Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Stressed intestine can give rise to food allergy

19.04.2002


The intestines of mice which have been subjected to stress, overreact to certain nutritional substances. PhD biologist Annette van Kalkeren from the University of Amsterdam has investigated the relationship between stress and the occurrence of food allergies and various intestinal disorders.



The biologist investigated the reaction of pieces of mouse intestine to egg albumin, a substance found in eggs. Just like humans, mice can become allergic to the substance. However, mice only become allergic if they are injected with the substance and not as a result of eating it. The aim of the study was to investigate whether mice could become allergic to egg albumin if they ate it whilst stressed. The intestinal wall becomes more permeable under stressful conditions. Harmful substances penetrate the permeable intestinal wall where they then cause a panic response by the immune system. That could be the start of an allergy. The intestines of allergic mice demonstrate, just as in humans, a diarrhoea response if they come into contact with egg albumin. The cells in the intestinal wall then excrete salt and water. Research revealed that the intestines of non-allergic mice also sometimes exhibited a localised diarrhoea reaction if they came into contact with egg albumin. However, the localised diarrhoea occurred much more frequently in the intestines of mice which had been deliberately stressed prior to the experiment. Furthermore, the intestines of mice subjected to prolonged stress were much more sensitive for neurotransmitters from nerve cells which cause diarrhoea and the contraction of the intestinal muscles. Annette van Kalkeren used a systematic treatment to stress the mice. The mice had to spend several hours in a narrow tube. Sometimes they were also placed in a cold environment. A number of mice were subjected to a maximum of three days of social isolation. Some also had to swim for three minutes. The excretion of salt and water is a response of the intestines to wash out unwanted substances. However, the intestinal wall is then much more permeable to allergens. Whether or not this has a function is not known. The Amsterdam researcher suspects that a higher permeability promotes the immune response. Antigens from the body can then get closer to the intestinal content. The defence of the body is then pushed forward so to speak. However, during chronic stress the defence of the body is weakened and allergens can penetrate to deep into the body. Food allergies and various intestinal diseases, such as Crohn`s disease, ulcerative colitus and irritable bowel syndrome can in part be caused or enhanced by chronic stress. The mechanism behind this has yet to be elucidated.

Michel Philippens | alphagalileo

More articles from Life Sciences:

nachricht Nesting aids make agricultural fields attractive for bees
20.07.2017 | Julius-Maximilians-Universität Würzburg

nachricht The Kitchen Sponge – Breeding Ground for Germs
20.07.2017 | Hochschule Furtwangen

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

Im Focus: The proton precisely weighted

What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.

To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...

Im Focus: On the way to a biological alternative

A bacterial enzyme enables reactions that open up alternatives to key industrial chemical processes

The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....

Im Focus: The 1 trillion tonne iceberg

Larsen C Ice Shelf rift finally breaks through

A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...

Im Focus: Laser-cooled ions contribute to better understanding of friction

Physics supports biology: Researchers from PTB have developed a model system to investigate friction phenomena with atomic precision

Friction: what you want from car brakes, otherwise rather a nuisance. In any case, it is useful to know as precisely as possible how friction phenomena arise –...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

The technology with a feel for feelings

12.07.2017 | Event News

Leipzig HTP-Forum discusses "hydrothermal processes" as a key technology for a biobased economy

12.07.2017 | Event News

 
Latest News

Researchers create new technique for manipulating polarization of terahertz radiation

20.07.2017 | Information Technology

High-tech sensing illuminates concrete stress testing

20.07.2017 | Materials Sciences

First direct observation and measurement of ultra-fast moving vortices in superconductors

20.07.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>