Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

In vitro models will minimize animal use in arthritis studies

22.10.2007
MU researchers have developed a model that mimics actual joints

It’s hard to think of scientists in laboratories working toward solutions for medical problems without mice or other laboratory animals, but animals’ roles in at least one major research laboratory may soon be minimal.

Researchers at the University of Missouri-Columbia's Comparative Orthopaedic Laboratory (COL) have developed an in vitro model using small sections of joint capsule and cartilage typically discarded that mimics arthritic joints. This "joint in a test tube" model can be used to investigate causes and mechanisms for the development and progression of arthritis and to screen new treatments such as pharmaceuticals. The MU research team which developed this model has shown that the results have valid and direct clinical implications for arthritis in dogs and humans.

Often, clinical research is limited by patient numbers, accessibility to appropriate samples and ethical considerations. Using in vitro models eliminates some of these barriers and allows researchers to better understand of the disease’s development, characteristics and responses to various injuries, treatments and loads. The in vitro model acts similar to an actual joint with the same histological, biochemical and molecular changes.

... more about:
»Animal »Arthritis »Researchers »VITRO »allow

“These in vitro models will allow us to perform our research without using animals while still accurately mimicking situations in real life,” said James Cook, professor of veterinary medicine and surgery and the William C. Allen Endowed Scholar for Orthopaedic Research. “We can screen new drugs for arthritis in a more efficient and cost-effective way such that real progress is achieved more quickly.”

The in vitro models allow for all of the tissue in a normal joint to be "grown" together such that the different types of tissues can "communicate" as they do in the actual joint. COL researchers have shown that this system maintains the tissues' appearance, composition, and function so that they react to health and disease as they would in real life. The system then allows drugs, nutritional supplements and even exercise regimens to be tested on the in vitro model.

For example, scientists can determine the effects of pressure to the joints after running or walking using a bioreactor, a device which loads the tissues in the "test tube" environment. Using this new model, MU researchers will unlock clues, on a molecular level, as to why recovery is important in healthy athletes as well as people with arthritis.

“Using the joints in the test tubes will allow for greater flexibility when studying arthritis,” Cook said. “We can test literally hundreds of different loads on joints in a single day and show results in real time. It is strengthening our research as we are able to explain data on a molecular level and then translate it to what happens to people and pets that struggle with arthritis every day.

“These in vitro models also provide a much safer mechanism for investigating new drugs and therapies. If severe side effects occur, all we have do is assess what has happened to the tissues rather than trying to treat a laboratory animal or a patient with an adverse reaction.”

Christian Basi | EurekAlert!
Further information:
http://www.missouri.edu

Further reports about: Animal Arthritis Researchers VITRO allow

More articles from Life Sciences:

nachricht More genes are active in high-performance maize
19.01.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht How plants see light
19.01.2018 | Albert-Ludwigs-Universität Freiburg im Breisgau

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Let the good tubes roll

19.01.2018 | Materials Sciences

How cancer metastasis happens: Researchers reveal a key mechanism

19.01.2018 | Health and Medicine

Meteoritic stardust unlocks timing of supernova dust formation

19.01.2018 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>