Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Decoding effects of toxins on embryo development

25.10.2007
Changes in gene expression patterns in zebrafish embryos resulting from exposure to environmental toxins can identify the individual toxins at work, according to research published in the online open access journal Genome Biology.

The genetic response of zebrafish to each toxin can be read like a barcode, offering researchers a potential method for identifying the effects of the toxin on developing vertebrate embryos.

Zebrafish embryos were exposed to eleven common pollutants, including cadmium, mercury and arsenic, by a team led by Uwe Strähle at the Institute of Toxicology and Genetics, Karlsruhe, Germany. The team monitored changes in gene-expression profiles in order to predict the chemical that the embryo had been exposed to; the results were clear-cut for 10 out of 11 toxins.

Zebrafish have previously found a role in toxicology tests, for example in testing sewage for the presence of toxins. However, these previous tests involved looking at adult fish or embryos. The new method developed by Strähle and colleagues does distinguish individual genetic barcodes of chemicals and will help cope with the high demand from regulators and industry for reliable methods needed to evaluate the developmental toxicity of pharmaceuticals, industrial chemicals and waste products. The research may prove valuable for initiatives such as the European Union Registration, Evaluation and Authorisation of Chemicals programme (REACH) which was set up to improve the protection of human health and the environment through the better and earlier identification of the intrinsic properties of chemical substances.

... more about:
»Development »Embryo »Toxin

"Zebrafish embryos offer a cheap and ethically acceptable vertebrate model that will not only be useful in the toxicological assessment of the tens of thousands of compounds to be tested under the REACH programme but can also help to evaluate the developmental toxicity of novel compounds at an early stage of drug development," says Strähle.

This new work provides the basis for the development of large-scale systematic methods for identifying the potential of chemicals.

Charlotte Webber | alfa
Further information:
http://genomebiology.com/
http://www.biomedcentral.com

Further reports about: Development Embryo Toxin

More articles from Life Sciences:

nachricht At last, butterflies get a bigger, better evolutionary tree
16.02.2018 | Florida Museum of Natural History

nachricht New treatment strategies for chronic kidney disease from the animal kingdom
16.02.2018 | Veterinärmedizinische Universität Wien

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

Im Focus: Interference as a new method for cooling quantum devices

Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters

Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...

Im Focus: Autonomous 3D scanner supports individual manufacturing processes

Let’s say the armrest is broken in your vintage car. As things stand, you would need a lot of luck and persistence to find the right spare part. But in the world of Industrie 4.0 and production with batch sizes of one, you can simply scan the armrest and print it out. This is made possible by the first ever 3D scanner capable of working autonomously and in real time. The autonomous scanning system will be on display at the Hannover Messe Preview on February 6 and at the Hannover Messe proper from April 23 to 27, 2018 (Hall 6, Booth A30).

Part of the charm of vintage cars is that they stopped making them long ago, so it is special when you do see one out on the roads. If something breaks or...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Fingerprints of quantum entanglement

16.02.2018 | Information Technology

'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers

16.02.2018 | Health and Medicine

Hubble sees Neptune's mysterious shrinking storm

16.02.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>