Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New virus drug will have to shoot at moving targets

19.10.2007
The reproduction of the deadly hepatitis B virus is dependent on the mobility of one of the virus's RNAs. This is shown by Katja Petzold and Jürgen Schleucher, Umeå University, Sweden, in an article in the latest issue of the journal Nucleic Acids Research.

More than 300 million people all over the world are infected by hepatitis B virus (HBV), and there are 2 million deaths per year. The Umeå researchers have studied the mobility of the virus's RNA, a property that is necessary for HBV to reproduce. Besides Jürgen Schleucher and Katja Petzold, Karin Kidd-Ljunggren of Lund University in Sweden and Sybren Wijmenga of Nijmegen University in Holland are co-authors of the article.

The structures of proteins and nucleic acids are usually presented as still images. However, the molecules' functions or interactions with drugs are dependent on structural changes, and it is possible to reach only indirect conclusions about these on the basis of still images. Nuclear Magnetic Resonance (NMR) is the only technology that enables studies of movements in specific parts of molecules. With the aid of NMR, the relationship between the movement and function of molecules has been mapped for many proteins, but only for a few nucleic acids. This is unfortunate, especially because several new classes of RNA with regulatory functions have recently been discovered. This means that RNA is now regarded to an even greater extent as an active regulator of cellular events, not merely a passive messenger for information.

When new HBV particles are formed in infected cells, the virus must translate RNA to DNA, a process that is called reverse transcription. It starts with the virus enzyme reverse transcriptase binding to a strongly conserved RNA structure in the virus. The authors found that fully conserved nucleotides (the building blocks of RNA) in this RNA evince striking patterns of mobility. This indicates that these nucleotides in the free RNA temporarily visit the structures that they use in complexes with reverse transcriptases, and that their mobility facilitates binding. This means that drugs directed toward the hepatitis virus RNA need to bind to a moving target.

... more about:
»Hepatitis »MOVING »Mobility »RNA »binding

These detailed findings are based on the first application of a new NMR method that was developed at Umeå University. The new method enables studies of movements in the bindings in the RNA molecule that give it its form. The method can also be used for complex bindings between drug candidates and proteins or nucleic acids in order to elucidate the stabilizing forces at the atomic level. Therefore, this can be a key tool in biotechnology and the discovery of new drugs. The research team is now moving on to computer simulations to produce images of the movements in an RNA.

Reference: Petzold et al., Conserved nucleotides in an RNA essential for hepatitis B virus replication show distinct mobility patterns. Nucleic Acids Research, doi:10.1093/nar/gkm774

For more information, please contact Katja Petzold, Department of Medicinal Chemistry and Biophysics at e-mail katja.petzold@medchem.umu.se or phone:

+46-90 786 97 19.

Pressofficer Bertil Born; bertil.born@adm.umu.se; +46-703414 303

Bertil Born | idw
Further information:
http://www.vr.se

Further reports about: Hepatitis MOVING Mobility RNA binding

More articles from Life Sciences:

nachricht Could this protein protect people against coronary artery disease?
17.11.2017 | University of North Carolina Health Care

nachricht Microbial resident enables beetles to feed on a leafy diet
17.11.2017 | Max-Planck-Institut für chemische Ökologie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

Im Focus: Wrinkles give heat a jolt in pillared graphene

Rice University researchers test 3-D carbon nanostructures' thermal transport abilities

Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

NASA detects solar flare pulses at Sun and Earth

17.11.2017 | Physics and Astronomy

NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures

17.11.2017 | Health and Medicine

The importance of biodiversity in forests could increase due to climate change

17.11.2017 | Studies and Analyses

VideoLinks
B2B-VideoLinks
More VideoLinks >>>