The current HAART therapy against HIV uses a combination of several different drugs, which decreases the probability of simultaneous development of resistance against different drugs. Team of Slovenian undergraduate students from the University of Ljubljana together with their mentors from the National institute of chemistry of Slovenia (NIC) developed a new strategy of antiviral defense that is not breached by viral mutations. Their approach, which the students half-jokingly called »Virotrap« is based on detecting viral function rather than specific sequences.
Viral function such as attachment to the host cells triggers a cellular response which can either activate the antiviral defence or lead to a destruction of infected cells to prevent spread of the infection. The effect of viral mutations is thus avoided since mutations that cause the loss of the function also render the virus harmless. Leader of the team, prof. Roman Jerala from the NIC says: “The same approach could be implemented for defence against other viral infections. We think we can design the system that can be activated also by other HIV-specific functions”. Animal experiments will be needed to test the therapeutic potentials of this system, which would be applied as gene therapy but results on cells look very promising.
Team competed with this project at the recent international Genetically Engineered Machines competition iGEM) held at the Massachussetts Institute of Technology (MIT) in the first weekend of November and was among the 56 teams selected among the six finalists and won the fist prize among the projects on the topic of Health and Medicine. Other interesting projects in this competition included artificial blood made of bacteria by the Berkeley team (Bactoblood), anticancer therapy based on the siRNA by the Princeton team, Infector detector by the Imperial College team, multicellular organisms based on bacteria by the Paris team and many others.
Brigita Pirc | alfa
Designer cells: artificial enzyme can activate a gene switch
22.05.2018 | Universität Basel
Flow of cerebrospinal fluid regulates neural stem cell division
22.05.2018 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.
The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
22.05.2018 | Life Sciences
22.05.2018 | Earth Sciences
22.05.2018 | Trade Fair News