Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Human RecQ helicases, homologous recombination and genomic instability

19.11.2007
Two independent papers in the December 1st issue of G&D detail how human RecQ helicases regulate homologous recombination and protect genome stability.

The human RecQ family of helicases consists of 5 members: WRN, BLM, RECQL4, RECQL1 and RECQL5. These enzymes help to unwind DNA so to facilitate replication, transcription and DNA repair. Mutations in BLM, WRN and RECQ4 cause the cancer-predisposition syndromes Bloom’s Syndrome, Werner’s Syndrome and Rothmund-Thomson Syndrome, respectively. Interestingly, these cancer-prone genetic conditions are associated with defects in the DNA repair pathway of homologous recombination (HR).

Dr. Alexander Mazin (Drexel University College of Medicine) and colleagues focused their research on the function of the Bloom’s syndrome helicase, BLM. They found that BLM has differential roles in regulating HR: depending upon the stage of its involvement, BLM can either promote or inhibit HR – leading the authors to the surprising conclusion that the “combination of opposing activities gives BLM an important leverage in regulation of HR.”

In a separate paper, Drs. Guangbin Luo (Case Western Reserve Univeristy) and Patrick Sung (Yale University School of Medicine) and their colleagues demonstrate that another member of the human RecQ family, RECQL5, can also interfere with HR, by disrupting a particular step (formation of the Rad51 presynaptic filament) in the pathway. Dr. Sung emphasizes that “These results elucidate hoe RECQL5 proetin helps avoid deleterious chromosome rearrangements that can cause tumorigenesis.”

... more about:
»BLM »RecQ »helicase »recombination

Taken together, these papers lend new insight into the molecular function of human RecQ helicases in protecting genome stability and preventing tumorigenesis.

Heather Cosel | EurekAlert!
Further information:
http://www.cshl.edu

Further reports about: BLM RecQ helicase recombination

More articles from Life Sciences:

nachricht Research team of the HAW Hamburg reanimated ancestral microbe from the depth of the earth
01.03.2017 | Hochschule für Angewandte Wissenschaften Hamburg

nachricht Researchers Imitate Molecular Crowding in Cells
01.03.2017 | Universität Basel

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

Im Focus: Safe glide at total engine failure with ELA-inside

On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded after a glide flight with an Airbus A320 in ditching on the Hudson River. All 155 people on board were saved.

On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded...

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

A better way to measure the stiffness of cancer cells

01.03.2017 | Health and Medicine

Exploring the mysteries of supercooled water

01.03.2017 | Physics and Astronomy

Research team of the HAW Hamburg reanimated ancestral microbe from the depth of the earth

01.03.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>