Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Human RecQ helicases, homologous recombination and genomic instability

Two independent papers in the December 1st issue of G&D detail how human RecQ helicases regulate homologous recombination and protect genome stability.

The human RecQ family of helicases consists of 5 members: WRN, BLM, RECQL4, RECQL1 and RECQL5. These enzymes help to unwind DNA so to facilitate replication, transcription and DNA repair. Mutations in BLM, WRN and RECQ4 cause the cancer-predisposition syndromes Bloom’s Syndrome, Werner’s Syndrome and Rothmund-Thomson Syndrome, respectively. Interestingly, these cancer-prone genetic conditions are associated with defects in the DNA repair pathway of homologous recombination (HR).

Dr. Alexander Mazin (Drexel University College of Medicine) and colleagues focused their research on the function of the Bloom’s syndrome helicase, BLM. They found that BLM has differential roles in regulating HR: depending upon the stage of its involvement, BLM can either promote or inhibit HR – leading the authors to the surprising conclusion that the “combination of opposing activities gives BLM an important leverage in regulation of HR.”

In a separate paper, Drs. Guangbin Luo (Case Western Reserve Univeristy) and Patrick Sung (Yale University School of Medicine) and their colleagues demonstrate that another member of the human RecQ family, RECQL5, can also interfere with HR, by disrupting a particular step (formation of the Rad51 presynaptic filament) in the pathway. Dr. Sung emphasizes that “These results elucidate hoe RECQL5 proetin helps avoid deleterious chromosome rearrangements that can cause tumorigenesis.”

... more about:
»BLM »RecQ »helicase »recombination

Taken together, these papers lend new insight into the molecular function of human RecQ helicases in protecting genome stability and preventing tumorigenesis.

Heather Cosel | EurekAlert!
Further information:

Further reports about: BLM RecQ helicase recombination

More articles from Life Sciences:

nachricht ‘Farming’ bacteria to boost growth in the oceans
24.10.2016 | Max-Planck-Institut für marine Mikrobiologie

nachricht Calcium Induces Chronic Lung Infections
24.10.2016 | Universität Basel

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Light-driven atomic rotations excite magnetic waves

Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion

Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Oasis of life in the ice-covered central Arctic

24.10.2016 | Earth Sciences

‘Farming’ bacteria to boost growth in the oceans

24.10.2016 | Life Sciences

Light-driven atomic rotations excite magnetic waves

24.10.2016 | Physics and Astronomy

More VideoLinks >>>