Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Rutgers biomaterial debuts in clinical trials of new stent

22.10.2007
A revolutionary, new biomaterial, developed at the New Jersey Center for Biomaterials (NJCBM) at Rutgers University, has moved from the lab bench to field testing in record time. This achievement, a product of a breakthrough methodology in biomaterials discovery, is the enabling technology behind a coronary stent undergoing its first-in-human clinical trial in Germany and in Brazil.

Stents are tiny tubes inserted into diseased arteries to keep them open. The stent being tested, designed by REVA Medical Inc. of San Diego, is intended to act as a temporary scaffold to support the blood vessel during the healing process and maintain blood flow. It subsequently dissolves, leaving the patient free of any permanent implant.

Rutgers’ Joachim Kohn is reporting on his new combinatorial biomaterials discovery process and the promise it holds for the medical device industry during TCT 2007 (Transcatheter Cardiovascular Therapeutics), the world's premier conference on interventional cardiology, which begins Saturday, Oct. 20 in Washington, D.C. Also reporting at the conference, Dr. Eberhard Grube of the HELIOS Heart Center in Germany describes the initial clinical experience from the RESORB trial that is evaluating the stent’s safety in approximately 30 patients at multiple sites in Germany and Brazil.

Fully degradable coronary stents have been explored for more than 20 years. But, according to Kohn, no clinically useful products could be developed, in part, because of the lack of polymers that could meet the extremely demanding performance requirements. Kohn and his team addressed this problem by developing a library of degradable polymers comprising 10,000 theoretically possible compositions and applying combinatorial methods to identify the best possible biomaterial. The resulting material was selected for use in combination with REVA’s novel stent design.

... more about:
»Biomaterial »Design »Kohn’s »Polymer »Stent

“We’ve applied novel design and advanced biomaterials solutions to create a significant advance in stent technology,” said Dr. Robert Schultz, REVA’s president. “This approach has allowed for us to bring it to the clinical stage quickly.”

“Our unconventional discovery process integrates combinatorial polymer libraries, high-throughput testing and computational modeling. This results in a much faster path to prototype development and a reduction in the cost and risk associated with the use of new, proprietary biomaterials,” said Kohn, a Board of Governors Professor who directs the New Jersey Center for Biomaterials at Rutgers.

Michael J. Pazzani, vice president for research and graduate and professional education at Rutgers, spoke of the impact of Kohn’s work on the medical device industry. In addition to REVA, Rutgers has licensed the portfolio of Kohn’s patents to several other companies. “One licensee was able to obtain FDA clearance for a new hernia repair device using one of Kohn’s polymers on a three-year track from concept to FDA market clearance,” Pazzani said. “Another is working with Kohn's combinatorial discovery process to identify an ideal polymer for their ophthalmic drug delivery device.”

The significance of Kohn’s work is related to its general applicability to many different biomaterials design challenges as evidenced by the diversity of products being commercialized using this discovery process.

The scientific foundations of the new biomaterials discovery process are being developed with support to the New Jersey Center for Biomaterials and the Kohn Laboratory from the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health.

In collaboration with REVA, Kohn and his colleagues developed a polymer that is exceptionally strong and highly suitable for stent applications. In addition, the material was designed to be radio-opaque so it is X-ray visible, a property critical to the proper placement of the stent in the artery. It is also biodegradable and biocompatible.

Pazzani said that reaching the clinical trial stage is an accomplishment for the university and a great source of pride. “This is a major achievement for our state, a success story for our Office of Corporate Liaison and Technology Transfer,” he said, and, Pazzani added, “it is significant validation for the work of Rutgers scientists.”

Joseph Blumberg | EurekAlert!
Further information:
http://www.rutgers.edu

Further reports about: Biomaterial Design Kohn’s Polymer Stent

More articles from Life Sciences:

nachricht Fine organic particles in the atmosphere are more often solid glass beads than liquid oil droplets
21.04.2017 | Max-Planck-Institut für Chemie

nachricht Study overturns seminal research about the developing nervous system
21.04.2017 | University of California - Los Angeles Health Sciences

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

Im Focus: Quantum-physical Model System

Computer-assisted methods aid Heidelberg physicists in reproducing experiment with ultracold atoms

Two researchers at Heidelberg University have developed a model system that enables a better understanding of the processes in a quantum-physical experiment...

Im Focus: Glacier bacteria’s contribution to carbon cycling

Glaciers might seem rather inhospitable environments. However, they are home to a diverse and vibrant microbial community. It’s becoming increasingly clear that they play a bigger role in the carbon cycle than previously thought.

A new study, now published in the journal Nature Geoscience, shows how microbial communities in melting glaciers contribute to the Earth’s carbon cycle, a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

New quantum liquid crystals may play role in future of computers

21.04.2017 | Physics and Astronomy

A promising target for kidney fibrosis

21.04.2017 | Health and Medicine

Light rays from a supernova bent by the curvature of space-time around a galaxy

21.04.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>