Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Animal food allergens unmasked

15.10.2007
The relatedness of an animal food protein to a human protein determines whether it can cause allergy, according to new research by scientists from the Institute of Food Research in Norwich and the Medical University of Vienna.

In theory all proteins have the potential to become allergens, but the study found that in practice the ability of animal food proteins to act as allergens depends on their evolutionary distance from a human equivalent.

“This explains why people who are allergic to cow’s milk can often tolerate mare’s milk but not goat’s milk”, said Dr Clare Mills of the Institute of Food Research. “Proteins in horse milk are up to 66% identical to human milk proteins, while known allergens from cows and goats are all less than 53% identical to corresponding human proteins.

“Overall we found that only an animal food protein that is less than 54% identical to a human equivalent could become allergenic”.

... more about:
»Allergy »Food »identical »tropomyosin

Cow’s milk and hen’s eggs are common causes of allergy in infants, while the most common animal food allergens in adults are fish and seafood.

For the first time the researchers found that the majority of animal food allergens could be classified into one of three protein families. Tropomyosins, proteins found in muscle tissue, are the most important family.

“Tropomyosins in mammals, fish and birds are at least 90% identical to at least one human tropomyosin and none have been reported to be allergenic. In contrast, the allergenic tropomyosins are all from invertebrates such as insects, crustaceans and nematodes and at most are only 55% identical to the closest human homologue”, said Dr Heimo Breiteneder of the Medical University of Vienna.

EF-hand proteins form the second largest animal food allergen family. Those in birds and mammals are not allergenic, while those in frogs and fish can cause allergy. The third animal food allergen family, caseins, are all mammalian proteins from milk. The researchers analysed milk from rabbits, rats and camels as well as sheep, goats, cows and horses.

In previous analyses of plant food allergens published in 2005, the scientists found that most belong to a highly restricted number of protein superfamilies. The research will make it easier to identify new allergens and help explain how they trigger an immune response.

“Animal food proteins lie at the limits of the capability of the human immune system to discriminate between foreign and self proteins”, said Dr Mills. “Immune responses to some animal food allergens such as the invertebrate tropomyosins, run close to becoming a form of autoimmune response and this needs to be considered when developing allergy therapies”.

Zoe Dunford | alfa
Further information:
http://www.bbsrc.ac.uk

Further reports about: Allergy Food identical tropomyosin

More articles from Life Sciences:

nachricht New application for acoustics helps estimate marine life populations
16.01.2018 | University of California - San Diego

nachricht Unexpected environmental source of methane discovered
16.01.2018 | University of Washington Health Sciences/UW Medicine

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

Im Focus: A thermometer for the oceans

Measurement of noble gases in Antarctic ice cores

The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

White graphene makes ceramics multifunctional

16.01.2018 | Materials Sciences

Breaking bad metals with neutrons

16.01.2018 | Materials Sciences

ISFH-CalTeC is “designated test centre” for the confirmation of solar cell world records

16.01.2018 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>