Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Tiny chemical change in horse herpes virus can have lethal effect

12.11.2007
Sometimes, a small change can make a big difference. Such is the case with the horse herpes virus: A change in just one amino acid can make all the difference between triggering a cold or a life-threatening neurological disorder.

Cornell microbiologists have shown that a single amino acid variation in an enzyme that is part of the DNA copying process of equid herpesvirus type 1 (EHV-1) creates a different type of EHV-1, which causes the neurological disorders in horses. Both types of EHV-1 can also cause abortions.

The researchers' paper is published in the Nov. 9 issue of PLoS Pathogens, published by the Public Library of Science.

The horse herpes virus, a close relative of the chickenpox virus in humans, lives in horses' nostrils and is commonly spread by droplets in the air. And horses remain infected for life. Recently, veterinarians noticed a rise in outbreaks of the neurological form of EHV-1, which can devastate entire herds. Close to one-third of horses that develop the neurological disease end up dying or being euthanized.

... more about:
»EHV-1 »Herpes »Virus »horse »neurological

"There are apparently two distinct pathotypes of EHV-1 out there, and one is more likely than the other to cause the neurological disease. This study provides the ultimate proof," said Klaus Osterrieder, the paper's senior author who is professor of virology in the Department of Microbiology and Immunology in Cornell's College of Veterinary Medicine. Laura Goodman, who was a graduate student in the Osterrieder laboratory and is now a postdoctoral associate at Cornell's Baker Institute for Animal Health, is the paper's lead author.

After cloning the genome of the virus obtained from a mare that had both lost a fetus and developed neurological symptoms, the researchers then altered one amino acid in the viral enzyme known as DNA polymerase and rendered the virus unable to cause neurological disease. The amino acid change reduced levels of the virus in the horse's bloodstream, and lower levels of the virus reached the central nervous system. The mutation also made the virus more susceptible to antiviral drugs. The researchers believe the reduced replication and levels of virus in the blood may be why one form of the virus does not cause neurological disorders.

"The two pathotypes replicate to similar levels in the horse's nose and spread to other horses with similar efficiency, so interventions should be equally rigorous for all infections," said Osterrieder.

The fact that EHV-1 is a virus and, thus, does not respond to antibiotics underscores the need for prevention, which includes limiting contact and using separate feeders for infected horses. Also, handlers should be careful not to transfer the virus with their clothes, shoes, hands and gear. While vaccines are available that create an immune response against the EHV-1 respiratory disease, no vaccine is currently known to efficiently protect horses against the neurological disease. Only a few vaccines were shown to protect against abortion.

The researchers postulate that herpes viruses evolve toward strains that produce less disease, so they think that the more virulent neurological strain is older than the milder type of EHV-1.

Krishna Ramanujan | EurekAlert!
Further information:
http://www.cornell.edu

Further reports about: EHV-1 Herpes Virus horse neurological

More articles from Life Sciences:

nachricht Enduring cold temperatures alters fat cell epigenetics
19.04.2018 | University of Tokyo

nachricht Full of hot air and proud of it
18.04.2018 | University of Pittsburgh

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Writing and deleting magnets with lasers

Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.

Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...

Im Focus: Gamma-ray flashes from plasma filaments

Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.

The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...

Im Focus: Basel researchers succeed in cultivating cartilage from stem cells

Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.

Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...

Im Focus: Like a wedge in a hinge

Researchers lay groundwork to tailor drugs for new targets in cancer therapy

In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...

Im Focus: The Future of Ultrafast Solid-State Physics

In an article that appears in the journal “Review of Modern Physics”, researchers at the Laboratory for Attosecond Physics (LAP) assess the current state of the field of ultrafast physics and consider its implications for future technologies.

Physicists can now control light in both time and space with hitherto unimagined precision. This is particularly true for the ability to generate ultrashort...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

IWOLIA: A conference bringing together German Industrie 4.0 and French Industrie du Futur

09.04.2018 | Event News

 
Latest News

Diamond-like carbon is formed differently to what was believed -- machine learning enables development of new model

19.04.2018 | Materials Sciences

Electromagnetic wizardry: Wireless power transfer enhanced by backward signal

19.04.2018 | Physics and Astronomy

Ultrafast electron oscillation and dephasing monitored by attosecond light source

19.04.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>