In a world first, Leeds researchers Professor Simon Phillips, Dr Stephen Carr and Dr Jonathan Hadden, together with Professor David Lilley at Dundee, have mapped the 3 dimensional structure of an enzyme responsible for splitting DNA strands – a process at the heart of human individuality.
The discovery of the T7 endonuclease 1 enzyme’s structure was made by using x-ray crystallography techniques. The enzyme is derived from a bacteriophage – a naturally occurring virus-like agent that attacks bacteria – but the molecular processes are expected to be similar in other organisms, including humans.
“Whilst the enzyme was known to play a central role, its physical structure, which is crucial to understanding the splitting process, has never been seen before. We’ve now got a 3D picture of it at work, and seen it at the point at which it is about to cut through the DNA strands. This is a major breakthrough in investigating the fundamental mechanisms at work behind the formation of a person’s DNA and how viruses replicate their DNA in the body,” says Professor Phillips.
In humans, this process starts at conception when maternal and paternal DNA strands join together at random points in their sequence(1). Enzymes such as T7 endonuclease 1 are then responsible for severing the strands at this junction, thus creating a third, unique DNA sequence for the offspring.
However, Professor Phillips says it will be some time before this process can be observed in humans. “It’s too important a discovery to rush. Our next step is to examine the process in a more complex system than bacteriophage, such as yeast,” he says.
The work is the result of a long collaboration between the research groups at Leeds and Dundee and has been funded by the Wellcome Trust and the Biotechnology and Biological Sciences Research Council (BBSRC) Cancer Research UK.
Clare Elsley | alfa
Cancer diagnosis: no more needles?
25.05.2018 | Christian-Albrechts-Universität zu Kiel
Less is more? Gene switch for healthy aging found
25.05.2018 | Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut e.V. (FLI)
The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.
Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...
A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.
The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
25.05.2018 | Event News
02.05.2018 | Event News
13.04.2018 | Event News
25.05.2018 | Event News
25.05.2018 | Machine Engineering
25.05.2018 | Life Sciences