Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New virus drug will have to shoot at moving targets

19.10.2007
The reproduction of the deadly hepatitis B virus is dependent on the mobility of one of the virus's RNAs. This is shown by Katja Petzold and Jürgen Schleucher, Umeå University, Sweden, in an article in the latest issue of the journal Nucleic Acids Research.

More than 300 million people all over the world are infected by hepatitis B virus (HBV), and there are 2 million deaths per year. The Umeå researchers have studied the mobility of the virus's RNA, a property that is necessary for HBV to reproduce. Besides Jürgen Schleucher and Katja Petzold, Karin Kidd-Ljunggren of Lund University in Sweden and Sybren Wijmenga of Nijmegen University in Holland are co-authors of the article.

The structures of proteins and nucleic acids are usually presented as still images. However, the molecules' functions or interactions with drugs are dependent on structural changes, and it is possible to reach only indirect conclusions about these on the basis of still images. Nuclear Magnetic Resonance (NMR) is the only technology that enables studies of movements in specific parts of molecules. With the aid of NMR, the relationship between the movement and function of molecules has been mapped for many proteins, but only for a few nucleic acids. This is unfortunate, especially because several new classes of RNA with regulatory functions have recently been discovered. This means that RNA is now regarded to an even greater extent as an active regulator of cellular events, not merely a passive messenger for information.

When new HBV particles are formed in infected cells, the virus must translate RNA to DNA, a process that is called reverse transcription. It starts with the virus enzyme reverse transcriptase binding to a strongly conserved RNA structure in the virus. The authors found that fully conserved nucleotides (the building blocks of RNA) in this RNA evince striking patterns of mobility. This indicates that these nucleotides in the free RNA temporarily visit the structures that they use in complexes with reverse transcriptases, and that their mobility facilitates binding. This means that drugs directed toward the hepatitis virus RNA need to bind to a moving target.

... more about:
»Hepatitis »MOVING »Mobility »RNA »binding

These detailed findings are based on the first application of a new NMR method that was developed at Umeå University. The new method enables studies of movements in the bindings in the RNA molecule that give it its form. The method can also be used for complex bindings between drug candidates and proteins or nucleic acids in order to elucidate the stabilizing forces at the atomic level. Therefore, this can be a key tool in biotechnology and the discovery of new drugs. The research team is now moving on to computer simulations to produce images of the movements in an RNA.

Reference: Petzold et al., Conserved nucleotides in an RNA essential for hepatitis B virus replication show distinct mobility patterns. Nucleic Acids Research, doi:10.1093/nar/gkm774

For more information, please contact Katja Petzold, Department of Medicinal Chemistry and Biophysics at e-mail katja.petzold@medchem.umu.se or phone:

+46-90 786 97 19.

Pressofficer Bertil Born; bertil.born@adm.umu.se; +46-703414 303

Bertil Born | idw
Further information:
http://www.vr.se

Further reports about: Hepatitis MOVING Mobility RNA binding

More articles from Life Sciences:

nachricht Researchers identify potentially druggable mutant p53 proteins that promote cancer growth
09.12.2016 | Cold Spring Harbor Laboratory

nachricht Plant-based substance boosts eyelash growth
09.12.2016 | Fraunhofer-Institut für Angewandte Polymerforschung IAP

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>