica Sjölander.
In her dissertation, Annica Sjölander studied different variants of a gene called CDC2. DNA analyses of blood samples from both patients and healthy individuals showed that one gene variant was considerably more common among patients with Alzheimer’s disease.
“This is the first discovery of a connection between this specific gene and Alzheimer’s. The findings must be confirmed in several other studies before we can be absolutely certain that it is a new Alzheimer’s gene that we have found,” explains Annica Sjölander.
In the study this gene variant was found in roughly half of all patients with Alzheimer’s, compared with 35 percent of the healthy control group.
The dissertation shows that patients with Alzheimer’s disease who were carriers of the gene variant also had higher levels of the protein tau, which is associated with the disease. In patients with the disease the mean level of tau in the spinal marrow fluid is about three times higher than the level in healthy individuals of the same age.
The gene CDC2 is responsible for one of the phases when a cell divides and is only active when cell division is in progress. Other research has shown that CDC2 in Alzheimer’s patients is turned on inside nerve cells where cell division does not normally take place.
“No one knows why the gene is activated, but it may be the result of a defect in the gene. It is also possible to speculate that the body is perhaps trying to compensate for lost nerve cells by having nerve cells divide,” says Annica Sjölander.FACTS ABOUT ALZHEIMER’S DISEASE
Title of dissertation: Alzheimer’s Disease: effect of tau-related genes on the pathology, neurochemistry and risk of disease.
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Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
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Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
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Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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