Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A previously unknown coupling between obesity and diabetes

17.10.2007
Obesity increases the risk of developing diabetes, but nobody knows the details of why this is the case. Researchers at the Sahlgrenska Academy in Sweden have now identified a protein that may play a role in increasing the risk. The discovery may in the long term lead to new methods of preventing type 2 diabetes.

Diabetes is a metabolic condition in which the body does not form sufficient quantities of insulin or in which the insulin that is formed does not have sufficient effect. The most common form of the disease is type 2 diabetes, which is the variant that adults can develop.

Most people who develop type 2 diabetes are overweight. Fat can accumulate in the muscles and liver of an obese person, leading to cell damage that in turn leads to a defect in the signalling from insulin. The result is an increase in the blood sugar level, and diabetes develops.

"The faulty storage of fat in the muscle cells interferes with the signal from the insulin that should stimulate increased absorption of sugar by the cells. The fat is stored in the cells in the form of fat droplets, and we have studied in detail how these are formed and how they grow. This has enabled us to show how the insulin signal is disrupted", says Professor Sven Olof Olofsson, director of the Wallenberg Laboratory at the Sahlgrenska Academy.

... more about:
»Diabetes »HDL-cholesterol »Insulin »Protein »droplets

The research project used several advanced microscopy techniques to study lipid droplets in cultured muscle cells. It became clear that the lipid droplets merged with each other inside the cell by a process that involved a protein known as "SNAP23". This protein has another, independent, function - that of passing the insulin signal onwards into the cell.

"It appears that the SNAP23 is being 'stolen' from the insulin signalling process when the cell starts to pack fat, and this causes the defect that subsequently leads to diabetes. If we can find out more about how this works in detail, we may be able to influence the process and protect patients from developing diabetes", says Pontus Boström, PhD student at the Sahlgrenska Academy.

Further research will be necessary before the results can be tested in patients.

The results will be published in the next issue of the journal Nature Cell Biology.

Journal: Nature Cell Biology
Article title: SNARE proteins mediate fusion between cytosolic lipid droplets with implications for insulin sensitivity

Authors: Pontus Boström, Linda Andersson, Mikale Rutberg, Jeanna Perman, Ulf Lidberg, Bengt R. Johansson, Julia Fernandez-Rodriguez, Tommy Nilsson, Jan Borén and Sven-Olof Olofsson.

For more information, contact: Professor Sven Olof Olofsson, telephone: +46 31 342 1956, e-mail: sven-olof.olofsson@wlab.gu.se Dr. Pontus Boström, telephone: +46 31 342 2947, e-mail: pontus.bostrom@wlab.gu.se

Elin Lindström Claessen | idw
Further information:
http://www.vr.se
http://www.nature.com/ncb/journal/vaop/ncurrent/full/ncb1648.html

Further reports about: Diabetes HDL-cholesterol Insulin Protein droplets

More articles from Life Sciences:

nachricht Single-stranded DNA and RNA origami go live
15.12.2017 | Wyss Institute for Biologically Inspired Engineering at Harvard

nachricht New antbird species discovered in Peru by LSU ornithologists
15.12.2017 | Louisiana State University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First-of-its-kind chemical oscillator offers new level of molecular control

DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.

Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Engineers program tiny robots to move, think like insects

15.12.2017 | Power and Electrical Engineering

One in 5 materials chemistry papers may be wrong, study suggests

15.12.2017 | Materials Sciences

New antbird species discovered in Peru by LSU ornithologists

15.12.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>