Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Vienna University of Technology is working on a new doping detection system

16.10.2007
One of the most common substances used for doping is EPO (erythropoietin), which is difficult to detect. In an era when there are increasing numbers of 'copies' of biotechnologically produced medications (biosimilars), it is also becoming more and more difficult to detect the difference between the body's own EPO and that made biosynthetically.

Chemists at Vienna University of Technology (TU) working jointly with ARC Seibersdorf, are developing a new analytical method, based on MALDI mass spectrometry, to track down the perpetrators of doping.

"With the aid of MALDI mass spectrometry, a method that is used for non-destructive desorption/ionisation of large molecules, especially biopolymers, we compare the deceptively similar 'humanised' form of EPO with the body's own substance. The two samples differ in the structure of the amino acid chains and/or in that of the associated sugar chains. Depending on the structure of these sugar chains and where they bind to, we can recognise whether this is a natural or biosynthetic EPO", explains Professor Günter Allmaier of the Institute of Chemical Technologies and Analytics at Vienna University of Technology.

Previous methods, for example isoelectric focusing, exhibit several weaknesses. First, it takes between two and three days to obtain the test results. Furthermore, the method is regarded as difficult to automate, and is based on antibodies which can detect EPO in urine but sometimes are too non-specific and do not distinguish the structure sufficiently precisely. Allmaier and his co-workers are concentrating now on a search for suitable analytical strategies that can detect recombinant EPO directly in urine. Lab-on-chip technology is to be combined with laser-based time-of-flight mass spectrometry. Following the testing phase, Allmaier estimates that the method may reach the patentable stage around 2009 and provide a valuable support in the fight against doping. Allmaier: "The most essential point in our strategy is that we are developing a method with which the EPO molecule itself is detected. All the other methods used so far have been indirect."

... more about:
»Allmaier »Doping »EPO »method

EPO preparations increase the production of red blood cells, which in turn transport more oxygen in the blood. As a result, the organism's performance improves. That is why EPO has been misused for doping as far back as the late 1980s, mainly in endurance sports such as cycling. Recently, Günter Allmaier received the John Beynon Prize Award 2007 for the most innovative publication in the journal Rapid Communications in Mass Spectrometry for the period 2005 to 2006 (http://www3.interscience.wiley.com/cgi-bin/fulltext/114298803/PDFSTART). This work was also the starting point for intensive cooperation with Dr. Reichel of ARC Seibersdorf's doping control laboratory.

Enquiries to:
Prof. Günter Allmaier
Vienna University of Technology
Institute of Chemical Technologies and Analytics
9/164 Getreidemarkt, 1060 Vienna, Austria
T +43/1/58801 - 15160
F +43/1/58801 - 15199
E guenter.allmaier@tuwien.ac.at
Sent by:
Mag. Daniela Ausserhuber
Vienna University of Technology - PR and Communication
13/E011 Karlsplatz, A-1040 Vienna, Austria
T +43-1-58801-41027
F +43-1-58801-41093
E daniela.ausserhuber@tuwien.ac.at

Werner Sommer | idw
Further information:
http://www.tuwien.ac.at/pr
http://www3.interscience.wiley.com/cgi-bin/fulltext/114298803/PDFSTART

Further reports about: Allmaier Doping EPO method

More articles from Life Sciences:

nachricht Newly designed molecule binds nitrogen
23.02.2018 | Julius-Maximilians-Universität Würzburg

nachricht Atomic Design by Water
23.02.2018 | Max-Planck-Institut für Eisenforschung GmbH

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Attoseconds break into atomic interior

A newly developed laser technology has enabled physicists in the Laboratory for Attosecond Physics (jointly run by LMU Munich and the Max Planck Institute of Quantum Optics) to generate attosecond bursts of high-energy photons of unprecedented intensity. This has made it possible to observe the interaction of multiple photons in a single such pulse with electrons in the inner orbital shell of an atom.

In order to observe the ultrafast electron motion in the inner shells of atoms with short light pulses, the pulses must not only be ultrashort, but very...

Im Focus: Good vibrations feel the force

A group of researchers led by Andrea Cavalleri at the Max Planck Institute for Structure and Dynamics of Matter (MPSD) in Hamburg has demonstrated a new method enabling precise measurements of the interatomic forces that hold crystalline solids together. The paper Probing the Interatomic Potential of Solids by Strong-Field Nonlinear Phononics, published online in Nature, explains how a terahertz-frequency laser pulse can drive very large deformations of the crystal.

By measuring the highly unusual atomic trajectories under extreme electromagnetic transients, the MPSD group could reconstruct how rigid the atomic bonds are...

Im Focus: Developing reliable quantum computers

International research team makes important step on the path to solving certification problems

Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...

Im Focus: In best circles: First integrated circuit from self-assembled polymer

For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.

In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Basque researchers turn light upside down

23.02.2018 | Physics and Astronomy

Finnish research group discovers a new immune system regulator

23.02.2018 | Health and Medicine

Attoseconds break into atomic interior

23.02.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>