Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


In vitro models will minimize animal use in arthritis studies

MU researchers have developed a model that mimics actual joints

It’s hard to think of scientists in laboratories working toward solutions for medical problems without mice or other laboratory animals, but animals’ roles in at least one major research laboratory may soon be minimal.

Researchers at the University of Missouri-Columbia's Comparative Orthopaedic Laboratory (COL) have developed an in vitro model using small sections of joint capsule and cartilage typically discarded that mimics arthritic joints. This "joint in a test tube" model can be used to investigate causes and mechanisms for the development and progression of arthritis and to screen new treatments such as pharmaceuticals. The MU research team which developed this model has shown that the results have valid and direct clinical implications for arthritis in dogs and humans.

Often, clinical research is limited by patient numbers, accessibility to appropriate samples and ethical considerations. Using in vitro models eliminates some of these barriers and allows researchers to better understand of the disease’s development, characteristics and responses to various injuries, treatments and loads. The in vitro model acts similar to an actual joint with the same histological, biochemical and molecular changes.

... more about:
»Animal »Arthritis »Researchers »VITRO »allow

“These in vitro models will allow us to perform our research without using animals while still accurately mimicking situations in real life,” said James Cook, professor of veterinary medicine and surgery and the William C. Allen Endowed Scholar for Orthopaedic Research. “We can screen new drugs for arthritis in a more efficient and cost-effective way such that real progress is achieved more quickly.”

The in vitro models allow for all of the tissue in a normal joint to be "grown" together such that the different types of tissues can "communicate" as they do in the actual joint. COL researchers have shown that this system maintains the tissues' appearance, composition, and function so that they react to health and disease as they would in real life. The system then allows drugs, nutritional supplements and even exercise regimens to be tested on the in vitro model.

For example, scientists can determine the effects of pressure to the joints after running or walking using a bioreactor, a device which loads the tissues in the "test tube" environment. Using this new model, MU researchers will unlock clues, on a molecular level, as to why recovery is important in healthy athletes as well as people with arthritis.

“Using the joints in the test tubes will allow for greater flexibility when studying arthritis,” Cook said. “We can test literally hundreds of different loads on joints in a single day and show results in real time. It is strengthening our research as we are able to explain data on a molecular level and then translate it to what happens to people and pets that struggle with arthritis every day.

“These in vitro models also provide a much safer mechanism for investigating new drugs and therapies. If severe side effects occur, all we have do is assess what has happened to the tissues rather than trying to treat a laboratory animal or a patient with an adverse reaction.”

Christian Basi | EurekAlert!
Further information:

Further reports about: Animal Arthritis Researchers VITRO allow

More articles from Life Sciences:

nachricht Novel mechanisms of action discovered for the skin cancer medication Imiquimod
21.10.2016 | Technische Universität München

nachricht Second research flight into zero gravity
21.10.2016 | Universität Zürich

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Resolving the mystery of preeclampsia

21.10.2016 | Health and Medicine

Stanford researchers create new special-purpose computer that may someday save us billions

21.10.2016 | Information Technology

From ancient fossils to future cars

21.10.2016 | Materials Sciences

More VideoLinks >>>