Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Decoding effects of toxins on embryo development

25.10.2007
Changes in gene expression patterns in zebrafish embryos resulting from exposure to environmental toxins can identify the individual toxins at work, according to research published in the online open access journal Genome Biology.

The genetic response of zebrafish to each toxin can be read like a barcode, offering researchers a potential method for identifying the effects of the toxin on developing vertebrate embryos.

Zebrafish embryos were exposed to eleven common pollutants, including cadmium, mercury and arsenic, by a team led by Uwe Strähle at the Institute of Toxicology and Genetics, Karlsruhe, Germany. The team monitored changes in gene-expression profiles in order to predict the chemical that the embryo had been exposed to; the results were clear-cut for 10 out of 11 toxins.

Zebrafish have previously found a role in toxicology tests, for example in testing sewage for the presence of toxins. However, these previous tests involved looking at adult fish or embryos. The new method developed by Strähle and colleagues does distinguish individual genetic barcodes of chemicals and will help cope with the high demand from regulators and industry for reliable methods needed to evaluate the developmental toxicity of pharmaceuticals, industrial chemicals and waste products. The research may prove valuable for initiatives such as the European Union Registration, Evaluation and Authorisation of Chemicals programme (REACH) which was set up to improve the protection of human health and the environment through the better and earlier identification of the intrinsic properties of chemical substances.

... more about:
»Development »Embryo »Toxin

"Zebrafish embryos offer a cheap and ethically acceptable vertebrate model that will not only be useful in the toxicological assessment of the tens of thousands of compounds to be tested under the REACH programme but can also help to evaluate the developmental toxicity of novel compounds at an early stage of drug development," says Strähle.

This new work provides the basis for the development of large-scale systematic methods for identifying the potential of chemicals.

Charlotte Webber | alfa
Further information:
http://genomebiology.com/
http://www.biomedcentral.com

Further reports about: Development Embryo Toxin

More articles from Life Sciences:

nachricht Building a brain, cell by cell: Researchers make a mini neuron network (of two)
23.05.2018 | Institute of Industrial Science, The University of Tokyo

nachricht Research reveals how order first appears in liquid crystals
23.05.2018 | Brown University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Research reveals how order first appears in liquid crystals

23.05.2018 | Life Sciences

Space-like gravity weakens biochemical signals in muscle formation

23.05.2018 | Life Sciences

NIST puts the optical microscope under the microscope to achieve atomic accuracy

23.05.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>