Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Cellular therapy of a stroke

20.11.2007
Specialists of the “Trans-Technologies” Open Joint-Stock Company, with participation of Scientific Research Institute of Experimental Medicine, Russian Academy of Medical Sciences (St. Petersburg), have tested on rats the capabilities of cellular therapy for ischemic stroke treatment. It has turned out that intravenous transplantation of mesenchymal stem cells restores cerebrum blood supply and protects its nerve cells from death.

Under anaesthetic, the rats’ medium cerebral artery was pinched in order to impair the blood supply in the left hemisphere. Three days later, the animals were intravenously injected the mesenchymal stem cells (MSC) from the marrow.

These cells are able to differentiate into the cells of other tissues, including nerve cells. Part of the animals was false-operated – the operation was performed on them but the artery had not been pinched. The reference group animals’ artery was pinched but the stem cells were not introduced.

The MSCs for transplantation were singled out from the marrow of thigh-bones of other animals of the same laboratory line, the MSCs were marked by a fluorescent dye and injected into the laboratory rats’ caudal vein. The animals’ cerebrum was investigated six weeks later.

... more about:
»MSC »Transplantation »stem cells »stroke »therapy

There turned out to be unexpectedly few luminescent cells in the cerebrum specimen, and they were located not in the affected cortex zone but nearby ventricles of brain. This is strange as the specialists of “Tans-Technologies” have experimentally proved that stem cells introduced into the bloodstream come to the damaged tissue in several days. But nevertheless the stem cells introduction turned out effective for restoration of the affected brain.

The area of affected zone with the experimental rats was less than that with the untreated animals. Transplantation enables to preserve the parts of brain responsible for formation of emotions and motion regulation. With the untreated rats, these sections were noticeably damaged. Their stroke area was surrounded with an extensive zone of dying nerve cells.

The stem cells increased almost by twice the number of blood vessels in the injured left hemisphere, which contributed to cerebral blood supply restoration. It is interesting that more vessels appeared in the symmetrical unaffected hemisphere. This phenomenon has not been described in scientific publications, therefore the researchers are planning to investigate it separately.

Thanks to the stem cells, the rats successfully passed the test in two or three weeks after transplantation. They became calmer, they better orientated themselves in space and memorized disposition of surrounding objects. Besides, the animals restored symmetry of reactions in the left and the right side of the body and in utilization of extremities.

In the researchers’ opinion, the mesenchymal stem cells (MSCs) is practically an ideal material for cellular therapy as they can be introduced directly into the blood. This allows to avoid serious operations under general anaesthetic, which are necessary for cell injection directly into the brain.

Although the researchers are now unable to fully explain the MSCs mechanism of action, but their beneficial action on the brain after a stroke is evident. Possibly, in case of earlier MSC transplantation, more cells will be able to get into the brain, and the beneficial action will be even more apparent.

Nadezda Markina | alfa
Further information:
http://www.informnauka.ru

Further reports about: MSC Transplantation stem cells stroke therapy

More articles from Life Sciences:

nachricht Could this protein protect people against coronary artery disease?
17.11.2017 | University of North Carolina Health Care

nachricht Microbial resident enables beetles to feed on a leafy diet
17.11.2017 | Max-Planck-Institut für chemische Ökologie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

Im Focus: Wrinkles give heat a jolt in pillared graphene

Rice University researchers test 3-D carbon nanostructures' thermal transport abilities

Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

NASA detects solar flare pulses at Sun and Earth

17.11.2017 | Physics and Astronomy

NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures

17.11.2017 | Health and Medicine

The importance of biodiversity in forests could increase due to climate change

17.11.2017 | Studies and Analyses

VideoLinks
B2B-VideoLinks
More VideoLinks >>>