Yet biofilms also have equal potential for good behaviour, in particular as agents of self-purification in streams and rivers, waste and pollution treatment, or generation of carbon-neutral electricity. These critical properties are derived from the existence of the protective slimy matrix within which members of the community live, preventing attack from both the immune system and antibiotics, but at the same time shielding them from toxic contaminants while breaking down waste or effluent.
The study of biofilms has emerged over the last three decades in various disciplines such as biotechnology, bioengineering or infectious disease research, leading to rapid progress, but also fragmentation and duplication of effort. The European Science Foundation (ESF) has stepped in to unite Europe's effort and bring together scientists with the required skills in relevant fields such as genetics, molecular biology, microscopy, medical microbiology, environmental science and ecology.
The programme began with an Exploratory Workshop in September 2007, leading to a proposal for a new body to coordinate activities, the European Biofilm Net (EBN). The ESF workshop highlighted the huge potential and importance of biofilms, and also drew attention to exciting work unravelling the complex genetic and cellular interactions within these small yet teeming communities.
As the ESF Biofilm workshop's convenor Tom J. Battin, from the University of Vienna, pointed out, biofilms are involved in most chronic infections, including killers such as cystic fibrosis, and endocarditis in the heart. In cystic fibrosis, excess mucus production in the airways gives sanctuary to bacteria such as Pseudomonas aeruginosa, which actually mop up the dead carcasses of white blood cells sent by the immune system, enabling them to construct their protective biofilm coat.
In this case the immune system is the architect of its own problems, helping create the shield used to repel its own agents, as well as resisting antibiotics. Indeed resistance against antibiotics is itself one of the biggest problems of all associated with biofilms, Battin noted.
"This becomes particularly dramatic for endocarditis patients, as was outlined at the workshop by Annette Moter from the Charite in Berlin," said Battin. Endocarditis is a rare but serious disease in which one of the four heart valves, the heart lining, or heart muscle, are infected by a bacterial biofilm, often comprising streptococci, and become inflamed. As the biofilms are resistant to antibiotics and the immune system's white blood cells, very often the only remedy is surgery, to replace a damaged valve, which can itself cause problems. The hope is that greater understanding will yield new drugs that reach the infected heart valve and break up the biofilm.
As Battin pointed out, biofilms can pose a big problem in large-scale water treatment plants, and yet for the very same reasons can play a positive role in the very same process, breaking down contaminants in waste and natural waters, for example. Further research will help ensure that the positive role is accentuated, while avoiding the problems.
The ESF workshop also highlighted greater understanding of the complex interactions within biofilms, which often comprise not just one species of bacteria, but a whole host of different micro-organisms, including archaea, protozoa, fungi, and even tiny metazoa actually comprising multiple cells. Many biofilms are in fact complete micro-ecosystems, within which there is competition as well as cooperation, and unraveling the interactions will reveal valuable insights into how these evolved.
Yet there is also great excitement about an emerging application that could have some potential for green energy production - the use of biofilms to power microbial fuel cells whose fuel could be wastewater, as outlined at the ESF workshop by Cristian Picioreanu, Delft University of Technology. This exploits the ability of bacteria to transfer electrons to metals, which can be the cathode of a fuel cell, via the minute tentacles called phili extending from their surface.
The ESF Workshop, "Valuing Biofilm Services: the Beauty and the Beast", was held 19-22 September at the interuniversity research center WasserCluster Lunz, Austria. This is being followed by a proposal for the EBN, with the specific objectives of developing both laboratory and computational techniques, while integrating relevant fields such as system biology or ecology and evolution, to create the interdisciplinary platform for a new era of biofilm research.
Each year, ESF supports approximately 50 Exploratory Workshops across all scientific domains. These small, interactive group sessions are aimed at opening up new directions in research to explore new fields with a potential impact on developments in science.
Thomas Lau | alfa
The gene of autumn colours
27.10.2016 | Hokkaido University
Polymer scaffolds build a better pill to swallow
27.10.2016 | The Agency for Science, Technology and Research (A*STAR)
Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.
This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...
Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion
Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
27.10.2016 | Life Sciences
27.10.2016 | Life Sciences
26.10.2016 | Power and Electrical Engineering