Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A previously unknown coupling between obesity and diabetes

17.10.2007
Obesity increases the risk of developing diabetes, but nobody knows the details of why this is the case. Researchers at the Sahlgrenska Academy in Sweden have now identified a protein that may play a role in increasing the risk. The discovery may in the long term lead to new methods of preventing type 2 diabetes.

Diabetes is a metabolic condition in which the body does not form sufficient quantities of insulin or in which the insulin that is formed does not have sufficient effect. The most common form of the disease is type 2 diabetes, which is the variant that adults can develop.

Most people who develop type 2 diabetes are overweight. Fat can accumulate in the muscles and liver of an obese person, leading to cell damage that in turn leads to a defect in the signalling from insulin. The result is an increase in the blood sugar level, and diabetes develops.

"The faulty storage of fat in the muscle cells interferes with the signal from the insulin that should stimulate increased absorption of sugar by the cells. The fat is stored in the cells in the form of fat droplets, and we have studied in detail how these are formed and how they grow. This has enabled us to show how the insulin signal is disrupted", says Professor Sven Olof Olofsson, director of the Wallenberg Laboratory at the Sahlgrenska Academy.

... more about:
»Diabetes »HDL-cholesterol »Insulin »Protein »droplets

The research project used several advanced microscopy techniques to study lipid droplets in cultured muscle cells. It became clear that the lipid droplets merged with each other inside the cell by a process that involved a protein known as "SNAP23". This protein has another, independent, function - that of passing the insulin signal onwards into the cell.

"It appears that the SNAP23 is being 'stolen' from the insulin signalling process when the cell starts to pack fat, and this causes the defect that subsequently leads to diabetes. If we can find out more about how this works in detail, we may be able to influence the process and protect patients from developing diabetes", says Pontus Boström, PhD student at the Sahlgrenska Academy.

Further research will be necessary before the results can be tested in patients.

The results will be published in the next issue of the journal Nature Cell Biology.

Journal: Nature Cell Biology
Article title: SNARE proteins mediate fusion between cytosolic lipid droplets with implications for insulin sensitivity

Authors: Pontus Boström, Linda Andersson, Mikale Rutberg, Jeanna Perman, Ulf Lidberg, Bengt R. Johansson, Julia Fernandez-Rodriguez, Tommy Nilsson, Jan Borén and Sven-Olof Olofsson.

For more information, contact: Professor Sven Olof Olofsson, telephone: +46 31 342 1956, e-mail: sven-olof.olofsson@wlab.gu.se Dr. Pontus Boström, telephone: +46 31 342 2947, e-mail: pontus.bostrom@wlab.gu.se

Elin Lindström Claessen | idw
Further information:
http://www.vr.se
http://www.nature.com/ncb/journal/vaop/ncurrent/full/ncb1648.html

Further reports about: Diabetes HDL-cholesterol Insulin Protein droplets

More articles from Life Sciences:

nachricht Toward a 'smart' patch that automatically delivers insulin when needed
18.01.2017 | American Chemical Society

nachricht 127 at one blow...
18.01.2017 | Stiftung Zoologisches Forschungsmuseum Alexander Koenig, Leibniz-Institut für Biodiversität der Tiere

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

A big nano boost for solar cells

18.01.2017 | Power and Electrical Engineering

Glass's off-kilter harmonies

18.01.2017 | Materials Sciences

Toward a 'smart' patch that automatically delivers insulin when needed

18.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>